Vulnerability of mesostriatal dopaminergic neurons in Parkinson’s disease

Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal

Ndiaye, M., Lespez, L., Tribolo, C., Rassé, M., Hadjas, I., Davidoux, S., Huysecom, É., & Douze, K. (2024) · Monash University Research Portal (Monash University) · doi:10.3929/ethz-b-000667478 · Cited by 24,015 · see citing works

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914 · see citing works

α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110 · see citing works

Cloned Glutamate Receptors

Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529 · see citing works

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

Conn, P. J., & Pin, J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.205 · Cited by 3,083 · see citing works

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works

Getting formal with dopamine and reward

Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Paisán‐Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simón, J., van der Brug, M., de Munaín, A. L., Aparicio, S. F., Gil, A. M., Khan, N. L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.023 · Cited by 2,416 · see citing works

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283 · see citing works

Oxidative stress in Parkinson's disease

Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.

Limousin, P., Krack, P., Pollak, P., Benazzouz, A., Ardouin, C., Hoffmann, D., & Benabid, A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810153391603 · Cited by 2,030 · see citing works

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · see citing works

Neuroinflammation in Parkinson’s disease: A target for neuroprotection?

Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984 · see citing works

The substantia nigra of the human brain

Damier, P., Hirsch, É. C., Agid, Y., & Graybiel, A. M. (1999) · Brain · doi:10.1093/brain/122.8.1437 · Cited by 1,772 · see citing works

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757 · see citing works

The ubiquitin pathway in Parkinson's disease

Leroy, E., Boyer, R., Auburger, G. W. J., Leube, B., Ulm, G., Mezey, É., Harta, G., Brownstein, M., Jonnalagada, S., Chernova, T., et al. (1998) · Nature · doi:10.1038/26652 · Cited by 1,572 · see citing works

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570 · see citing works

Neuropathology of Parkinson's Disease

Forno, L. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199603000-00001 · Cited by 1,556 · see citing works

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Conway, K. A., Lee, S., Rochet, J., Ding, T. T., Williamson, R. E., & Lansbury, P. T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.571 · Cited by 1,543 · see citing works

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

McCormack, J. G., Halestrap, A. P., & Denton, R. M. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.391 · Cited by 1,398 · see citing works

The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism

Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. R. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.507 · Cited by 1,366 · see citing works

Alzheimer's Disease and Parkinson's Disease

Nussbaum, R. L., & Ellis, C. E. (2003) · New England Journal of Medicine · doi:10.1056/nejm2003ra020003 · Cited by 1,351 · see citing works

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · see citing works

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

Geiger, J. R. P., Melcher, T., Koh, D.-S., Sakmann, B., Seeburg, P. H., Jonas, P., & Monyer, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90076-4 · Cited by 1,260 · see citing works

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works

Tyrosinase: a comprehensive review of its mechanism

Sánchez‐Ferrer, Á., Rodríguez‐López, J. N., Garcı́a-Cánovas, F., & García‐Carmona, F. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(94)00204-t · Cited by 1,244 · see citing works

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works

Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences

Rizzuto, R., & Pozzan, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,201 · see citing works

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115 · see citing works

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

Devi, L., Raghavendran, V., Prabhu, B. M., Avadhani, N. G., & Anandatheerthavarada, H. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710012200 · Cited by 1,087 · see citing works

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

Burnashev, N., Monyer, H., Seeburg, P. H., & Sakmann, B. (1992) · Neuron · doi:10.1016/0896-6273(92)90120-3 · Cited by 1,087 · see citing works

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin

Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., & Takahashi, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00407-x · Cited by 1,050 · see citing works

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · see citing works

Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases

Zarow, C., Lyness, S. A., Mortimer, J. A., & Chui, H. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.337 · Cited by 1,003 · see citing works

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

Palacino, J. J., Sagi, D., Goldberg, M. S., Krauss, S., Motz, C., Wacker, M., Klose, J., & Shen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401135200 · Cited by 995 · see citing works

Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986 · see citing works

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Zhang, Y., Gao, J., Chung, K. K. K., Huang, H., Dawson, V. L., & Dawson, T. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240347797 · Cited by 982 · see citing works

The endoplasmic reticulum: a multifunctional signaling organelle

Berridge, M. J. (2002) · Cell Calcium · doi:10.1016/s0143416002001823 · Cited by 978 · see citing works

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

LaFerla, F. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn960 · Cited by 970 · see citing works

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

Novelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961 · see citing works

‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease

Chan, C. S., Guzmán, J. N., Ilijić, E., Mercer, J. N., Rick, C., Tkatch, T., Meredith, G. E., & Surmeier, D. J. (2007) · Nature · doi:10.1038/nature05865 · Cited by 899 · see citing works

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 884 · see citing works

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883 · see citing works

Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients

Mogi, M., Harada, M., Kondo, T., Riederer, P., Inagaki, H., Minami, M., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90508-8 · Cited by 855 · see citing works

DJ‐1 has a role in antioxidative stress to prevent cell death

Taira, T., Saito, Y., Niki, T., Iguchi‐Ariga, S. M. M., Takahashi, K., & Ariga, H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400074 · Cited by 852 · see citing works

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

McCormack, A. L., Thiruchelvam, M. J., Manning-Bog, A., Thiffault, C., Langston, J. W., Cory‐Slechta, D. A., & Monte, D. A. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838 · see citing works

The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems

Gerfen, C. R., Herkenham, M. A., & Thibault, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-12-03915.1987 · Cited by 804 · see citing works

A highly reproducible rotenone model of Parkinson's disease

Cannon, J. R., Tapias, V., Na, H. M., Honick, A. S., Drolet, R. E., & Greenamyre, J. T. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.016 · Cited by 802 · see citing works

α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

Lashuel, H. A., Petre, B. M., Wall, J. S., Simon, M. N., Nowak, R. J., Walz, T., & Lansbury, P. T. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00735-0 · Cited by 802 · see citing works

Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0766-2 · Cited by 791 · see citing works

Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled

Keeney, P., Xie, J., Capaldi, R., & Bennett, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-06.2006 · Cited by 757 · see citing works

Toxin-induced models of Parkinson’s disease

Bové, J., Prou, D., Perier, C., & Przedborski, S. (2005) · NeuroRX · doi:10.1602/neurorx.2.3.484 · Cited by 739 · see citing works

Dopamine covalently modifies and functionally inactivates parkin

LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722 · see citing works

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E. M., Sisk, A., Mallory, M. E., Wong, J., Takenouchi, T., Hashimoto, M., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64553-1 · Cited by 716 · see citing works

Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

Sherer, T., Kim, J.-H., Betarbet, R. S., & Greenamyre, J. T. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8072 · Cited by 707 · see citing works

Back to the Future with Ubiquitin

Pickart, C. M. (2004) · Cell · doi:10.1016/s0092-8674(03)01074-2 · Cited by 699 · see citing works

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Gautier, C. A., Kitada, T., & Shen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802076105 · Cited by 698 · see citing works

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

Kim, R. H., Smith, P. D., Aleyasin, H., Hayley, S. P., Mount, M. P., Pownall, S., Wakeham, A. C., You-Ten, A. J., Kalia, S. K., Horne, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501282102 · Cited by 697 · see citing works

Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L., & Lee, M. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4308-05.2006 · Cited by 684 · see citing works

Dopamine Oxidation Alters Mitochondrial Respiration and Induces Permeability Transition in Brain Mitochondria

Berman, S. B., & Hastings, T. G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731127.x · Cited by 664 · see citing works

Aging and Extrapyramidal Function

McGeer, P. L., McGeer, E. G., & Suzuki, J. S. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500130053010 · Cited by 648 · see citing works

Origin and functional consequences of the complex I defect in Parkinson's disease

Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638 · see citing works

The neostriatal mosaic: compartmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey.

Gerfen, C. R., Baimbridge, K. G., & Miller, J. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8780 · Cited by 636 · see citing works

Environmental risk factors and Parkinson's disease

Liou, H., Tsai, M.-C., Chen, C., Jeng, J., Chang, Y. C., Chen, S. Y., & Chen, R.-T. (1997) · Neurology · doi:10.1212/wnl.48.6.1583 · Cited by 616 · see citing works

PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Pridgeon, J. W., Olzmann, J. A., Chin, L.-S., & Li, L. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050172 · Cited by 596 · see citing works

Nitric oxide synthase and neuronal vulnerability in parkinson's disease

Hunot, S., Boissière, F., Faucheux, B., Brugg, B., Mouatt-Prigent, A., Agid, Y., & Hirsch, E. C. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00578-1 · Cited by 595 · see citing works

Efferent projections of the subthalamic nucleus in the rat: Light and electron microscopic analysis with the PHA‐L method

Kita, H., & Kitai, S. T. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902600309 · Cited by 591 · see citing works

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease

Boka, G., Anglade, P., Wallach, D., Javoy-Agid, F., Agid, Y., & Hirsch, É. C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90684-x · Cited by 591 · see citing works

DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation

Shendelman, S., Jonason, A. S., Martinat, C., Leete, T., & Abeliovich, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020362 · Cited by 588 · see citing works

The Origin and Neuronal Function ofIn VivoNonsynaptic Glutamate

Baker, D. L., Xi, Z., Shen, H., Swanson, C. J., & Kalivas, P. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09134.2002 · Cited by 584 · see citing works

Molecular characterization of the dopamine transporter.

Giros, B., & Caron, M. (1993) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90029-j · Cited by 582 · see citing works

The substantia nigra of the human brain

Damier, P., Hirsch, É. C., Agid, Y., & Graybiel, A. M. (1999) · Brain · doi:10.1093/brain/122.8.1421 · Cited by 579 · see citing works

Altered proteasomal function in sporadic Parkinson’s disease

St. P. McNaught, K., Belizaire, R., Isacson, O., Jenner, P., & Olanow, C. W. (2003) · Experimental Neurology · doi:10.1006/exnr.2002.8050 · Cited by 573 · see citing works

Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

Stefanis, L., Larsen, K. E., Rideout, H. J., Sulzer, D. L., & Greene, L. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09549.2001 · Cited by 569 · see citing works

Hypocretin (orexin) cell loss in Parkinson's disease

Thannickal, T. C., Lai, Y.-Y., & Siegel, J. M. (2007) · Brain · doi:10.1093/brain/awm097 · Cited by 566 · see citing works

Rate of cell death in parkinsonism indicates active neuropathological process

McGeer, P. L., Itagaki, S., Akiyama, H., & McGeer, E. G. (1988) · Annals of Neurology · doi:10.1002/ana.410240415 · Cited by 557 · see citing works

DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers

Lippa, C. F., Duda, J. E., Grossman, M., Hurtig, H. I., Aarsland, D., Boeve, B. F., Brooks, D. J., Dickson, D. W., Dubois, B., Emre, M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000256715.13907.d3 · Cited by 548 · see citing works

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

Pan, T., Kondo, S., Le, W., & Jankovic, J. J. (2008) · Brain · doi:10.1093/brain/awm318 · Cited by 546 · see citing works

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Goldberg, M. S., Pisani, A., Haburčák, M., Vortherms, T. A., Kitada, T., Costa, C., Tong, Y., Martella, G., Tscherter, A., Martins, A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.041 · Cited by 532 · see citing works

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

Di Fonzo, A., Rohé, C. F., Ferreira, J., Chien, H. F., Vacca, L., Stocchi, F., Guedes, L., Fabrizio, E., Manfredi, M., Vanacore, N., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17829-5 · Cited by 531 · see citing works

Inflammation and the Degenerative Diseases of Aging

McGeer, P. L., & McGeer, E. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.007 · Cited by 519 · see citing works

Failure of the ubiquitin-proteasome system in Parkinson’s disease

McNaught, K. S. P., Olanow, C. W., Halliwell, B., Isacson, O., & Jenner, P. (2001) · Nature Reviews Neuroscience · doi:10.1038/35086067 · Cited by 519 · see citing works

Oxidative stress and protein aggregation during biological aging

Squier, T. C. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00139-5 · Cited by 511 · see citing works

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Biskup, S., Moore, D. J., Celsi, F., Higashi, S., West, A. B., Andrabi, S. A., Kurkinen, K. M. A., Yu, S., Savitt, J. M., Waldvogel, H. J., et al. (2006) · Annals of Neurology · doi:10.1002/ana.21019 · Cited by 511 · see citing works

PINK1 mutations are associated with sporadic early‐onset parkinsonism

Valente, E. M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A. E., Caputo, V., Romito, L. M., Albanese, A., Dallapiccola, B., & Bentivoglio, A. R. (2004) · Annals of Neurology · doi:10.1002/ana.20256 · Cited by 506 · see citing works

Inflammatory Regulators in Parkinson's Disease: iNOS, Lipocortin-1, and Cyclooxygenases-1 and -2

Knott, C., Stern, G., & Wilkin, G. P. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0914 · Cited by 503 · see citing works

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

Tanaka, Y. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.9.919 · Cited by 497 · see citing works

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

Gloeckner, C. J., Kinkl, N., Schumacher, A., Braun, R. J., O’Neill, E. E., Meitinger, T., Kölch, W., Prokisch, H., & Ueffing, M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi439 · Cited by 477 · see citing works

Parkinson's disease and exposure to agricultural work and pesticide chemicals

Semchuk, K., Love, E., & Lee, R. (1992) · Neurology · doi:10.1212/wnl.42.7.1328 · Cited by 471 · see citing works

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

Sulzer, D. L., Bogulavsky, J. J., Larsen, K. E., Behr, G. G., Karatekin, E., Kleinman, M. H., Turro, N. J., Krantz, D. E., Edwards, R. H., Greene, L. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11869 · Cited by 460 · see citing works

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

Silvestri, L., Caputo, V., Bellacchio, E., Atorino, L., Dallapiccola, B., Valente, E. M., & Casari, G. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi377 · Cited by 449 · see citing works

Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K

Yamada, T., McGeer, P. L., Baimbridge, K. G., & McGeer, E. G. (1990) · Brain Research · doi:10.1016/0006-8993(90)91236-a · Cited by 448 · see citing works

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

Haas, R. H., Nasirian, F., Nakano, K., Ward, D., Pay, M., Hill, R., & Shults, C. W. (1995) · Annals of Neurology · doi:10.1002/ana.410370604 · Cited by 435 · see citing works

Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

Banati, R. B., Daniel, S. E., & Blunt, S. B. (1998) · Movement Disorders · doi:10.1002/mds.870130205 · Cited by 430 · see citing works

Ageing, neurodegeneration and Parkinson's disease

Hindle, J. V. (2010) · Age and Ageing · doi:10.1093/ageing/afp223 · Cited by 430 · see citing works

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Takahashi, N., Miner, L. L., Sora, I., Ujike, H., Revay, R. S., Kostić, V., Jackson-Lewis, V. R., Przedborski, S., & Uhl, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9938 · Cited by 429 · see citing works

Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function

Snyder, H. M., Mensah, K., Theisler, C. M., Lee, J., Matouschek, A. T., & Wolozin, B. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208641200 · Cited by 420 · see citing works

Mitochondrial membrane permeabilization in neuronal injury

Galluzzi, L., Blomgren, K., & Kroemer, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2665 · Cited by 418 · see citing works

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 418 · see citing works

Degradation of α-Synuclein by Proteasome

Bennett, M. C., Bishop, J. F., Leng, Y., Chock, P. B., Chase, T. N., & Mouradian, M. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33855 · Cited by 417 · see citing works

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

Darios, F. D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg044 · Cited by 401 · see citing works

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003) · Annals of Neurology · doi:10.1002/ana.10728 · Cited by 400 · see citing works

Midbrain dopaminergic cell loss in parkinson's disease: Computer visualization

German, D. C., Manaye, K. F., Smith, W. K., Woodward, D. J., & Saper, C. B. (1989) · Annals of Neurology · doi:10.1002/ana.410260403 · Cited by 396 · see citing works

Neuronal degeneration and mitochondrial dysfunction

Schon, E. A., & Manfredi, G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17741 · Cited by 393 · see citing works

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

Kim, Y. S., Park, J., Kim, S., Song, S., Kwon, S., Lee, S., Kitada, T., Kim, J., & Chung, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.104 · Cited by 389 · see citing works

Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration

Caudle, W. M., Richardson, J. R., Wang, M. Z., Taylor, T. N., Guillot, T. S., McCormack, A. L., Colebrooke, R. E., Monte, D. A. D., Emson, P. C., & Miller, G. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-07.2007 · Cited by 389 · see citing works

Complex I deficiency in Parkinson's disease frontal cortex

Parker, W. D., Parks, J. K., & Swerdlow, R. H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.061 · Cited by 383 · see citing works

Animal Models of Action Tremor

Elble, R. J. (2008) · Movement Disorders · doi:10.1002/mds.870131306 · Cited by 381 · see citing works

The role of pathogenic DJ‐1 mutations in Parkinson's disease

Abou‐Sleiman, P. M., Healy, D. G., Quinn, N. P., Lees, A. J., & Wood, N. W. (2003) · Annals of Neurology · doi:10.1002/ana.10675 · Cited by 381 · see citing works

A critical evaluation of the Braak staging scheme for Parkinson's disease

Burke, R. E., Dauer, W. T., & Vonsattel, J. P. (2008) · Annals of Neurology · doi:10.1002/ana.21541 · Cited by 377 · see citing works

A comparison of clinical and pathological features of young‐ and old‐onset Parkinson's disease

Gibb, W. R. G., & Lees, A. J. (1988) · Neurology · doi:10.1212/wnl.38.9.1402 · Cited by 371 · see citing works

Dopamine transporters and neuronal injury

Miller, G. W., Gainetdinov, R. R., Levey, A. I., & Caron, M. G. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01379-6 · Cited by 371 · see citing works

Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection

Chung, C. Y., Seo, H., Sonntag, K. C., Brooks, A., Lin, L., & Isacson, O. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi178 · Cited by 361 · see citing works

Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase

Hastings, T. G. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020919.x · Cited by 359 · see citing works

Platelet mitochondria function in Parkinson's disease

Krige, D., Carroll, M. T., Cooper, J. A. D., MARSDEN, C. D., & Schapira, A. H. V. (1992) · Annals of Neurology · doi:10.1002/ana.410320612 · Cited by 358 · see citing works

Motor Score of the Unified Parkinson Disease Rating Scale as a Good Predictor of Lewy Body–Associated Neuronal Loss in the Substantia Nigra

Greffard, S., Verny, M., Bonnet, A.-M., Beinis, J., Gallinari, C., Meaume, S., Piette, F., Hauw, J., & Duyckaerts, C. J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.4.584 · Cited by 355 · see citing works

Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter

Gainetdinov, R. R., Fumagalli, F., Jones, S. R., & Caron, M. G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031322.x · Cited by 353 · see citing works

Lysosomal Degradation of α-Synuclein in Vivo

Mak, S. K., McCormack, A. L., Manning-Bog, A., Cuervo, A. M., & Monte, D. A. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074617 · Cited by 349 · see citing works

Activation of microglia by human neuromelanin is NF‐κB‐dependent and involves p38 mitogen‐activated protein kinase: implications for Parkinson's disease

Wilms, H., Rosenstiel, P. C., Sievers, J., Deuschl, G., Zecca, L., & Lucius, R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0314fje · Cited by 337 · see citing works

Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease

Benazzouz, A., Breit, S., Koudsié, A., Pollak, P., Krack, P., & Benabid, A. (2002) · Movement Disorders · doi:10.1002/mds.10156 · Cited by 337 · see citing works

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

Höglinger, G. U., Féger, J., Prigent, A., Michel, P. P., Parain, K., Champy, P., Ruberg, M., Oertel, W. H., & Hirsch, É. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01533.x · Cited by 331 · see citing works

Neuronal degeneration and mitochondrial dysfunction

Schon, E. A., & Manfredi, G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317741 · Cited by 326 · see citing works

Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

Celsi, F., Pizzo, P., Brini, M., Leo, S., Fotino, C., Pinton, P., & Rizzuto, R. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.02.021 · Cited by 321 · see citing works

Midbrain Dopaminergic Cell Loss in Parkinson's Disease and MPTP‐Induced Parkinsonism: Sparing of Calbindin‐D25k—Containing Cellsa

German, D. C., Manaye, K. F., Sonsalla, P. K., & Brooks, B. A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb24523.x · Cited by 319 · see citing works

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A. S. Y., Miljan, E. A., Keen, G., Stanyer, L., Hargreaves, I., Klupsch, K., Deas, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002455 · Cited by 316 · see citing works

DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi‐Ariga, S. M. M., & Ariga, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101730200 · Cited by 313 · see citing works

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

Cicchetti, F., Drouin‐Ouellet, J., & Gross, R. E. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.005 · Cited by 312 · see citing works

How much phenotypic variation can be attributed to parkin genotype?

Lohmann, E., Periquet, M., Bonifati, V., Wood, N. W., Michele, G. D., Bonnet, A., Fraix, V., Broussolle, E., Horstink, M. W. I. M., Vidailhet, M., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10613 · Cited by 300 · see citing works

Calcium, ageing, and neuronal vulnerability in Parkinson's disease

Surmeier, D. J. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70246-6 · Cited by 297 · see citing works

Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP + Binds to Neuromelanin

D’Amato, R. J., Lipman, Z. P., & Snyder, S. H. (1986) · Science · doi:10.1126/science.3080808 · Cited by 296 · see citing works

The anterior olfactory nucleus in Parkinson's disease

Pearce, R. K. B., Hawkes, C. H., & Daniel, S. E. (1995) · Movement Disorders · doi:10.1002/mds.870100309 · Cited by 289 · see citing works

Iron‐Melanin Interaction and Lipid Peroxidation: Implications for Parkinson's Disease

Ben‐Shachar, D., Riederer, P. F., & Youdim, M. B. H. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb06358.x · Cited by 287 · see citing works

Neural mechanisms of reward-related motor learning

Wickens, J. R., Reynolds, J. N., & Hyland, B. I. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.10.013 · Cited by 284 · see citing works

Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain

Mogi, M., Togari, A., Kondo, T., Mizuno, Y., Komure, O., Kuno, S., Ichinose, H., & Nagatsu, T. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050028 · Cited by 283 · see citing works

Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works

Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity

Taylor, T. N., Caudle, W. M., Shepherd, K. R., Noorian, A. R., Jackson, C. R., Iuvone, P. M., Weinshenker, D., Greene, J. G., & Miller, G. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1495-09.2009 · Cited by 278 · see citing works

Aggresome‐related biogenesis of Lewy bodies

McNaught, K. S. P., Shashidharan, P., Perl, D. P., Jenner, P. G., & Olanow, C. W. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02301.x · Cited by 277 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Aging Produces a Specific Pattern of Striatal Dopamine Loss: Implications for the Etiology of Idiopathic Parkinson's Disease

Kish, S. J., Shannak, K. S., Rajput, A. H., Deck, J. H. N., & Hornykiewicz, O. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09766.x · Cited by 272 · see citing works

Aging: A Theory Based on Free Radical and Radiation Chemistry

Harman, D. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.37.cp14 · Cited by 267 · see citing works

Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function

Olzmann, J. A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L., & Chin, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311017200 · Cited by 266 · see citing works

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

Zecca, L., Zucca, F. A., Wilms, H., & Sulzer, D. L. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.009 · Cited by 265 · see citing works

Epidemiology of Parkinson’s Disease

Chade, A., Kasten, M., & Tanner, C. M. (2007) · CRC Press eBooks · doi:10.3109/9781420019223-6 · Cited by 264 · see citing works

Endoplasmic reticulum stress response and neurodegeneration

Paschen, W., & Mengesdorf, T. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.019 · Cited by 252 · see citing works

Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area

Omelchenko, N., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20417 · Cited by 252 · see citing works

Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism

Bas, J. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00422-7 · Cited by 250 · see citing works

α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

Manning-Bog, A., McCormack, A. L., Purisai, M. G., Bolin, L. M., & Monte, D. A. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03095.2003 · Cited by 239 · see citing works

Calcium homeostasis, selective vulnerability and Parkinson's disease

Chan, C. S., Gertler, T. S., & Surmeier, D. J. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.006 · Cited by 239 · see citing works

Pesticide/Environmental Exposures and Parkinson's Disease in East Texas

Dhillon, A. S., Tarbutton, G. L., Levin, J. L., Plotkin, G. M., Lowry, L. K., Nalbone, J. T., & Shepherd, S. (2008) · Journal of Agromedicine · doi:10.1080/10599240801986215 · Cited by 238 · see citing works

Biochemical and pathological characterization of Lrrk2

Giasson, B. I., Covy, J. P., Bonini, N. M., Hurtig, H. I., Farrer, M. J., Trojanowski, J. Q., & Deerlin, V. M. V. (2006) · Annals of Neurology · doi:10.1002/ana.20791 · Cited by 238 · see citing works

Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain

Lee, S., Kim, S. J., Kim, I.-K., Ko, J., Jeong, C., Kim, G.-H., Park, C., Kang, S.-O., Suh, P., Lee, H.-S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304517200 · Cited by 236 · see citing works

Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease

McNaught, K. S. P., Belizaire, R., Jenner, P. G., Olanow, C. W., & Ole Isacson, A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00296-3 · Cited by 234 · see citing works

Pesticides and Risk of Parkinson Disease

Firestone, J. A., Smith‐Weller, T., Franklin, G. M., Swanson, P. D., Longstreth, W. T., Jr., & Checkoway, H. (2005) · Archives of Neurology · doi:10.1001/archneur.62.1.91 · Cited by 232 · see citing works

Dopamine uptake: A review of progress in the last decade

Horn, A. S. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90033-d · Cited by 230 · see citing works

Absence of MPTP-Induced Neuronal Death in Mice Lacking the Dopamine Transporter

Bézard, E., Gross, C. E., Fournier, M.-C., Doveró, S., Bloch, B., & Jaber, M. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.6995 · Cited by 227 · see citing works

The Impact of the E46K Mutation on the Properties of α-Synuclein in Its Monomeric and Oligomeric States

Fredenburg, R. A., Rospigliosi, C. C., Meray, R. K., Kessler, J. C., Lashuel, H. A., Eliezer, D., & Lansbury, P. T. (2007) · Biochemistry · doi:10.1021/bi7000246 · Cited by 227 · see citing works

Any way you cut it: A new journal policy for the use of unbiased counting methods

Saper, C. B. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960101)364:1 · Cited by 226 · see citing works

The discovery of dopamine deficiency in the parkinsonian brain

Hornykiewicz, O. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_3 · Cited by 219 · see citing works

Ubiquitin–proteasome system and Parkinson's disease

Olanow, C. W., & McNaught, K. S. P. (2006) · Movement Disorders · doi:10.1002/mds.21013 · Cited by 213 · see citing works

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

Rodríguez‐Pallares, J., Rey, P., Parga, J. A., Muñoz, A., Guerra, M. J., & Labandeira-García, J. L. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.03.003 · Cited by 212 · see citing works

Possible role of neuromelanin in the pathogenesis of Parkinson's disease

Mann, D. M. A., & Yates, P. O. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90074-x · Cited by 211 · see citing works

Lewy Body-Related α-Synucleinopathy in Aging

Saito, Y., Ruberu, N. N., Sawabe, M., Arai, T., Kazama, H., Hosoi, T., Yamanouchi, H., & Murayama, S. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.742 · Cited by 200 · see citing works

The role of α-synuclein in neurodegenerative diseases

Bennett, M. C. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.010 · Cited by 195 · see citing works

Marked disparity between age‐related changes in dopamine and other presynaptic dopaminergic markers in human striatum

Haycock, J. W., Becker, L. E., Ang, L. C., Furukawa, Y., Hornykiewicz, O., & Kish, S. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02017.x · Cited by 195 · see citing works

Interactions Among α-Synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson's Disease

Rochet, J., Outeiro, T. F., Conway, K. A., Ding, T. T., Volles, M. J., Lashuel, H. A., Bieganski, R. M., Lindquist, S. L., & Lansbury, P. T. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:023 · Cited by 191 · see citing works

The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease

Joglar, B., Rodríguez‐Pallares, J., Rodriguez-Perez, A. I., Rey, P., Guerra, M. J., & Labandeira-García, J. L. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05999.x · Cited by 190 · see citing works

Apoptotic mechanisms in mutant LRRK2-mediated cell death

Iaccarino, C., Crosio, C., Vitale, C., Sanna, G., Carrı̀, M. T., & Barone, P. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm080 · Cited by 190 · see citing works

Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: Comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity

Haber, S. N., Ryoo, H., Cox, C., & Lu, W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903620308 · Cited by 188 · see citing works

Rotenone induces non‐specific central nervous system and systemic toxicity

Lapointe, N. P., St‐Hilaire, M., Martinoli, M., Blanchet, J., Gould, P. V., Rouillard, C., & Cicchetti, F. (2004) · The FASEB Journal · doi:10.1096/fj.03-0677fje · Cited by 187 · see citing works

Quantitation of Fluorescence of Biogenic Monoamines

JONSSON, G. (1971) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(71)80001-3 · Cited by 183 · see citing works

Role of voltage-gated L-type Ca2+ channel isoforms for brain function

Striessnig, J., Koschak, A., Sinnegger-Brauns, M. J., Hetzenauer, A., Nguyen, N. K., Busquet, P., Pelster, G., & Singewald, N. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340903 · Cited by 183 · see citing works

Acute and Repeated Systemic Amphetamine Administration: Effects on Extracellular Glutamate, Aspartate, and Serine Levels in Rat Ventral Tegmental Area and Nucleus Accumbens

Xue, C., Ng, J. P., Li, Y., & Wolf, M. E. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67010352.x · Cited by 177 · see citing works

Cloned Glutamate Receptors

Hollmann, M. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.17.1.31 · Cited by 177 · see citing works

Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat

Forster, G. L., & Blaha, C. D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02511.x · Cited by 175 · see citing works

Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism

Greene, J. G., Dingledine, R. J., & Greenamyre, J. T. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.003 · Cited by 174 · see citing works

Tonic release of glutamate by a DIDS‐sensitive mechanism in rat hippocampal slices

Cavelier, P., & Attwell, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.082131 · Cited by 166 · see citing works

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

Monte, D. A. D., Jewell, S. A., Ekström, G., Sandy, M. S., & Smith, M. T. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)91211-8 · Cited by 166 · see citing works

Mitochondrial associated metabolic proteins are selectively oxidized in A30P α-synuclein transgenic mice—a model of familial Parkinson's disease

Poon, H. F., Frasier, M. A., Shreve, N., Calabrese, V., Wolozin, B. L., & Butterfield, D. A. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.009 · Cited by 165 · see citing works

Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

Hosoi, T., & Ozawa, K. (2009) · Clinical Science · doi:10.1042/cs20080680 · Cited by 164 · see citing works

Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism

Collier, T. J., Lipton, J., Daley, B. F., Palfi, S., Chu, Y., Sortwell, C., Bakay, R. A. E., Sladek, J. R., & Kordower, J. H. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.013 · Cited by 162 · see citing works

Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

Nishikawa, K., Li, H., Kawamura, R., Osaka, H., Wang, Y.-L., Hara, Y., Hirokawa, T., Manago, Y., Amano, T., Noda, M., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00555-2 · Cited by 159 · see citing works

Preservation of midbrain catecholaminergic neurons in very old human subjects

Kubis, N., Faucheux, B. A., Ransmayr, G. N., Damier, P., Duyckaerts, C. J., Hénin, D., Forette, B., Charpentier, Y. L., Hauw, J., Agid, Y., et al. (2000) · Brain · doi:10.1093/brain/123.2.366 · Cited by 157 · see citing works

Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species

Fornstedt, B., Rosengren, E., & Carlsson, A. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90242-x · Cited by 155 · see citing works

Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease

Gibb, W. R. G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90719-p · Cited by 152 · see citing works

Differences in Dopamine Clearance and Diffusion in Rat Striatum and Nucleus Accumbens Following Systemic Cocaine Administration

Cass, W. A., Gerhardt, G. A., Mayfield, R. D., Curella, P., & Zahniser, N. R. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08899.x · Cited by 152 · see citing works

Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons

Uhl, G. R., Walther, D. M., Mash, D. C., Faucheux, B. A., & Javoy-Agid, F. (1994) · Annals of Neurology · doi:10.1002/ana.410350421 · Cited by 151 · see citing works

Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy

Cabello, C. R., Thune, J. J., Pakkenberg, H., & Pakkenberg, B. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00393.x · Cited by 150 · see citing works

Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms

Bézard, E., Boraud, T., Bioulac, B. H., & Gross, C. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00627.x · Cited by 146 · see citing works

Pael‐R is accumulated in Lewy bodies of Parkinson's disease

Murakami, T., Shoji, M., Imai, Y., Inoue, H., Kawarabayashi, T., Matsubara, E., Harigaya, Y., Sasaki, A., Takahashi, R., & Abe, K. (2004) · Annals of Neurology · doi:10.1002/ana.20064 · Cited by 146 · see citing works

Parkinson’s Disease

Mhyre, T. R., Boyd, J. T., Hamill, R. W., & Maguire‐Zeiss, K. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_16 · Cited by 442 · see citing works

Local cues establish and maintain region-specific phenotypes of basal ganglia microglia

De Biase, L. M., Schuebel, K. E., Fusfeld, Z. H., Jair, K., Hawes, I. A., Cimbro, R., Zhang, H.-Y., Liu, Q.-R., Shen, H., Xi, Z.-X., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.020 · Cited by 432 · see citing works

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

Moehle, M. S., & West, A. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.018 · Cited by 198 · see citing works

Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease

Duda, J., Pötschke, C., & Liss, B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13572 · Cited by 149 · see citing works

Cannabidiol as a Therapeutic Target: Evidence of its Neuroprotective and Neuromodulatory Function in Parkinson’s Disease

Patricio, F., Morales-Andrade, A. A., Patricio-Martínez, A., & Limón, I. D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.595635 · Cited by 129 · see citing works

l-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?

Lipski, J., Nisticò, R., Berretta, N., Guatteo, E., Bernardi, G., & Mercuri, N. B. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.005 · Cited by 116 · see citing works

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

Hoban, D. B., Connaughton, E., Connaughton, C., Hogan, G., Thornton, C., Mulcahy, P. J., Moloney, T. C., & Dowd, E. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.001 · Cited by 113 · see citing works

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

Tosatto, L., Horrocks, M. H., Dear, A. J., Knowles, T. P. J., Serra, M. D., Cremades, N., Dobson, C. M., & Klenerman, D. (2015) · Scientific Reports · doi:10.1038/srep16696 · Cited by 110 · see citing works

Involvement of microglial RhoA/Rho-kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

Villar-Cheda, B., Dominguez-Meijide, A., Joglar, B., Rodriguez-Perez, A. I., Guerra, M. J., & Labandeira-Garcia, J. L. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.010 · Cited by 104 · see citing works

Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin–angiotensin system in the nigra

Garrido‐Gil, P., Valenzuela, R., Villar‐Cheda, B., Lanciego, J. L., & Labandeira-García, J. L. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0402-9 · Cited by 107 · see citing works

Interaction between NADPH ‐oxidase and R ho‐kinase in angiotensin II ‐induced microglial activation

Rodriguez-Perez, A. I., Borrajo, A., Rodríguez‐Pallares, J., Guerra, M. J., & Labandeira-García, J. L. (2014) · Glia · doi:10.1002/glia.22765 · Cited by 96 · see citing works

Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats

Cai, X., Qiao, J., Kulkarni, P. P., Harding, I. C., Ebong, E. E., & Ferris, C. F. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914017117 · Cited by 86 · see citing works

LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease

Lee, H., James, W., & Cowley, S. A. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160262 · Cited by 82 · see citing works

Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

Borrajo, A., Rodriguez-Perez, A. I., Villar-Cheda, B., Guerra, M. J., & Labandeira-Garcia, J. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.021 · Cited by 75 · see citing works

Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways

Krabbendam, I. E., Honrath, B., Culmsee, C., & Dolga, A. M. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.07.005 · Cited by 73 · see citing works

Particulate matter neurotoxicity in culture is size-dependent

Gillespie, P. A., Tajuba, J., Lippmann, M., Chen, L., & Veronesi, B. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.10.006 · Cited by 68 · see citing works

RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson’s disease

Dutta, D., Kundu, M., Mondal, S., Roy, A., Ruehl, S., Hall, D. A., & Pahan, K. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104575 · Cited by 51 · see citing works

Omega-3 Deficiency and Neurodegeneration in the Substantia Nigra: Involvement of Increased Nitric Oxide Production and Reduced BDNF Expression

Cardoso, H. D., Santos Junior, E. F. D., de Santana, D. F., Gonçalves-Pimentel, C., Angelim, M. K., Isaac, A. R., Lagranha, C. J., Guedes, R. C. A., Beltrão, E. I., Morya, E., et al. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.12.023 · Cited by 55 · see citing works

Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra

Bifsha, P., Yang, J., Fisher, R. A., & Drouin, J. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004863 · Cited by 54 · see citing works

Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson’s Disease

Labandeira-Garcia, J. L., Rodríguez-Perez, A. I., Villar-Cheda, B., Borrajo, A., Dominguez-Meijide, A., & Guerra, M. J. (2015) · The Neuroscientist · doi:10.1177/1073858414554954 · Cited by 54 · see citing works

RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer

Ahlers‐Dannen, K. E., Chakravarti, B., & Fisher, R. A. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9899-9 · Cited by 40 · see citing works

Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat

Ambrosi, G., Kuštrimović, N. Z., Siani, F., Rasini, E., Cerri, S., Ghezzi, C., Dicorato, G., Caputo, S., Marino, F., Cosentino, M., et al. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9712-2 · Cited by 41 · see citing works

Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease

Brazdis, R.-M., Alecu, J. E., Marsch, D., Dahms, A., Simmnacher, K., Lörentz, S., Brendler, A., Schneider, Y., Marxreiter, F., Roybon, L., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa039 · Cited by 37 · see citing works

Renin angiotensin system and gender differences in dopaminergic degeneration

Rodriguez-Perez, A. I., Valenzuela, R., Joglar, B., Garrido‐Gil, P., Guerra, M. J., & Labandeira-García, J. L. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-58 · Cited by 38 · see citing works

Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice

Luo, Z., Ahlers‐Dannen, K. E., Spicer, M. M., Yang, J., Alberico, S. L., Stevens, H. E., Narayanan, N. S., & Fisher, R. A. (2019) · JCI Insight · doi:10.1172/jci.insight.126769 · Cited by 29 · see citing works

Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson’s disease, with insights into Pink1 knockout models

Wang, Z., Chan, S.-W., Zhao, H., Miu, K.-K., & Chan, W. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.406 · Cited by 28 · see citing works

Features and timing of the response of single neurons to novelty in the substantia nigra

Mikell, C. B., Sheehy, J. P., Youngerman, B. E., McGovern, R. A., Wojtasiewicz, T. J., Chan, A. K.-H., Pullman, S. L., Yu, Q. P., Goodman, R. R., Schevon, C. A., et al. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.033 · Cited by 27 · see citing works

Differential expression of calbindin in nigral dopaminergic neurons in two mice strains with differential susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Vidyadhara, D. J., Yarreiphang, H., Abhilash, P. L., Raju, T. R., & Alladi, P. A. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.01.001 · Cited by 22 · see citing works

Laser capture microdissection protocol for gene expression analysis in the brain

Garrido‐Gil, P., Fernandez‐Rodriguez, P., Rodríguez‐Pallares, J., & Labandeira-García, J. L. (2017) · Histochemistry and Cell Biology · doi:10.1007/s00418-017-1585-1 · Cited by 21 · see citing works

4R-Cembranoid Improves Outcomes after 6-Hydroxydopamine Challenge in Both In vitro and In vivo Models of Parkinson's Disease

Hu, J., Ferchmin, P. A., Hemmerle, A. M., Seroogy, K. B., Eterović, V. A., & Hao, J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00272 · Cited by 21 · see citing works

Admixing MPTP-resistant and MPTP-vulnerable mice enhances striatal field potentials and calbindin-D28K expression to avert motor behaviour deficits

Vidyadhara, D. J., Sasidharan, A., Kutty, B. M., Raju, T. R., & Alladi, P. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.015 · Cited by 16 · see citing works

Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons

Bifsha, P., Balsalobre, A., & Drouin, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0040-y · Cited by 16 · see citing works

Mutations and Binding Sites of Human Transcription Factors

Kamanu, F., Medvedeva, Y. A., Schaefer, U., Janković, B. R., Archer, J. A. C., & Bajić, V. B. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00100 · Cited by 16 · see citing works

The cellular and genomic response of rat dopaminergic neurons (N27) to coated nanosilver

Chorley, B. N., Ward, W. O., Simmons, S. O., Vallanat, B., & Veronesi, B. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.08.010 · Cited by 16 · see citing works

Effects of Global Warming on Patients with Dementia, Motor Neuron or Parkinson’s Diseases: A Comparison among Cortical and Subcortical Disorders

Bongioanni, P., Carratore, R. D., Dolciotti, C., Diana, A., & Buizza, R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192013429 · Cited by 14 · see citing works

Nanoformulation: A Useful Therapeutic Strategy for Improving Neuroprotection and the Neurorestorative Potential in Experimental Models of Parkinson's Disease

Lafuente, J. V., Requejo, C., Carrasco, A., & Bengoetxea, H. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.09.003 · Cited by 14 · see citing works

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons in rats associated with the increased endophilin A2 expression

Xue, H.-X., Kong, H., Yu, Y.-G., Zhou, J., Chen, H.-Q., & Yin, Y. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000515 · Cited by 14 · see citing works

Short- and long-term effects induced by repeated 6-OHDA intraventricular administration: A new progressive and bilateral rodent model of Parkinson’s disease

Quiroga‐Varela, A., Aguilar, E., Iglesias, E., Obeso, J. A., & Marı́n, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.017 · Cited by 14 · see citing works

Does MPTP intoxication in mice induce metabolite changes in the nucleus accumbens? A 1H nuclear MRS study

Chassain, C., Biélicki, G., Carcenac, C., Ronsin, A.-C., Renou, J., Savasta, M., & Durif, F. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2853 · Cited by 12 · see citing works

Effects of particulate matter and nicotine for the MPP+-induced SH-SY5Y cells: Implication for Parkinson’s disease

Jung, Y. J., Choi, H., & Oh, E. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136265 · Cited by 12 · see citing works

Behavioral Deficits and Brain α-Synuclein and Phosphorylated Serine-129 α-Synuclein in Male and Female Mice Overexpressing Human α-Synuclein

Gabrielyan, L., Liang, H., Minalyan, A., Hatami, A., John, V., & Wang, L. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200983 · Cited by 12 · see citing works

Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon

Jaumotte, J. D., Saarma, M., & Zigmond, M. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245663 · Cited by 10 · see citing works

Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra

Burkert, N., Roy, S., Häusler, M., Wuttke, D., Müller, S., Wiemer, J., Hollmann, H., Oldrati, M., Ramírez‐Franco, J., Benkert, J., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05441-6 · Cited by 9 · see citing works

Mating-relevant olfactory stimuli activate the rat brain in an age-dependent manner

Tobiansky, D. J., Hattori, T., Scott, J. M., Nutsch, V. L., Roma, P. G., & Dominguez, J. M. (2012) · Neuroreport · doi:10.1097/wnr.0b013e32835b6ec1 · Cited by 9 · see citing works

Morphological Changes in a Severe Model of Parkinson’s Disease and Its Suitability to Test the Therapeutic Effects of Microencapsulated Neurotrophic Factors

Requejo, C., Ruíz-Ortega, J. Á., Bengoetxea, H., García-Blanco, A., Herrán, E., Aristieta, A., Igartúa, M., Pedraz, J. L., Ugedo, L., Hernández, R. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0244-1 · Cited by 8 · see citing works

Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease

Ray, A., Kambali, M., & Ravindranath, V. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6602 · Cited by 6 · see citing works

hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation

Weidling, I. W., Preiss, C. N., Chancellor, S. E., Srivastava, G. P., Gibilisco, L., Lin, G., Brennan, M. S., Lee, J. Y., Roth, L. M., Morozova, O., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02000-4 · Cited by 5 · see citing works

Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinson’s Disease

Drion, G., Seutin, V., & Sepulchre, R. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3411-5_4 · Cited by 5 · see citing works

Four main therapeutic keys for Parkinson's disease: A mini review.

Hernández-Baltazar, D., Nadella, R., Zavala-Flores, L. M., Rosas-Jarquín, C. D. J., Rovirosa-Hernández, M. D. J., & Villanueva-Olivo, A. (2019) · PubMed Central · doi:10.22038/ijbms.2019.33659.8025 · Cited by 5 · see citing works

Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum.

Huang, Y. M., Chang, C.-Y., Zhang, J., & Gao, X. (2012) · PubMed Central · doi:10.3969/j.issn.1673-5374.2012.34.002 · Cited by 5 · see citing works

Energy metabolic failure drives the selective degeneration of dopaminergic neurons in Parkinson’s disease

Zhou, Z. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111722 · Cited by 3 · see citing works

Basal Ganglia Circuits: What's Now and Next?

Lanciego, J. L. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00004 · Cited by 3 · see citing works

TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons

Kwon, H. J., Jung, H. Y., Choi, S. Y., Hwang, I. K., Kim, D. W., & Shin, M. J. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103978 · Cited by 2 · see citing works

FRET-based assays for neurological disease and diagnostics

Aich, J., Singh, S., Chandrashekhar, S., Srivastav, V., Devarajan, S., & Basu, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95539-3.00005-3 · Cited by 1 · see citing works

ELECTRONIC ANALOGY TO SIMULATE AND PREDICT THE DYNAMICS OF CELLULAR MECHANISM OF PARKINSON’S DISEASE STIMULATED BY ENVIRONMENTAL FACTORS

Chaudhary, N., Aggarwal, Y., Singh, N., & Sinha, R. K. (2015) · Biomedical Engineering Applications Basis and Communications · doi:10.4015/s1016237215500519

Electronic Simulation of Neuronal Degeneration in Parkinson Disease

Chaudhary, N., Aggarwal, Y., & Sinha, R. K. (2015) · Journal of Clinical Engineering · doi:10.1097/jce.0000000000000092

Substantia Nigra Modulation by Essential Fatty Acids

Andrade‐da‐Costa, B. L. D. S., Passos, P. P., Cardoso, H. D., Gonçalves‐Pimentel, C., dos Santos, E. F., Borba, J. M. C., & Guedes, R. C. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00020-x

Inhibition of Brain CYP2D Lowers Codeine-induced Analgesia in Rats

Zhou, K. (2012) · TSpace (University of Toronto)

The application of multimodal MRI in the identification of neurological biomarkers for Parkinson's disease and the investigation of the role of glymphatic system in the development of Parkinsonism

Cai, X. (2020) · doi:10.17760/d20398331

Faculty Opinions recommendation of Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

Gould, E. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727795770.793537494

Age and IFN-gamma deficiency modulate the impact of repeated paraquat exposure in a mouse model of Parkinson's disease

Moloney, K. (2011) · doi:10.22215/etd/2011-07061

Annonacin in Asimina triloba fruit : implications for neurotoxicity.

Potts, L. (2011) · doi:10.18297/etd/1145

Role of glutamate N-Methyl-D-Aspartate receptor surface trafficking in the firing pattern of midbrain dopaminergic neurons

Etchepare, L. (2017) · theses.fr (ABES) · doi:10.70675/21d34163z8300z423ez9dd5zda877d3a577a

SHH mediated human dopaminergic neuron differentiation is facilitated by transcription factor ZIC3

Sheshadri, P., Bhaskar, S., Gowda, J., Banerjee, S., Duchen, M. R., Prasanna, J., & Kumar, A. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2026.120213

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

Brichta, L., & Greengard, P. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00152 · Cited by 214 · see citing works

Neuronal vulnerability in Parkinson’s disease

Hirsch, É. C., Faucheux, B. A., Damier, P., Prigent, A., & Agid, Y. (1997) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6842-4_9 · Cited by 192 · see citing works

Phenotype, Compartmental Organization and Differential Vulnerability of Nigral Dopaminergic Neurons

González‐Hernández, T., Afonso‐Oramas, D., & Cruz‐Muros, I. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_2 · Cited by 13 · see citing works

Biochemistry of Parkinson's disease with special reference to the dopaminergic systems

Hirsch, É. C. (1994) · Molecular Neurobiology · doi:10.1007/bf02816113 · Cited by 80 · see citing works

Developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration

Prakash, N. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1071731 · Cited by 13 · see citing works