The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Treatment of spasticity with botulinum toxin: A double‐blind study
Abstract
We studied the effect of botulinum‐A toxin on spasticity of the leg adductors in 9 patients who were either chair‐bound or bed‐bound with chronic stable multiple sclerosis. We injected botulinum toxin (400 mouse units) or placebo into the adductor muscles in a randomized, crossover, double‐blind design. Two physicians, who were unaware of the treatment order, used an objective rating scale and independently assessed the patients; interobserver correlation was excellent (r = 0.93‐0.81). We found that botulinum toxin produced a significant reduction in spasticity (p = 0.009) and a significant improvement in the ease of nursing care(p = 0.009). There were no adverse effects during this shortterm trial. This is the first demonstration of the beneficial effect of botulinum toxin on focal spastic muscle contractions.
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Cites
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PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS.
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DOUBLE-BLIND STUDY OF BOTULINUM TOXIN IN SPASMODIC TORTICOLLIS
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Self-citationIntrathecal Baclofen for Severe Spinal Spasticity
Penn, R. D., Savoy, S. M., Corcos, D., Latash, M., Gottlieb, G., Parke, B., & Kroin, J. S. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906083202303 · Cited by 754
PHENOTHIAZINE DYSKINESIA AFTER LEUCOTOMY
(1964) · The Lancet · doi:10.1016/s0140-6736(64)90197-7 · Cited by 397
Botulinum Toxin: Mechanism of Presynaptic Blockade
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Botulinum toxin in spasmodic torticollis.
Stell, R., Thompson, P. D., & Marsden, C. D. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.7.920 · Cited by 250
Effects of botulinum toxin injections on speech in adductor spasmodic dysphonia
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Cited by
National Clinical Guidelines for Stroke.
Robinson, T. (2001) · Postgraduate Medical Journal · doi:10.1136/pmj.77.906.286h · Cited by 608
Treatments for spasticity and pain in multiple sclerosis: a systematic review
Beard, S., Hunn, A., & Wight, J. (2003) · Health Technology Assessment · doi:10.3310/hta7400 · Cited by 266
Drugs Used to Treat Spasticity
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Metadata
- Authors
- Snow, B. J., Tsui, J. K. C., Bhatt, M. H., Varelas, M., Hashimoto, S. A., & Calne, D. B.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1990-10
- Volume
- 28
- Issue
- 4
- Pages
- 512-515
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1982567739
- Cited by
- 414
- References
- 12
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Snow, B. J., Tsui, J. K. C., Bhatt, M. H., Varelas, M., Hashimoto, S. A., & Calne, D. B. (1990). Treatment of spasticity with botulinum toxin: A double‐blind study. Annals of Neurology. https://doi.org/10.1002/ana.410280407
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
