Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals
Open accessAbstract
Alzheimer’s disease (AD) is the most common form of dementia in old age, and is characterized by prominent impairment of episodic memory. Recent functional imaging studies in AD have demonstrated alterations in a distributed network of brain regions supporting memory function, including regions of the default mode network. Previous positron emission tomography studies of older individuals at risk for AD have revealed hypometabolism of association cortical regions similar to the metabolic abnormalities seen in AD patients. In recent functional magnetic resonance imaging (fMRI) studies of AD, corresponding brain default mode regions have also been found to demonstrate an abnormal fMRI task-induced deactivation response pattern. That is, the relative decreases in fMRI signal normally observed in the default mode regions in healthy subjects performing a cognitive task are not seen in AD patients, or may even be reversed to a paradoxical activation response. Our recent studies have revealed alterations in the pattern of deactivation also in elderly individuals at risk for AD by virtue of their APOE e4 genotype, or evidence of mild cognitive impairment (MCI). In agreement with recent reports from other groups, these studies demonstrate that the pattern of fMRI task-induced deactivation is progressively disrupted along the continuum from normal aging to MCI and to clinical AD and more impaired in e4 carriers compared to non-carriers. These findings will be discussed in the context of current literature regarding functional imaging of the default network in AD and at-risk populations.
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Cognitively normal apoE4 carriers show reduced task-induced deactivation of the default mode network (DMN).
“First, cognitively normal apoE4 carriers show reduced task-induced deactivation of the default mode network (DMN) [162–164].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [164]
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- Authors
- Pihlajamäki, M., & Sperling, R. A.
- Affiliations
- Memory Disorders Unit, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Brigham and Women's Hospital (US)
- ORCID
- Sperling, Reisa A.
- Venue
- Behavioural Neurology
- Publisher
- Wiley
- Published
- 2009
- Volume
- 21
- Issue
- 1-2
- Pages
- 77-91
- ISSN
- 0953-4180 (ISSN-L)
- 1875-8584
- PMC
- PMC5450588
- OpenAlex
- W4243607498
- Cited by
- 102
- References
- 82
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 10
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Behavioural Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubMed
- Funders
- National Institute on Aging (R01 AG027435, PO1-AG04953, P50-AG00513421, 108188, 214050, K23-NS02189)
- Academy of Finland (R01 AG027435, PO1-AG04953, P50-AG00513421, 108188, 214050, K23-NS02189)
- National Institute of Neurological Disorders and Stroke (R01 AG027435, PO1-AG04953, P50-AG00513421, 108188, 214050, K23-NS02189)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, default mode network, task-induced deactivation, APOE ε4, mild cognitive impairment, normal aging, episodic memory, brain hypometabolism, paradoxical activation, vulnerable elderly
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Brain, Brain Mapping, Cognition Disorders, Female, Genotype, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Nerve Net, Neuropsychological Tests, Signal Processing, Computer-Assisted, Patient Selection, Genetic Predisposition to Disease
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