Cited by 266Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

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Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease

Reiman, Eric M., Uecker, Anne, Caselli, Richard J., Lewis, Stephen, Bandy, Daniel, De Leon, Mony J., De Santi, Susan, Convit, Antonio, Osborne, David, Weaver, Amy, Thibodeau, Stephen N.·1998·Annals of Neurology

DOI 10.1002/ana.410440226

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Abstract

Brain imaging techniques have the potential to characterize neurobiological changes that precede the onset of cognitive impairment in persons at risk for Alzheimer's disease. As previously described, positron emission tomography (PET) was used to compare 11 cognitively normal persons 50 to 62 years of age who were homozygous for the ε4 allele of apolipoprotein E and 22 persons without the ε4 allele with a reported family history of Alzheimer's dementia who were matched for sex, age, and level of education. The ε4 homozygotes had significantly reduced glucose metabolism in the same brain regions as patients with Alzheimer's dementia; the largest reduction was in the posterior cingulate cortex. As described here, magnetic resonance imaging (MRI) was used to compare hippocampal volumes in the same subject groups. The ε4 homozygotes showed nonsignificant trends for smaller left and right hippocampal volumes; overall, smaller hippocampal volumes were associated with reduced performance on a long‐term memory test. Whereas PET measurements of cerebral glucose metabolism begin to decrease before the onset of memory decline, MRI measurements of hippocampal volume begin to decrease in conjunction with memory decline in cognitively normal persons at risk for Alzheimer's disease.

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Authors: Reiman, E. M., Uecker, A., Caselli, R. J., Lewis, S., Bandy, D., De Leon, M. J., De Santi, S., Convit, A., Osborne, D., Weaver, A., & Thibodeau, S. N.
Affiliations: University of Arizona (US)
Mayo Clinic (US)
Good Samaritan Regional Medical Center (US)
NYU Langone Health (US)
Corresponding author: Reiman, Eric M.
ORCID: Reiman, Eric M.
Caselli, Richard J.
Lewis, Stephen
Convit, Antonio
Weaver, Amy
Thibodeau, Stephen N.
Venue: Annals of Neurology
Publisher: Wiley
Published: 1998-08
Volume: 44
Issue: 2
Pages: 288-291
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.410440226
OpenAlex: W1996433268
Cited by: 266
References: 19
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 14 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 15 · 2013: 7 · 2012: 13
FWCI: 9.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2260 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 12101, R01AG013616, AG 13616)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: hippocampal volume, Alzheimer's disease, APOE ε4, genetic risk, cognitively normal elderly, family history of dementia, brain glucose metabolism, posterior cingulate cortex, long-term memory, hippocampal atrophy, early detection of cognitive decline
MeSH terms: Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Carrier State, Genotype, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Middle Aged, Neuropsychological Tests, Reference Values, Sensitivity and Specificity, Chi-Square Distribution, Logistic Models

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Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease

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