TAR DNA‐binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features
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OBJECTIVE: The aim of this study was to determine whether the frequency of TAR DNA-binding protein 43 (TDP-43) deposition in Alzheimer's disease (AD) differs across pathologically defined AD subtypes (hippocampal sparing [HpSp]; typical and limbic) and further examine the relationship between TDP-43, pathological subtype, and clinical features in AD. METHODS: We identified all cases with pathologically confirmed AD (NIA-Reagan intermediate-high probability, Braak stage IV-VI) independent of cognitive status (n = 188). Neurofibrillary tangle counts were performed using thioflavin-S microscopy in hippocampus and three neocortical regions, and all cases were subtyped: HpSp AD pathology (n = 19); typical AD pathology (n = 136); and limbic AD pathology (n = 33). TDP-43 immunoreactivity was performed in multiple brain regions to assess for the presence of TDP-43 and TDP-43 stage. All cases were clinically subclassified at presentation as amnestic AD dementia versus atypical AD dementia. Statistical analysis was performed using linear and penalized logistic regression to assess associations with pathological subtype, and the effects of TDP-43, accounting for possible interactions between pathological subtype and TDP-43. RESULTS: TDP-43 deposition was frequent in typical (59%) and limbic AD pathologies (67%), but not HpSp AD pathology (21%; p = 0.003). The observed associations of TDP-43 with greater memory loss, naming and functional decline, and smaller hippocampal volumes, closest to death, did not differ across AD pathological subtype. Clinical presentation was associated with pathological subtype (p = 0.01), but not TDP-43 (p = 0.69). INTERPRETATION: Although the frequency of TDP-43 deposition in AD varies by pathological subtype, the observed effects of TDP-43 on clinical/magnetic resonance imaging features are consistent across pathological subtypes. Clinical presentation in AD is driven by pathological subtype, not by TDP-43.
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TDP-43 deposits are more common in typical AD and limbic-predominant AD than hippocampal-sparing AD.
“TDP-43 deposits are more common in typical AD and limbic-predominant AD than hippocampal-sparing AD [134].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [134]
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Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Wechsler Adult Intelligence Scale-III
Ryan, J. J., & Lopez, S. J. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1185-4_2 · Cited by 3,680 · see citing works
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
Approximate is Better than “Exact” for Interval Estimation of Binomial Proportions
Agresti, A., & Coull, B. A. (1998) · The American Statistician · doi:10.1080/00031305.1998.10480550 · Cited by 3,223 · see citing works
Reynolds, C. R., & Powel, J. (1988) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/3.4.397 · Cited by 2,115 · see citing works
Approximate Is Better than "Exact" for Interval Estimation of Binomial Proportions
Agresti, A., & Coull, B. A. (1998) · The American Statistician · doi:10.2307/2685469 · Cited by 980 · see citing works
Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70156-9 · Cited by 972 · see citing works
Self-citationJack, C. R., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., Knopman, D. S., Boeve, B. F., Klunk, W. E., Mathis, C. A., et al. (2008) · Brain · doi:10.1093/brain/awm336 · Cited by 958 · see citing works
Self-citationTDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
Amador‐Ortiz, C., Lin, W., Ahmed, Z., Personett, D., Davies, P., Duara, R., Graff‐Radford, N. R., Hutton, M. L., & Dickson, D. W. (2007) · Annals of Neurology · doi:10.1002/ana.21154 · Cited by 916 · see citing works
Self-citationAberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
Zhang, Y., Xu, Y.-F., Cook, C. N., Gendron, T. F., Roettges, P. S., Link, C. D., Lin, W.-L., Tong, J., Castanedes‐Casey, M., Ash, P. E. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900688106 · Cited by 604 · see citing works
Self-citationTDP-43 is a key player in the clinical features associated with Alzheimer’s disease
Josephs, K. A., Whitwell, J. L., Weigand, S. D., Murray, M. E., Tosakulwong, N., Liesinger, A. M., Petrucelli, L., Senjem, M. L., Knopman, D. S., Boeve, B. F., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1269-z · Cited by 481 · see citing works
Self-citationNeuroimaging correlates of pathologically-defined atypical Alzheimer’s disease
Whitwell, J. L., Dickson, D., Murray, M., Weigand, S., Tosakulwong, N., Senjem, M., Knopman, D., Boeve, B., Parisi, J., Petersen, R., et al. (2012) · Lancet Neurology · doi:10.1016/s1474-4422(12)70200-4 · Cited by 419 · see citing works
Self-citationUryu, K., Nakashima-Yasuda, H., Forman, M. S., Kwong, L. K., Clark, C. M., Grossman, M., Miller, B. L., Kretzschmar, H. A., Lee, V. M.-Y., Trojanowski, J. Q., et al. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31817713b5 · Cited by 382 · see citing works
Staging TDP-43 pathology in Alzheimer’s disease
Josephs, K. A., Murray, M. E., Whitwell, J. L., Parisi, J. E., Petrucelli, L., Jack, C. R., Petersen, R. C., & Dickson, D. W. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1211-9 · Cited by 366 · see citing works
Self-citationWhitwell, J. L., Crum, W. R., Watt, H., & Fox, N. C. (2001) · PubMed Central · Cited by 357 · see citing works
Self-citationPhosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies
Arai, T., Mackenzie, I. R. A., Hasegawa, M., Nonoka, T., Niizato, K., Tsuchiya, K., Iritani, S., Onaya, M., & Akiyama, H. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0480-1 · Cited by 345 · see citing works
Hippocampal sclerosis and <scp>TDP</scp> ‐43 pathology in aging and <scp>A</scp> lzheimer disease
Nag, S., Yu, L., Capuano, A. W., Wilson, R. S., Leurgans, S. E., Bennett, D. A., & Schneider, J. A. (2015) · Annals of Neurology · doi:10.1002/ana.24388 · Cited by 305 · see citing works
Hippocampal sclerosis in advanced age: clinical and pathological features
Nelson, P. T., Schmitt, F. A., Lin, Y., Abner, E. L., Jicha, G. A., Patel, E., Thomason, P. C., Neltner, J. H., Smith, C. D., Santacruz, K. S., et al. (2011) · Brain · doi:10.1093/brain/awr053 · Cited by 279 · see citing works
Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype
Josephs, K. A., Whitwell, J. L., Knopman, D. S., Hu, W. T., Stroh, D. A., Baker, M., Rademakers, R., Boeve, B. F., Parisi, J. E., Smith, G. E., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000304041.09418.b1 · Cited by 254 · see citing works
Self-citationTDP-43 Pathology, Cognitive Decline, and Dementia in Old Age
Wilson, R. S., Yu, L., Trojanowski, J. Q., Chen, E., Boyle, P. A., Bennett, D. A., & Schneider, J. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3961 · Cited by 248 · see citing works
Davidson, Y. S., Raby, S., Foulds, P. G., Robinson, A., Thompson, J. C., Sikkink, S. K., Yusuf, I. H., Amin, H., DuPlessis, D., Troakes, C., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0879-y · Cited by 155 · see citing works
Progressive aphasia secondary to Alzheimer disease vs FTLD pathology
Josephs, K. A., Whitwell, J. L., Duffy, J. R., VanVoorst, W. A., Strand, E. A., Hu, W. T., Boeve, B. F., Graff‐Radford, N. R., Parisi, J. E., Knopman, D. S., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000287073.12737.35 · Cited by 153 · see citing works
Self-citationDifferential clinicopathologic and Genetic features of late-onset amnestic dementias
Murray, M., Cannon, A., Graff-Radford, N., Liesinger, A. M., Rutherford, N., Ross, O., Duara, R., Carrasquillo, M., Rademakers, R., & Dickson, D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1302-2 · Cited by 150 · see citing works
Self-citationTemporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease
Hu, W. T., Josephs, K. A., Knopman, D. S., Boeve, B. F., Dickson, D. W., Petersen, R. C., & Parisi, J. E. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0400-4 · Cited by 134 · see citing works
Self-citationTemporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis
Whitwell, J., Clifford, R., Przybelski, S., Parisi, J., Senjem, M., Boeve, B., Knopman, D., Petersen, R., Dickson, D., & Josephs, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.012 · Cited by 131 · see citing works
Self-citationKadokura, A., Yamazaki, T., Lemere, C. A., Takatama, M., & Okamoto, K. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01017.x · Cited by 104 · see citing works
Bayesian regression in SAS software
Sullivan, S. G., & Greenland, S. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys213 · Cited by 87 · see citing works
Bigio, E. H., Mishra, M., Hatanpaa, K. J., White, C. L., Johnson, N., RADEMAKER, A. W., Weitner, B. B., Deng, H., Dubner, S., Weıntraub, S., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0681-2 · Cited by 78 · see citing works
TDP-43 in Alzheimer’s disease is not associated with clinical FTLD or Parkinsonism
Jung, Y., Dickson, D. W., Murray, M. E., Whitwell, J. L., Knopman, D. S., Boeve, B. F., Jack, C. R., Parisi, J. E., Petersen, R. C., & Josephs, K. A. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7352-5 · Cited by 22 · see citing works
Self-citationUnlocking the mysteries of TDP-43
Josephs, K. A., & Nelson, P. T. (2015) · Neurology · doi:10.1212/wnl.0000000000001322 · Cited by 11 · see citing works
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The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“TDP-43 deposits are more common in typical AD and limbic-predominant AD than hippocampal-sparing AD [134].”
BackgroundSelf-citationLimbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., et al. (2019) · Brain · doi:10.1093/brain/awz099 · Cited by 1,547 · see citing works
Self-citationNew insights into atypical Alzheimer's disease in the era of biomarkers
Graff-Radford, J., Yong, K. X. X., Apostolova, L. G., Bouwman, F. H., Carrillo, M., Dickerson, B. C., Rabinovici, G. D., Schott, J. M., Jones, D. T., & Murray, M. E. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30440-3 · Cited by 706 · see citing works
Self-citationBiological subtypes of Alzheimer disease
Ferreira, D., Nordberg, A. K., & Westman, E. (2020) · Neurology · doi:10.1212/wnl.0000000000009058 · Cited by 427 · see citing works
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Trejo‐Lopez, J. A., Yachnis, A. T., & Prokop, S. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01146-y · Cited by 398 · see citing works
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Josephs, K. A., Murray, M. E., Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Petrucelli, L., Liesinger, A. M., Petersen, R. C., Parisi, J. E., & Dickson, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1537-1 · Cited by 366 · see citing works
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Meneses, A. D., Koga, S., O’Leary, J., Dickson, D. W., Bu, G., & Zhao, N. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00503-x · Cited by 360 · see citing works
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Li, Z., Shue, F., Zhao, N., Shinohara, M., & Bu, G. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00413-4 · Cited by 306 · see citing works
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Prudencio, M., Humphrey, J., Pickles, S., Brown, A.-L., Hill, S. E., Kachergus, J. M., Shi, J., Heckman, M. G., Spiegel, M. R., Cook, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci139741 · Cited by 231 · see citing works
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McAleese, K. E., Walker, L., Erskine, D., Thomas, A. J., McKeith, I. G., & Attems, J. (2016) · Brain Pathology · doi:10.1111/bpa.12424 · Cited by 264 · see citing works
Josephs, K. A., Dickson, D. W., Tosakulwong, N., Weigand, S. D., Murray, M. E., Petrucelli, L., Liesinger, A. M., Senjem, M. L., Spychalla, A. J., Knopman, D. S., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30284-3 · Cited by 252 · see citing works
Self-citationLATE-NC staging in routine neuropathologic diagnosis: an update
Nelson, P. T., Lee, E. B., Cykowski, M. D., Alafuzoff, I. I., Arfanakis, K., Attems, J., Brayne, C., Corrada, M. M., Dugger, B. N., Flanagan, M. E., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02524-2 · Cited by 175 · see citing works
Self-citationJosephs, K. A., Murray, M. E., Tosakulwong, N., Whitwell, J. L., Knopman, D. S., Machulda, M. M., Weigand, S. D., Boeve, B. F., Kantarci, K., Petrucelli, L., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1681-2 · Cited by 166 · see citing works
Self-citationDisentangling Heterogeneity in Alzheimer’s Disease and Related Dementias Using Data-Driven Methods
Habes, M., Grothe, M. J., Tunc, B., McMillan, C., Wolk, D. A., & Davatzikos, C. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.016 · Cited by 167 · see citing works
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Jellinger, K. A. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02449-2 · Cited by 150 · see citing works
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Woo, J. A., Liu, T., Trotter, C., Fang, C. C., Narvaez, E. D., LePochat, P., Maslar, D., Bukhari, A., Zhao, X., Deonarine, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15558 · Cited by 135 · see citing works
Ginsenoside Rg1 in neurological diseases: From bench to bedside
Yang, S., Wang, J.-J., Cheng, P., Chen, L.-X., Hu, J., & Zhu, G. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01022-1 · Cited by 122 · see citing works
Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Perkerson, R. B., Matchett, B. J., Jack, C. R., Knopman, D. S., Petersen, R. C., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1951-7 · Cited by 107 · see citing works
Self-citationTomé, S. O., Vandenberghe, R. R., Ospitalieri, S., Schoor, E. V., Tousseyn, T., Otto, M., Arnim, C. A. F. V., & Thal, D. R. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00934-5 · Cited by 106 · see citing works
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Smith, V. D., Bachstetter, A. D., Ighodaro, E. T., Roberts, K. N., Abner, E. L., Fardo, D. W., & Nelson, P. T. (2017) · Brain Pathology · doi:10.1111/bpa.12505 · Cited by 104 · see citing works
Sun, M., Bell, W., LaClair, K. D., Ling, J. P., Han, H., Kageyama, Y., Pletniková, O., Troncoso, J. C., Wong, P. C., & Chen, L. L. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1701-2 · Cited by 101 · see citing works
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Wennberg, A. M. V., Tosakulwong, N., Lesnick, T. G., Murray, M. E., Whitwell, J. L., Liesinger, A. M., Petrucelli, L., Boeve, B. F., Parisi, J. E., Knopman, D. S., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.3139 · Cited by 96 · see citing works
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Quadros, A. R. A. D. A., Li, Z., Wang, X., Ndayambaje, I. S., Aryal, S., Ramesh, N., Nolan, M., Jayakumar, R., Han, Y., Stillman, H., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02655-0 · Cited by 74 · see citing works
Self-citationJosephs, K. A., Martin, P. R., Weigand, S. D., Tosakulwong, N., Buciuc, M., Murray, M. E., Petrucelli, L., Senjem, M. L., Spychalla, A. J., Knopman, D. S., et al. (2020) · Brain · doi:10.1093/brain/awaa299 · Cited by 77 · see citing works
Self-citationBejanin, A., Murray, M. E., Martin, P. R., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., et al. (2019) · Brain · doi:10.1093/brain/awz277 · Cited by 76 · see citing works
Self-citationGrothe, M. J., Moscoso, A., Silva‐Rodríguez, J., Lange, C., Nho, K. T., Saykin, A. J., Nelson, P. T., Schöll, M., Buchert, R., Teipel, S. J., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12763 · Cited by 70 · see citing works
Genin, E. C., Bannwarth, S., Lespinasse, F., Ortega-Vila, B., Fragaki, K., Itoh, K., Villa, E., Lacas‐Gervais, S., Jokela, M. E., Auranen, M., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.027 · Cited by 72 · see citing works
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Buciuc, M., Botha, H., Murray, M. E., Schwarz, C. G., Senjem, M. L., Jones, D. T., Knopman, D. S., Boeve, B. F., Petersen, R. C., Jack, C. R., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009722 · Cited by 70 · see citing works
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Jellinger, K. (2021) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000508625 · Cited by 64 · see citing works
Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease
Kang, D. E., & Woo, J. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190585 · Cited by 67 · see citing works
Mormino, E. C., Papp, K. V., Rentz, D. M., Schultz, A. P., LaPoint, M. R., Amariglio, R. E., Hanseeuw, B. J., Marshall, G. A., Hedden, T., Johnson, K. A., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2237 · Cited by 65 · see citing works
King, A., Bódi, I., & Troakes, C. (2020) · Brain Sciences · doi:10.3390/brainsci10080479 · Cited by 63 · see citing works
Nag, S., & Schneider, J. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00846-7 · Cited by 65 · see citing works
Uemura, M. T., Robinson, J. L., Cousins, K. A. Q., Tropea, T. F., Kargilis, D., McBride, J. D., Suh, E. R., Xie, S. X., Xu, Y., Porta, S., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02383-3 · Cited by 59 · see citing works
Gelon, P. A., Dutchak, P. A., & Sephton, C. F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1000183 · Cited by 59 · see citing works
Koga, S., Lin, W. ‐., Walton, R. L., Ross, O. A., & Dickson, D. W. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12485 · Cited by 58 · see citing works
Self-citationTDP-43 interacts with pathological τ protein in Alzheimer’s disease
Tomé, S. O., Gomes, L. A., Li, X., Vandenberghe, R. R., Tousseyn, T., & Thal, D. R. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02295-2 · Cited by 56 · see citing works
Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease
Teipel, S. J., Fritz, H.-C., Grothe, M. J., & Initiative, A. D. N. (2020) · Neurology · doi:10.1212/wnl.0000000000010192 · Cited by 56 · see citing works
Thomas, D. X., Bajaj, S., McRae‐McKee, K., Hadjichrysanthou, C., Anderson, R. M., & Collinge, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-71305-2 · Cited by 52 · see citing works
Moda, F., Ciullini, A., Dellarole, I. L., Lombardo, A., Campanella, N., Bufano, G., Cazzaniga, F. A., & Giaccone, G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2810255 · Cited by 48 · see citing works
RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights
Rummens, J., & Cruz, S. D. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00851-y · Cited by 52 · see citing works
White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition
Raghavan, S., Przybelski, S. A., Reid, R. I., Lesnick, T. G., Ramanan, V. K., Botha, H., Matchett, B. J., Murray, M. E., Reichard, R. R., Knopman, D. S., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01319-6 · Cited by 50 · see citing works
Self-citationTDP-43 drives synaptic and cognitive deterioration following traumatic brain injury
Gao, F., Hu, M., Zhang, J., Hashem, J., & Chen, C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02449-w · Cited by 48 · see citing works
Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease
Collij, L. E., Mastenbroek, S. E., Mattsson, N., Strandberg, O. T., Smith, R. A., Janelidze, S., Palmqvist, S., Ossenkoppele, R., & Hansson, O. (2024) · Nature Communications · doi:10.1038/s41467-024-52299-1 · Cited by 46 · see citing works
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
Latimer, C., Stair, J. G., Hincks, J. C., Currey, H. N., Bird, T., Keene, C., Kraemer, B., & Liachko, N. F. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049323 · Cited by 37 · see citing works
Altered thyroid hormone profile in patients with Alzheimer’s disease
Quinlan, P. S., Horváth, A., Eckerström, C., Wallin, A., & Svensson, J. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104844 · Cited by 43 · see citing works
Neuropathology of the Alzheimer's continuum: an update
Jellinger, K. A. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3050 · Cited by 45 · see citing works
TDP-43 Is Elevated in Plasma Neuronal-Derived Exosomes of Patients With Alzheimer’s Disease
Zhang, N., Gu, D., Meng, M., & Gordon, M. L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00166 · Cited by 43 · see citing works
Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers
Thal, D. R., Poesen, K., Vandenberghe, R. R., & Meyer, S. D. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00819-y · Cited by 47 · see citing works
In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies
Hanko, V., Apple, A. C., Alpert, K. I., Warren, K., Schneider, J. A., Arfanakis, K., Bennett, D. A., & Wang, L. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.013 · Cited by 41 · see citing works
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
Koper, M. J., Tomé, S. O., Gawor, K., Belet, A., Schoor, E. V., Schaeverbeke, J. M., Vandenberghe, R. R., Vandenbulcke, M., Ghebremedhin, E., Otto, M., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01432-6 · Cited by 41 · see citing works
Mitochondrial fragmentation and network architecture in degenerative diseases
Shah, S. I., Paine, J. G., Perez, C., & Ullah, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223014 · Cited by 39 · see citing works
Gao, J., Wang, L., Gao, C., Arakawa, H., Perry, G. L., & Wang, X. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165580 · Cited by 38 · see citing works
Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype
Buciuc, M., Whitwell, J. L., Kasanuki, K., Graff‐Radford, J., Machulda, M. M., Duffy, J. R., Strand, E. A., Lowe, V. J., Graff‐Radford, N. R., Rush, B. K., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25979 · Cited by 37 · see citing works
Self-citationCryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research
Todd, T. W., Islam, N. N., Cook, C. N., Caulfield, T. R., & Petrucelli, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.012 · Cited by 36 · see citing works
Self-citationLanguage and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes
Resende, E. D. P. F., Nolan, A., Petersen, C., Ehrenberg, A. J., Spina, S., Allen, I. E., Rosen, H. J., Kramer, J. H., Miller, B. L., Seeley, W. W., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000008937 · Cited by 35 · see citing works
Role of Cofilin in Alzheimer’s Disease
Wang, Q., Yuan, W., Yang, X., Wang, Y., Li, Y., & Qiao, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584898 · Cited by 35 · see citing works
Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy
Kim, D., Kim, H.-S., Choi, S., Kim, B. C., Lee, M. C., Lee, K., & Lee, J.-H. (2019) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2019.03.14 · Cited by 34 · see citing works
Cykowski, M. D., Powell, S. Z., Schulz, P. E., Takei, H., Rivera, A. L., Jackson, R. E., Roman, G., Jicha, G. A., & Nelson, P. T. (2017) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2016-0469-sa · Cited by 33 · see citing works
Dysautonomia in Alzheimer's Disease
Tulbă, D., Cozma, L., Popescu, B. O., & Davidescu, E. I. (2020) · Medicina · doi:10.3390/medicina56070337 · Cited by 32 · see citing works
Neuropathologic Features of Antemortem Atrophy-Based Subtypes of Alzheimer Disease
Mohanty, R., Ferreira, D., Frerich, S., Muehlboeck, J., Grothe, M. J., Westman, E., & Initiative, A. D. N. (2022) · Neurology · doi:10.1212/wnl.0000000000200573 · Cited by 32 · see citing works
Fazeli, E., Child, D. D., Bucks, S. A., Stovarsky, M., Edwards, G., Rose, S. E., Yu, C., Latimer, C. S., Kitago, Y., Bird, T. D., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02670-1 · Cited by 31 · see citing works
Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Knopman, D. S., Petersen, R. C., Jack, C. R., Whitwell, J. L., & Dickson, D. W. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.03.003 · Cited by 31 · see citing works
Self-citationLiu, K. Y., Reeves, S., McAleese, K. E., Attems, J., Francis, P. T., Thomas, A. J., & Howard, R. J. (2020) · Brain · doi:10.1093/brain/awaa315 · Cited by 31 · see citing works
Ferreira, D., Mohanty, R., Murray, M. E., Nordberg, A. K., Kantarci, K., & Westman, E. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01471-z · Cited by 30 · see citing works
Self-citationClinical relevance of brain atrophy subtypes categorization in memory clinics
Planche, V., Bouteloup, V., Mangin, J., Dubois, B., Delrieu, J., Pasquier, F., Blanc, F., Paquet, C., Hanon, O., Gabelle, A., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12231 · Cited by 32 · see citing works
Primary Progressive Aphasia and the Left Hemisphere Language Network
Mesulam, M. M. (2016) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2016.15.4.93 · Cited by 29 · see citing works
Weng, Y., Chang, Y., & Chern, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043443 · Cited by 29 · see citing works
Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies
Golde, T. E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13583 · Cited by 28 · see citing works
TDP-43 and Alzheimer’s Disease Pathologic Subtype in Non-Amnestic Alzheimer’s Disease Dementia
Sahoo, A., Bejanin, A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Senjem, M. L., Machulda, M. M., Parisi, J. E., Boeve, B. F., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180169 · Cited by 28 · see citing works
Self-citationJiang, L., Zhang, X.-L., & Hu, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212380 · Cited by 24 · see citing works
MRI and flortaucipir relationships in Alzheimer's phenotypes are heterogeneous
Josephs, K. A., Tosakulwong, N., Graff‐Radford, J., Weigand, S. D., Buciuc, M., Machulda, M. M., Jones, D. T., Schwarz, C. G., Senjem, M. L., Ertekin‐Taner, N., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51038 · Cited by 22 · see citing works
Self-citationWoodworth, D. C., Nguyen, K. M., Sordo, L., Scambray, K. A., Head, E., Kawas, C. H., Corrada, M. M., Nelson, P. T., & Sajjadi, S. A. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02728-8 · Cited by 22 · see citing works
Kotarba, S., Kozłowska, M., Scios, M., Saramowicz, K., Barczuk, J., Granek, Z., Siwecka, N., Wiese, W., Golberg, M., Galita, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910797 · Cited by 21 · see citing works
Neurodegenerative Diseases and Ageing
Walker, L., McAleese, K. E., Erskine, D., & Attems, J. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_4 · Cited by 21 · see citing works
Kobayashi, G., Hirata, K., Ono, M., Kasuga, K., & Takado, Y. (2026) · Frontiers in Dementia · doi:10.3389/frdem.2026.1736297 · Cited by 21 · see citing works
Wu, R., Zhou, D., Shen, X., Chen, F., Liu, F., & Gu, J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15450 · Cited by 19 · see citing works
Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations
Pottier, C. P., Mateiu, L. M., Baker, M., DeJesus‐Hernandez, M., Vicente, C. T., Finch, N. A., Tian, S., van Blitterswijk, M., Murray, M. E., Ren, Y., et al. (2021) · Brain · doi:10.1093/brain/awab437 · Cited by 19 · see citing works
Self-citationLATE‐NC in Alzheimer's disease: Molecular aspects and synergies
Tomé, S. O., Gawor, K., & Thal, D. R. (2023) · Brain Pathology · doi:10.1111/bpa.13213 · Cited by 19 · see citing works
Elevation of casein kinase 1ε associated with TDP‐43 and tau pathologies in Alzheimer's disease
Gu, J., Hu, W. H., Tan, X., Qu, S., Chu, D., Gong, C., Iqbal, K., & Liu, F. (2019) · Brain Pathology · doi:10.1111/bpa.12775 · Cited by 18 · see citing works
McAleese, K. E., Walker, L., Erskine, D., Johnson, M. A., Koss, D. J., Thomas, A. J., & Attems, J. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12664 · Cited by 18 · see citing works
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
Dellar, E. R., Nikel, L., Fowler, S. L., Vahsen, B. F., Dafinca, R., Feneberg, E., Talbot, K., Turner, M. R., & Thompson, A. G. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00859-4 · Cited by 17 · see citing works
Shenoy, J., Lends, A., Berbon, M., Abdul-Shukkoor, M. B., Mammeri, N. E., Bertoni, M., Saad, A., Morvan, E., Grélard, A., Lecomte, S., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1148302 · Cited by 16 · see citing works
Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
Murakami, A., Koga, S., Sekiya, H., Oskarsson, B., Boylan, K., Petrucelli, L., Josephs, K. A., & Dickson, D. W. (2022) · Brain Pathology · doi:10.1111/bpa.13100 · Cited by 15 · see citing works
Self-citationTDP‐43 pathology effect on volume and flortaucipir uptake in Alzheimer's disease
Carlos, A. F., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Schwarz, C. G., Knopman, D. S., Boeve, B. F., Petersen, R. C., Nguyen, A. T., Reichard, R. R., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12878 · Cited by 16 · see citing works
Self-citationBuciuc, M., Whitwell, J. L., Baker, M., Rademakers, R., Dickson, D. W., & Josephs, K. A. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12727 · Cited by 16 · see citing works
Self-citationMorderer, D., Wren, M. C., Liu, F., Kouri, N., Maistrenko, A., Khalil, B., Pobitzer, N., Salemi, M., Phinney, B. S., Bu, G., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00817-0 · Cited by 19 · see citing works
Self-citationSimonetti, F., Zhong, W., Hutten, S., Uliana, F., Schifferer, M., Rezaei, A., Ramirez, L. M., Hochmair, J., Sankar, R., Gopalan, A. B., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00590-2 · Cited by 22 · see citing works
Fish Consumption, Brain Mercury, and Neuropathology in Patients With Alzheimer Disease and Dementia
Kröger, E., & Laforce, R. J. (2016) · JAMA · doi:10.1001/jama.2016.0005 · Cited by 15 · see citing works
Atypical clinical variants of Alzheimer’s disease: are they really atypical?
Whitwell, J. L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1352822 · Cited by 14 · see citing works
Self-citationBuciuc, M., Whitwell, J. L., Boeve, B. F., Ferman, T. J., Graff‐Radford, J., Savica, R., Kantarci, K., Fields, J. A., Knopman, D. S., Petersen, R. C., et al. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09718-2 · Cited by 14 · see citing works
Self-citationThe unique neuropathological vulnerability of the human brain to aging
Ferrer, I. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101916 · Cited by 14 · see citing works
Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome
Hosaka, Y., Inoshita, T., Shiba‐Fukushima, K., Cui, C., Arano, T., Imai, Y., & Hattori, N. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.002 · Cited by 13 · see citing works
Lavrova, A., Pham, N. T. T., Vernon, C. J., Carlos, A. F., Petersen, R. C., Dickson, D. W., Lowe, V. J., Jack, C. R., Whitwell, J. L., & Josephs, K. A. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12312-5 · Cited by 12 · see citing works
Self-citationEvaluating the updated LATE‐NC staging criteria using data from NACC
Woodworth, D. C., Nguyen, K. M., Sordo, L., Scambray, K. A., Head, E., Kawas, C. H., Corrada, M. M., Nelson, P. T., & Sajjadi, S. A. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14262 · Cited by 12 · see citing works
- Authors
- Josephs, K. A., Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Murray, M. E., Liesinger, A. M., Petrucelli, L., Senjem, M. L., Ivnik, R. J., Parisi, J. E., Petersen, R. C., & Dickson, D. W.
- Affiliations
- Departments of Neurology (Behavioral Neurology)
- Radiology (Radiology Research)
- Health Science Research (Biostatistics)
- Mayo Clinic (US)
- Neuropsychiatry (Neuropsychology)
- Laboratory Medicine and Pathology (Neuropathology)
- Corresponding author
- Josephs, Keith A.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2015-09-16
- Volume
- 78
- Issue
- 5
- Pages
- 697-709
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC4623932
- OpenAlex
- W1921675910
- Cited by
- 147
- References
- 39
- Citations by year
- 2026: 20 · 2025: 15 · 2024: 20 · 2023: 7 · 2022: 16 · 2021: 10 · 2020: 26 · 2019: 12 · 2018: 5 · 2017: 9 · 2016: 7
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 AG037491 [K.A.J.], R21-AG038736 [J.L.W.], and P50-AG016574 [R.C.P.])
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- TDP-43, Alzheimer's disease, pathological subtypes, hippocampal sparing, typical Alzheimer's disease, neurofibrillary tangles, clinical features, hippocampal volume, memory loss, functional decline
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition, DNA-Binding Proteins, Female, Gene Frequency, Hippocampus, Humans, Limbic System, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Neurofibrillary Tangles, Age of Onset, Disease Progression, Neocortex, TDP-43 Proteinopathies
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