-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
Open accessAbstract
Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with Abeta burden in non-demented persons and in AD patients is unclear. We examined this relationship using 11C-PIB-PET as a quantitative marker of Abeta burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a 11C-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to Abeta burden. Ninety-seven percent of AD, 61% of MCI and 22% of HA cases had increased cortical PIB binding, indicating the presence of Abeta plaques. There was a strong relationship between impaired episodic memory performance and PIB binding, both in MCI and HA. This relationship was weaker in AD and less robust for non-memory cognitive domains. Abeta deposition in the asymptomatic elderly is associated with episodic memory impairment. This finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical PIB binding are on the path to Alzheimer's disease. The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Abeta deposition are warranted.
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Studies of non-demented elderly cohorts overall report approximately 20-40% are PIB-positive.
“Studies of non-demented elderly cohorts overall report approximately 20–40% are PIB-positive [67, 68, 71–78].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [72]
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- Authors
- Pike, K. E., Savage, G., Villemagne, V. L., Ng, S., Moss, S. A., Maruff, P., Mathis, C. A., Klunk, W. E., Masters, C. L., & Rowe, C. C.
- Affiliations
- Mental Health Research Institute (AU)
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-05
- Volume
- 130
- Issue
- 11
- Pages
- 2837-2844
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2166416515
- Cited by
- 789
- References
- 58
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 21 · 2021: 27 · 2020: 29 · 2019: 32 · 2018: 37 · 2017: 38 · 2016: 39 · 2015: 37 · 2014: 57 · 2013: 75 · 2012: 75
- FWCI
- 37.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Brain (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Australian Government
- Monash University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- preclinical Alzheimer's disease, amyloid-beta deposition, 11C-PiB PET, episodic memory impairment, mild cognitive impairment, healthy aging, amyloid plaques
- MeSH terms
- Aged, Alzheimer Disease, Aniline Compounds, Apolipoproteins E, Carbon Radioisotopes, Cerebellar Cortex, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Mutation, Neuropsychological Tests, Thiazoles, Biomarkers, Chi-Square Distribution, Case-Control Studies, Amyloid beta-Peptides, Positron-Emission Tomography, Benzothiazoles
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