Substituent control of the poly(C)-directed oligomerization of guanosine 5'-phosphoroimidazolide
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent control of the poly(C)-directed oligomerization of guanosine 5'-phosphoroimidazolideTan Inoue and Leslie E. OrgelCite this: J. Am. Chem. Soc. 1981, 103, 25, 7666–7667Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/ja00415a051https://doi.org/10.1021/ja00415a051research-articleACS PublicationsRequest reuse permissionsArticle Views574Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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2-methylimidazole (2MeI) is an especially good nucleotide activating agent.
“Since the discovery in 1981 that 2-methylimidazole (2MeI) is an especially good nucleotide activating agent”
From Protocells and RNA Self-Replication (2018) · cites this paper as Inoue and Orgel 1981
Extensive optimization of reaction conditions improved the rate and regiospecificity of polymerization for G and C but not A and U.
“Extensive optimization of reaction conditions with the aim of improving the rate of primer extension with all four monomers, including varying the choice of divalent cation and leaving group, improved the rate and regiospecificity of polymerization for G and C but not A and U (Wu and Orgel, 1992b, c; Deck et al., 2011; Inoue and Orgel, 1981; Hagenbuch et al., 2005; Lohrmann et al., 1980).”
From Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides (2016) · cites this paper as Inoue and Orgel, 1981
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- Authors
- Inoue, T., & Orgel, L. E.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1981-12
- Volume
- 103
- Issue
- 25
- Pages
- 7666-7667
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2064064572
- Cited by
- 120
- References
- 0
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 5 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Keywords
- oligomerization, substituent effects, nucleotide analogues, nucleic acid synthesis
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