Chemical primer extension: efficiently determining single nucleotides in DNA

DNA sequencing with chain-terminating inhibitors

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Epigenetics in human disease and prospects for epigenetic therapy

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1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive

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Prebiotic chemistry and the origin of the RNA world.

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Chip-based genotyping by mass spectrometry.

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Prebiotic chemistry and nucleic acid replication

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Surface-promoted replication and exponential amplification of DNA analogues

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Nonenzymatic synthesis of oligoadenylates on a polyuridylic acid template.

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Genotyping single nucleotide polymorphisms by mass spectrometry

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Substituent control of the poly(C)-directed oligomerization of guanosine 5'-phosphoroimidazolide

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Synthesis of 35–40 mers of RNA oligomers from unblocked monomers. A simple approach to the RNA world

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Nonenzymic template-directed synthesis on oligodeoxycytidylate sequences in hairpin oligonucleotides

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Nonenzymatic template-directed synthesis on hairpin oligonucleotides. 3. Incorporation of adenosine and uridine residues.

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Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes

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The Polymerase Chain Reaction (Nobel Lecture)

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Quantitative MALDI-TOF MS of oligonucleotides and a nuclease assay

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Adenine Derivatives as Phosphate-Activating Groups for the Regioselective Formation of 3‘,5‘-Linked Oligoadenylates on Montmorillonite: Possible Phosphate-Activating Groups for the Prebiotic Synthesis of RNA

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Enzymatic Behavior by Intercalating Molecules in a Template‐Directed Ligation Reaction

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Effect of Phosphate Activating Group on Oligonucleotide Formation on Montmorillonite: The Regioselective Formation of 3',5'-Linked Oligoadenylates

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A steroid cap adjusts the selectivity and accelerates the rates of nonenzymatic single nucleotide extensions of an oligonucleotide

Rojas Stütz, J. A., & Richert, C. (2001) · Journal of the American Chemical Society · doi:10.1021/ja011448i · Cited by 30 · see citing works

Die Polymerase‐Kettenreaktion (Nobel‐Vortrag)

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A Direct Glimpse of Cross‐Hybridization: Background‐Passified Microarrays That Allow Mass‐Spectrometric Detection of Captured Oligonucleotides

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Nonenzymatic Oligomerization of Ribonucleotides: Towards in vitro Selection Experiments

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A Direct Glimpse of Cross‐Hybridization: Background‐Passified Microarrays That Allow Mass‐Spectrometric Detection of Captured Oligonucleotides

Plutowski, U., & Richert, C. (2004) · Angewandte Chemie · doi:10.1002/ange.200461212 · Cited by 18 · see citing works

Large Steric Effect in the Substitution Reaction of Amines with Phosphoimidazolide-Activated Nucleosides

Kanavarioti, A., Stronach, M. W., Ketner, R. J., & Hurley, T. B. (1995) · The Journal of Organic Chemistry · doi:10.1021/jo00108a027 · Cited by 17 · see citing works

Enzymatic Behavior by Intercalating Molecules in a Template‐Directed Ligation Reaction

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Acceleration of the template-directed reactions of nucleoside 5′-phosphorimidazolides by acylation

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Template-directed synthesis of a genetic polymer in a model protocell

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Origins of building blocks of life: A review

Kitadai, N., & Maruyama, S. (2018) · Geoscience Frontiers · doi:10.1016/j.gsf.2017.07.007 · Cited by 464 · see citing works

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

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Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication

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Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers

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The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA

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Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences

Leu, K., Kervio, E., Obermayer, B., Turk-MacLeod, R. M., Yuan, C., Luevano, J.-M., Chen, E., Gerland, U., Richert, C., & Chen, I. A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja3095558 · Cited by 78 · see citing works

Copying of RNA Sequences without Pre‐Activation

Jauker, M., Griesser, H., & Richert, C. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506592 · Cited by 72 · see citing works

Templating efficiency of naked DNA

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Enzyme-free genetic copying of DNA and RNA sequences

Sosson, M., & Richert, C. (2018) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.14.47 · Cited by 33 · see citing works

Chemical primer extension: Individual steps of spontaneous replication

Stütz, J. A. R., Kervio, E., Deck, C., & Richert, C. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790064 · Cited by 30 · see citing works

Adenosine residues in the template do not block spontaneous replication steps of RNA

Vogel, S. R., & Richert, C. (2007) · Chemical Communications · doi:10.1039/b702768k · Cited by 28 · see citing works

Tuning the reaction site for enzyme-free primer-extension reactions through small molecule substituents

Rojas Stütz, J. A., & Richert, C. (2006) · Chemistry – A European Journal · doi:10.1002/chem.200501008 · Cited by 9 · see citing works

Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis

Joshi, S., Romanens, P., & Winssinger, N. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c00708 · Cited by 4 · see citing works

Pair Formation of Free Nucleobases and Mononucleosides in the Gas Phase

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Unexpectedly Small Effect of the DNA Environment on Vertical Ionization Energies of Aqueous Nucleobases

Pluhařová, E., Schroeder, C., Seidel, R. W., et al. (2013) · The Journal of Physical Chemistry Letters · doi:10.1021/jz402106h · Cited by 41 · see citing works

Analysis of nucleotides, nucleosides, nucleobases in cells by ion-pair reversed-phase HPLC

Werner, A. (1991) · Chromatographia · doi:10.1007/bf02262200 · Cited by 17 · see citing works

Primer Extension Methods for Determination of β1-Adrenergic Receptor mRNA Start Sites

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Constraints on the Emergence of RNA through Non-Templated Primer Extension with Mixtures of Potentially Prebiotic Nucleotides

(2024) · doi:10.1101/2024.01.21.576316