A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease
Abstract
High dosages of a combination of alpha-tocopherol and ascorbate were administered to patients with early Parkinson's disease as an open-labeled trial and pilot study to test the endogenous toxic hypothesis of the etiology of Parkinson's disease. Patients receiving concomitant amantadine and anticholinergics were allowed to participate, but those receiving levodopa or dopamine agonists were not. The study was begun prior to the availability of deprenyl. The primary end point of the trial was progression of the disease until patients needed treatment with levodopa or a dopamine agonist. The time when levodopa became necessary in the treated patients was compared to another group of patients followed elsewhere who did not receive antioxidants. The time when levodopa became necessary was extended by 2.5 years in the group receiving alpha-tocopherol and ascorbate. Results of this pilot study suggest that the progression of Parkinson's disease may be slowed by administration of these antioxidants. Controlled clinical trials using double-blind randomization techniques are required to confirm these results.
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Concurrent intake of high doses of vitamin C and vitamin E delayed onset of treatment for more than 2 years in newly diagnosed PD patients.
“Concurrent intake of high doses of vitamin C and vitamin E (α-tocopherol) delayed the onset of treatment for more than 2 years in newly diagnosed PD patients (Fahn 1992).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Fahn 1992
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Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox
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- Authors
- Fahn, S.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Fahn, Stanley
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1992
- Volume
- 32
- Issue
- S1
- Pages
- S128-S132
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2112404451
- Cited by
- 211
- References
- 14
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 9 · 2013: 4 · 2012: 3
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- Parkinson's disease, alpha-tocopherol, vitamin C, antioxidants, disease progression, early-stage Parkinson's disease, amantadine, anticholinergic agents
- MeSH terms
- Adult, Aged, Ascorbic Acid, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Parkinson Disease, Pilot Projects, Research Design, Vitamin E
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