The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease
Abstract
Following the discovery of inhibition of electron transport complex I by the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), which produces a parkinsonian syndrome in humans, monkeys, and mice, several laboratories have reported abnormalities of complex I and other electron transport complexes (ETCs) in various tissues from patients with Parkinson's disease (PD). Criticism of the significance of these findings in the etiology of PD has centered on whether drug treatments or the debilitation of the disease process itself produced the low ETC activities. We present results from a blinded study of platelet mitochondrial ETC activities in 18 early untreated PD patients and 18 age‐ and sex‐matched controls and in 13 spousal controls. Lower complex I activity in platelet mitochondria of PD patients was seen in early untreated disease and thus cannot be due to debilitation or drug therapy. Home environmental factors seem an unlikely explanation for the reduced complex I activity in PD patients but have not been excluded. Complex II/III activity was also reduced by 20% in PD compared with age‐/sex‐matched controls. The low complex I and II/III activities in platelet mitochondria appear to be related to the etiology of PD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“An impairment of mitochondrial complex-I activity has been observed in the substantia nigra (SN), platelets, and skeletal muscle of PD patients 1, 9-13, in some but not in all studies14, 15.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [9]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914
Mitochondrial Complex I Deficiency in Parkinson's Disease
Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283
MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE
Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757
Abnormalities of the electron transport chain in idiopathic parkinson's disease
Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757
CENTRAL CERVICAL CORD SYNDROME AFTER HEADING A FOOTBALL
Scoppetta, C., & Vaccario, M. L. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92517-5 · Cited by 755
Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease
Mizuno, Y., Ohta, S., Tanaka, M., Takamiya, S., Suzuki, K., SATO, T. A., Oya, H., Ozawa, T., & Kagawa, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91141-8 · Cited by 735
Spectrophotometric Assay of Cytochrome c Oxidase
Smith, L. (1955) · Methods of biochemical analysis · doi:10.1002/9780470110188.ch13 · Cited by 506
Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients
Shoffner, J. M., Brown, M. D., Torroni, A., Lott, M. T., Cabell, M. F., Mirra, S. S., Beal, M. F., Yang, C.-C., Gearing, M., Salvo, R., et al. (1993) · Genomics · doi:10.1006/geno.1993.1299 · Cited by 450
Flagged first, then by citations
Research works printed but not linked: 1
- Lang AET, 1989, Quantification of neurological deficit, 289
Cited by
Sorted by citations
Items 101–200 of 434
Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients
Wen, J.-J., Yachelini, P., Sembaj, A., Manzur, R. E., & Garg, N. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.009 · Cited by 112
Coenzyme Q10 deficiency in patients with Parkinson's disease
Mischley, L. K., Allen, J., & Bradley, R. D. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.03.023 · Cited by 111
Kidd, P. M. (2000) · PubMed · Cited by 110
Mitochondria: A Therapeutic Target for Parkinson’s Disease?
Luo, Y., Hoffer, A., Hoffer, B. J., & Qi, X. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160920704 · Cited by 108
Esteves, A. R., Domingues, A. F., Ferreira, I. L., Januário, C., Swerdlow, R. H., Oliveira, C. R., & Cardoso, S. M. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.03.004 · Cited by 110
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome
Gómez, C. (2006) · Frontiers in bioscience · doi:10.2741/2128 · Cited by 104
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Wilkins, H. M., Weidling, I. W., Ji, Y., & Swerdlow, R. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00508 · Cited by 102
Platelets in Neurodegenerative Conditions—Friend or Foe?
Leiter, O., & Walker, T. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00747 · Cited by 102
Neuroproteomics: Expression Profiling of the Brain's Proteomes in Health and Disease
Kim, S. I., Voshol, H., van Oostrum, J., Hastings, T. G., Cascio, M., & Glucksman, M. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023618.35579.7c · Cited by 104
Mitochondrial Dysfunction in Idiopathic Parkinson Disease
Parker, W. D., & Swerdlow, R. H. (1998) · The American Journal of Human Genetics · doi:10.1086/301812 · Cited by 97
Jadiya, P., Garbincius, J. F., & Elrod, J. W. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01224-4 · Cited by 94
Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration
Cassano, T., Pace, L., Bedse, G., Lavecchia, A. M., Marco, F. D., Gaetani, S., & Serviddio, G. (2015) · Current Alzheimer Research · doi:10.2174/1567205013666151218132725 · Cited by 96
Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases
Fernández‐Moriano, C., González‐Burgos, E., & Gómez-Serranillos, M. P. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/408927 · Cited by 100
Altered redox state of platelet coenzyme Q 10 in Parkinson's disease
Götz, M. E., Gerstner, A., Harth, R., Dirr, A., Janetzky, B., Kuhn, W., Riederer, P., & Gerlach, M. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050003 · Cited by 93
Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease
Trancikova, A. K., Tsika, E., & Moore, D. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4200 · Cited by 94
Clark, J., & Simon, D. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2241 · Cited by 93
Arduíno, D. M., Esteves, A. R., Cardoso, S. M., & Oliveira, C. R. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.04.004 · Cited by 92
A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease
Shults, C. W., Haas, R., & Beal, M. F. (1999) · BioFactors · doi:10.1002/biof.5520090223 · Cited by 91
Self-citationRango, M., Bonifati, C., & Bresolin, N. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600192 · Cited by 91
Ghosh, S. S., Swerdlow, R. H., Miller, S. W., Sheeman, B., Parker, W. D., & DAVIS, R. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07825.x · Cited by 91
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
Esteves, A. R., Arduíno, D. M., Silva, D. F., Oliveira, C. R., & Cardoso, S. M. (2011) · Parkinson s Disease · doi:10.4061/2011/693761 · Cited by 90
Zaltieri, M., Longhena, F., Pizzi, M., Missale, C., Spano, P., & Bellucci, A. (2015) · Parkinson s Disease · doi:10.1155/2015/108029 · Cited by 95
A blood-based marker of mitochondrial DNA damage in Parkinson’s disease
Qi, R., Sammler, E. M., González-Hunt, C. P., Barraza, I., Pena, N., Rouanet, J. P., Naaldijk, Y., Goodson, S. D., Fuzzati, M., Blandini, F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abo1557 · Cited by 89
Aguirre, P., Urrutia, P. J., Tapia, V., Villa, M., Paris, I. B., Segura‐Aguilar, J., & Núñez, M. T. (2012) · BioMetals · doi:10.1007/s10534-012-9525-y · Cited by 89
Review: Iron metabolism and the role of iron in neurodegenerative disorders
Hadzhieva, M., Kirches, E., & Mawrin, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12096 · Cited by 90
Anemia or low hemoglobin levels preceding Parkinson disease: A case-control study
Savica, R., Grossardt, B. R., Carlin, J. M., Icen, M., Bower, J. H., Ahlskog, J. E., Maraganore, D. M., Steensma, D. P., & Rocca, W. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bd80c1 · Cited by 87
Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease
Chinta, S. J., & Andersen, J. K. (2010) · Free Radical Research · doi:10.3109/10715762.2010.509398 · Cited by 90
The multifaceted role of platelets in mediating brain function
Burnouf, T., & Walker, T. L. (2022) · Blood · doi:10.1182/blood.2022015970 · Cited by 86
Mitochondrial Inhibition and Oxidative Stress: Reciprocating Players in Neurodegeneration
Zeevalk, G. D., Bernard, L. P., Song, C., Gluck, M. J., & Ehrhart, J. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1117 · Cited by 89
Free radical theory of aging: Alzheimer’s disease pathogenesis
Harman, D. (1995) · AGE · doi:10.1007/bf02436085 · Cited by 87
Lim, L., Jackson-Lewis, V. R., Wong, L. C., Shui, G., Goh, A. X., Kesavapany, S., Jenner, A. M., Fivaz, M. L., Przedborski, S., & Wenk, M. R. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.105 · Cited by 83
Mitochondrial control of cell bioenergetics in Parkinson’s disease
Requejo-Aguilar, R., & Bolaños, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.012 · Cited by 87
DJ-1 knock-down impairs astrocyte mitochondrial function
Larsen, N. J., Ambrosi, G., Mullett, S. J., Berman, S. B., & Hinkle, D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.016 · Cited by 82
Patki, G., & Lau, Y. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.026 · Cited by 81
Mitochondrial medicine for neurodegenerative diseases
Du, H., & Yan, S. S. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.004 · Cited by 82
Bharath, S., Cochran, B. C., Hsu, M., Liu, J., Ames, B. N., & Andersen, J. K. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00035-9 · Cited by 81
Calcium, Bioenergetics, and Parkinson’s Disease
Zampese, E., & Surmeier, D. J. (2020) · Cells · doi:10.3390/cells9092045 · Cited by 79
Recent developments in the molecular genetics of mitochondrial disorders
Graeber, M. B., & Müller, U. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00295-5 · Cited by 79
Coenzyme Q treatment of neurodegenerative diseases of aging
Galpern, W. R., & Cudkowicz, M. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.01.004 · Cited by 78
Coenzyme Q10 a mitochondrial restorer for various brain disorders
Pradhan, N., Singh, C., & Singh, A. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02161-8 · Cited by 79
Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients
Winkler‐Stuck, K., Wiedemann, F. R., Wallesch, C., & Kunz, W. S. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.02.003 · Cited by 77
Therapeutic role of coenzyme Q10 in Parkinson's disease
Shults, C. W. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.02.002 · Cited by 81
Self-citationShahrani, M. M. A., Heales, S., Hargreaves, I. P., & Orford, M. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6110100 · Cited by 79
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities
Izzi, B., Tirozzi, A., Cerletti, C., Donati, M. B., de Gaetano, G., Hoylaerts, M., Iacoviello, L., & Gialluisi, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228817 · Cited by 79
Decreased NADH dehydrogenase and ubiquinol-cytochromecoxidoreductase in peripheral arterial disease
Brass, E. P., Hiatt, W. R., Gardner, A. W., & Hoppel, C. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h603 · Cited by 75
Chinopoulos, C., & Ádám‐Vizi, V. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00060.x · Cited by 73
SUMO ‐regulated mitochondrial function in Parkinson's disease
Souza, A. C. G., Prediger, R. D., & Cimarosti, H. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13599 · Cited by 78
Loesch, D. Z., Godler, D. E., Evans, A. H., Bui, M., Gehling, F., Kotschet, K. E., Trost, N. M., Storey, E., Stimpson, P., Kinsella, G., et al. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e3182064362 · Cited by 71
The multi‐faceted role of mitochondria in the pathology of Parkinson’s disease
Trinh, D., Israwi, A. R., Arathoon, L. R., Gleave, J. A., & Nash, J. E. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15154 · Cited by 74
Succinate dehydrogenase: Prospect for neurodegenerative diseases
Farshbaf, M. J., & Kiani‐Esfahani, A. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.12.002 · Cited by 71
Pienaar, I. S., Elson, J. L., Racca, C., Nelson, G., Turnbull, D. M., & Morris, C. M. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.002 · Cited by 71
Parkinson’s disease and mitochondrial complex I: a perspective on the Ndi1 therapy
Marella, M., Seo, B. B., Yagi, T., & Matsuno‐Yagi, A. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9249-z · Cited by 69
Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L. M., Negri, G. L., Schwamborn, J. C., Jensen, P. H., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0554-9 · Cited by 66
Chronic treatment of mitochondrial disease patients with dichloroacetate
Barshop, B. A., Naviaux, R. K., McGowan, K. A., Levine, F., Nyhan, W. L., Loupis-Geller, A., & Haas, R. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.06.009 · Cited by 66
Self-citationMitochondrial DNA sequence variation in multiple sclerosis
Tranah, G. J., Santaniello, A., Caillier, S. J., D’Alfonso, S., Boneschi, F. M., Hauser, S. L., & Oksenberg, J. R. (2015) · Neurology · doi:10.1212/wnl.0000000000001744 · Cited by 66
Vulnerability of mesostriatal dopaminergic neurons in Parkinson’s disease
González-Hernández, T. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00140 · Cited by 65
Mitochondrial Importance in Alzheimer’s, Huntington’s and Parkinson’s Diseases
Correia, S. C., Santos, R. X., Perry, G. L., Zhu, X., Moreira, P. I., & Smith, M. A. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0653-2_16 · Cited by 65
Jiménez-Delgado, A., Ortíz, G. G., Delgado-Lara, D. L. C., González-Usigli, H., González-Ortiz, L. J., Cid-Hernández, M., Serrano, J. A. C., & Pacheco-Moisés, F. P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5577541 · Cited by 65
Donatti, A., do Canto, A. M., Godoi, A. B., da Rosa, D. C., & Lopes‐Cendes, Í. (2020) · Metabolites · doi:10.3390/metabo10100389 · Cited by 69
Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
Faustini, G., Bono, F., Valerio, A., Pizzi, M., Spano, P., & Bellucci, A. (2017) · Genes · doi:10.3390/genes8120377 · Cited by 66
Damodaran, T. V., Patel, A. G., Greenfield, S. T., Dressman, H. K., Lin, S. M., & Abou-Donia, M. B. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.051 · Cited by 62
Rahimifard, M., Baeeri, M., Bahadar, H., Moini-Nodeh, S., Khalid, M., Haghi-Aminjan, H., Mohammadian, H., & Abdollahi, M. (2020) · Molecules · doi:10.3390/molecules25245875 · Cited by 61
RetractedFoti, S. C., Hargreaves, I. P., Carrington, S., Kiely, A. P., Houlden, H., & Holton, J. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-42902-7 · Cited by 58
Alpha synuclein in hematopoiesis and immunity
Pei, Y., & Maitta, R. W. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02590 · Cited by 62
Coenzyme Q10 effects in neurological diseases
Rauchová, H. (2021) · Physiological Research · doi:10.33549/physiolres.934712 · Cited by 68
Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease
Ambrosi, G., Ghezzi, C., Sepe, S., Milanese, C., Payán‐Gómez, C., Bombardieri, C. R., Armentero, M., Zangaglia, R., Pacchetti, C., Mastroberardino, P. G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.008 · Cited by 60
Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity
Mook‐Jung, I., Shin, J., Yun, S. H., Huh, K., Koh, J. Y., Park, H. K., Jew, S., & Jung, M. W. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991101)58:3 · Cited by 140
Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease
Beal, M. F., & Shults, C. W. (2003) · BioFactors · doi:10.1002/biof.5520180218 · Cited by 60
Self-citationMitochondrial preconditioning: a potential neuroprotective strategy
Correia, S. C. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00138 · Cited by 58
Choi, H. J., Lee, S. Y., Cho, Y., No, H., Kim, S. W., & Hwang, O. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.10.011 · Cited by 58
Laar, V. S. V., Chen, J., Zharikov, A., Bai, Q., Maio, R. D., Dukes, A. A., Hastings, T. G., Watkins, S. C., Greenamyre, J. T., Croix, C. M. S., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101695 · Cited by 56
The Neuroprotective Role of Creatine
Klein, A., & Ferrante, R. J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6486-9_11 · Cited by 56
Mitochondrial Dysfunction in Parkinson’s Disease: Focus on Mitochondrial DNA
Бунеева, О. А., Fedchenko, V. I., Kopylov, A. T., & Medvedev, A. E. (2020) · Biomedicines · doi:10.3390/biomedicines8120591 · Cited by 60
The coenzyme Q10 status of the brain regions of Parkinson’s disease patients
Hargreaves, I. P., Lane, A., & Abou‐Sleiman, P. M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.069 · Cited by 56
KONES, R. J. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533610373932 · Cited by 57
L ‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease
Tieu, K., Perier, C., Vila, M., Caspersen, C. S., Zhang, H., Teismann, P., Jackson-Lewis, V. R., Stern, D. M., Yan, S. D., & Przedborski, S. (2004) · Annals of Neurology · doi:10.1002/ana.20133 · Cited by 55
POLG1 polyglutamine tract variants associated with Parkinson's disease
Eerola, J., Luoma, P. T., Peuralinna, T., Scholz, S. W., Paisán‐Ruiz, C., Suomalainen, A., Singleton, A., & Tienari, P. J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.04.021 · Cited by 54
Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
Bu, X., Wu, D., Lu, X., Yang, L., Xu, X., Wang, J., & Tang, J. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s129081 · Cited by 54
Mitochondrial Sirtuins in Parkinson’s Disease
He, L., Wang, J., Yang, Y., Li, J., & Tu, H. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03560-w · Cited by 55
Involvement of Mitochondria in Parkinson’s Disease
Choong, C., & Mochizuki, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242317027 · Cited by 58
Mitochondrial DNA polymorphisms in pathologically proven Parkinson’s disease
Bandmann, O., Sweeney, M. G., Daniel, S. E., MARSDEN, C. D., & Wood, N. W. (1997) · Journal of Neurology · doi:10.1007/s004150050082 · Cited by 53
Stack, E. C., Ferro, J. L., Kim, J.-H., Signore, S. J. D., Goodrich, S., Matson, S. A., Hunt, B. B., Cormier, K., Smith, K., Matson, W. R., et al. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.12.006 · Cited by 53
Considerations on the role of environmental toxins in idiopathic Parkinson’s disease pathophysiology
Pan-Montojo, F. J., & Reichmann, H. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-10 · Cited by 54
Metabolomics of Neurodegenerative Diseases
Botas, A., Campbell, H. M., Han, X., & Maletić‐Savatić, M. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.05.006 · Cited by 52
Reduced platelet glutamate uptake in Parkinson's disease
Ferrarese, C., Zoia, C., Pecora, N., Piolti, R., Frigo, M., Bianchi, G., Sala, G., Begni, B., Riva, R., & Frattola, L. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050189 · Cited by 51
Mitochondrial DNA–Related Mitochondrial Dysfunction in Neurodegenerative Diseases
Swerdlow, R. H. (2002) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2002-126-0271-mdrmdi · Cited by 50
Oxidative stress in skin fibroblasts cultures from patients with Parkinson's disease
del Hoyo, P., García‐Redondo, A., Bustos, F., Molina, J. A., Sayed, Y., Alonso‐Navarro, H., Caballero, L., Arenas, J., Agúndez, J. A. G., & Jiménez‐Jiménez, F. J. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-95 · Cited by 50
Subrahmanian, N., & LaVoie, M. J. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147434 · Cited by 48
Kuntić, M., Hahad, O., Münzel, T. F., & Daiber, A. (2024) · Antioxidants · doi:10.3390/antiox13030266 · Cited by 53
Liao, K., Yan, J., Mai, K., & Ai, Q. (2015) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2015.11.012 · Cited by 49
Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits
Zhou, L., Wang, W., Hoppel, C. L., Liu, J., & Zhu, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.032 · Cited by 49
Genetics, drugs and environmental factors in Parkinson's disease: a case-control study
Werneck, A. L. D. S., & Alvarenga, H. (1999) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x1999000300001 · Cited by 49
Selective basal ganglia vulnerability to energy deprivation: Experimental and clinical evidences
Tambasco, N., Romoli, M., & Calabresi, P. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.07.003 · Cited by 48
Choi, W., Kim, H.-W., Tronche, F., Palmiter, R. D., Storm, D. R., & Xia, Z. (2017) · Scientific Reports · doi:10.1038/srep44989 · Cited by 49
Role of platelet in Parkinson’s disease: Insights into pathophysiology & theranostic solutions
Beura, S. K., Panigrahi, A. R., Yadav, P., & Singh, S. K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101681 · Cited by 47
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness
Cieri, D., Brini, M., & Calí, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.153 · Cited by 50
Blood-based bioenergetics: An emerging translational and clinical tool
Braganza, A., Annarapu, G. K., & Shiva, S. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.100835 · Cited by 47
Peripheral markers of oxidative stress in Parkinson’s disease. the role of L-DOPA
Martignoni, E., Blandini, F., Godi, L., Desideri, S., Pacchetti, C., Mancini, F., & Nappi, G. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00075-1 · Cited by 47
Genetic aspects of Parkinson's disease
Bandmann, O., MARSDEN, C. D., & Wood, N. W. (1998) · Movement Disorders · doi:10.1002/mds.870130203 · Cited by 47
Serviddio, G., Romano, A. D., Cassano, T., Bellanti, F., Altomare, E., & Vendemiale, G. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796904740 · Cited by 45
Metadata
- Authors
- Haas, R. H., Nasirian, F., Nakano, K., Ward, D., Pay, M., Hill, R., & Shults, C. W.
- Affiliations
- University of California San Diego (US)
- Veterans Health Administration (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1995-06
- Volume
- 37
- Issue
- 6
- Pages
- 714-722
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2112777355
- Cited by
- 435
- References
- 47
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 19 · 2019: 23 · 2018: 13 · 2017: 18 · 2016: 8 · 2015: 22 · 2014: 9 · 2013: 15 · 2012: 11
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns029504-03)
- National Institute of Neurological Disorders and Stroke (R01 NS29504)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- Parkinson's disease, platelet mitochondria, mitochondrial electron transport chain, complex I, MPTP, etiology, mitochondrial dysfunction
- MeSH terms
- Adult, Aged, Blood Platelets, Citrate (si)-Synthase, Female, Humans, Male, Middle Aged, Mitochondria, Multienzyme Complexes, Oxidoreductases, Parkinson Disease, Smoking, Succinate Dehydrogenase, Electron Transport Complex III, NAD(P)H Dehydrogenase (Quinone), Electron Transport Complex II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review