Alzheimer's Disease: From Pathology to Therapeutic Approaches

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Inflammation and Alzheimer’s disease

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer’s Disease: In Vivo, In Vitro, Histopathological, and Docking Studies

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Structural Basis of β‐Amyloid‐Dependent Synaptic Dysfunctions

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Proteolytically Stable ααγ-Hybrid Peptides Inhibit the Aggregation and Cytotoxicity of Aβ42

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Diosmetin derivatives as multifunctional anti‐AD ligands: Design, synthesis, and biological evaluation

Yang, A., Yi, X., Zhang, H., Shen, R., & Kou, X. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14529 · Cited by 7

Theoretical studies on the spectroscopic properties of a series of halide Zinc (II) complexes with pyridinylimine and pyridinylmethylamine derivatives

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Repurposing FDA‐Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease

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Multi‐Targeting Tacrine Conjugates with Cholinesterase and Amyloid‐Beta Inhibitory Activities: New Anti‐Alzheimer's Agents

Hiremathad, A., Chaves, S., & Keri, R. S. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202000083 · Cited by 7

Controlled release of Clenbuterol from a hydroxyapatite carrier for the treatment of Alzheimer’s Disease

Lin, Y., Fang, C.-H., Liang, Y., Yang, C.-Y., Kuo, W., & Lin, F. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00432-4 · Cited by 7

Associations Between Intrathecal Levels of Vitamin D, Cytokines, and Core Biomarkers of Alzheimer’s Disease: A Cross-Sectional Study

Soares, J. Z., Valeur, J., Benth, J. Š., Knapskog, A., Selbæk, G., Bogdanović, N., & Pettersen, R. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220407 · Cited by 8

A small bifunctional chelator that modulates Aβ42 aggregation

Zhang, C., Gomes, L. M., Zhang, T., & Storr, T. (2017) · Canadian Journal of Chemistry · doi:10.1139/cjc-2017-0623 · Cited by 7

Tetrahedral DNA-modified quantum dot nanobeads for highly sensitive fluorescent detection of amyloid-β oligomers in blood serum

Hu, O., Gong, Y., Li, Z., Xie, X., Xu, D., Bi, W., & Jiang, Z. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167446 · Cited by 6

A novel selective phosphodiesterase 9 inhibitor, irsenontrine (E2027), enhances GluA1 phosphorylation in neurons and improves learning and memory via cyclic GMP elevation

Ishihara, Y., Ando, M., Goto, Y., Kotani, S., Watanabe, N., Nakatani, Y., Ishii, S., Miyamoto, N., Mano, Y., & Ishikawa, Y. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110428 · Cited by 6

NBD-BPEA regulates Zn2+- or Cu2+-induced Aβ40 aggregation and cytotoxicity

Chen, T., Zhang, Y., Shang, Y., Gu, X., Zhu, Y. P., & Zhu, L. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.03.035 · Cited by 6

AD-Syn-Net: systematic identification of Alzheimer’s disease-associated mutation and co-mutation vulnerabilities via deep learning

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Studying the relationship between cell cycle and Alzheimer's disease by gold nanoparticle probes

Wang, C., & Wang, Z. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.08.014 · Cited by 6

Inhibition of Amyloid β Fibrillation by Nanoparticles Composed of Ovalbumin-derived Amphiphilic Peptides

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Molecular Dynamics Simulation and Binding Free Energy Calculation of the Conformational Transition of Amyloid Peptide 42 Inhibited by Peptide Inhibitors

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An activity prediction model for steroidal and triterpenoidal inhibitors of Acetylcholinesterase enzyme

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Insights into β-amyloid transition prevention by cucurbit[7]uril from molecular modeling

de Oliveira, O. V., Gonçalves, A. D. S., & de Almeida, N. E. C. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1932600 · Cited by 6

Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer’s Amyloid β‐Peptide Aggregation

Sylla, T., Pouységu, L., Costa, G. D., Deffieux, D., Monti, J., & Quideau, S. (2015) · Angewandte Chemie · doi:10.1002/ange.201411606 · Cited by 6

COB231 targets amyloid plaques in post‐mortem human brain tissue and in an Alzheimer mouse model

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Investigation of Some Metabolic Enzyme Inhibition Properties of Novel Chalcone‐Cu Complexes

Ebiri, R., Turgut, M., Anıl, D. A., Demir, Y., Sağlamtaş, R., Alagöz, M. A., Algül, Ö., & Burmaoğlu, S. (2024) · ChemistrySelect · doi:10.1002/slct.202401093 · Cited by 5

The Aggregation Potential of the 1–15- and 1–16-Fragments of the Amyloid β Peptide and Their Influence on the Aggregation of Aβ40

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Design, synthesis, and evaluation of 8-aminoquinoline-melatonin derivatives as effective multifunctional agents for Alzheimer’s disease

Chen, Z., Yu, X., Chen, L., Xu, L., Cai, Y., Hou, S., Zheng, M., & Liu, F. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-730 · Cited by 5

Protein Corona Formation and Aggregation of Amyloid β 1–40-Coated Gold Nanocolloids

Yokoyama, K., Barbour, E., Hirschkind, R., Hernandez, B. M., Hausrath, K. A., & Lam, T. (2024) · Langmuir · doi:10.1021/acs.langmuir.3c02923 · Cited by 5

Ethanol Exacerbates the Alzheimer’s Disease Pathology in the 5xFAD Mouse Model

Mohammed, H. E., Nelson, J. C., & Marshall, S. A. (2024) · Neuroglia · doi:10.3390/neuroglia5030020 · Cited by 5

Studies on the bioactivities of 8-mercaptoquinoline sulfide derivatives

Zhang, J.-A., Zhang, L., Zou, X.-Z., Liu, Y., Gao, W., & Li, Y. (2015) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2015.11.017 · Cited by 5

Chimeric Conjugates for Alzheimer’s Disease

Dhala, I., Khan, T. A., & Prabhu, A. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch10 · Cited by 5

Molecular Integrative Analysis of the Inhibitory Effects of Dipeptides on Amyloid β Peptide 1–42 Polymerization

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PEGylated β‐Sheet Breaker Peptides as Inhibitors of β‐Amyloid Fibrillization

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Imaging in Neurology Research II: PET Imaging of CNS Disorders

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Excited-state intramolecular-proton-transfer-based fluorescent probe for the rapid detection of peroxynitrite in Alzheimer’s disease models

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Unsymmetric indolylmaleimides: Synthesis, photophysical properties and amyloid detection

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Chromosomal DNA damage in APOE ɛ4 carriers and noncarriers does not appear to be different

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The role of ligand covalency in the selective activation of metalloenediynes for Bergman cyclization

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Brain neurotrophic supply in ontogenesis and during development of neurodegenerative diseases

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Multi‐Frequency, Multi‐Technique Pulsed EPR Investigation of the Copper Binding Site of Murine Amyloid β Peptide

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34 GHz Pulsed ENDOR Characterization of the Copper Coordination of an Amyloid β Peptide Relevant to Alzheimer’s Disease

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A cationic amphiphilic peptide chaperone rescues Aβ 42 aggregation and cytotoxicity

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Design, Synthesis and Evaluation of Catechol-Based Amyloid Beta Aggregation Inhibitors

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Lung nodules after whole lung radiation.

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From bench to brain: novel thieno-oxazine hybrids as potent pleiotropic anti-Alzheimer’s agents with in vivo / in vitro validation and in silico insights

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Ligand steric effects of nano-inhibitors on Aβ fibrillation at the nano-bio interfaces

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Insight into the activation mechanism of carbonic anhydrase( ii ) through 2-(2-aminoethyl)-pyridine: a promising pathway for enhanced enzymatic activity

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Apply the Feature of Entropy Convergence of ACO to Short the Runtime of Gene Order

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Protein interaction in the mechanism of platinum anticancer drugs

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Native Mass Spectrometry-Centric Approaches Revealed That Neuropeptides Frequently Interact with Amyloid-β

Wang, D., Wang, G., Wang, X., Ren, Z., & Jia, C. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00075 · Cited by 3

Design and Synthesis of Novel Arylketo-containing P1-P3 Linked Macro-cyclic BACE-1 Inhibitors

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ALZHEIMER’S DISEASE THERAPEUTIC APPROACHES

Sandhya, A., & Gomathi, K. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i7.25104 · Cited by 3

Substituted Aminobenzothiazole Derivatives of Tacrine: Synthesis and Study on Learning and Memory Impairment in Scopolamine-Induced Model of Amnesia in Rat

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Sialic Acid Conjugated Chitosan for the Attenuation of Amyloid-beta Toxicity

Dhavale, D. D. (2009) · Louisiana State University · doi:10.31390/gradschool_theses.3810 · Cited by 3

Navigating into the paradigm of lactoferrin surface modified nanocarriers in the management of central nervous system disorders

Desai, A., Shah, P., & Jain, S. (2025) · Polymer Bulletin · doi:10.1007/s00289-025-05881-6 · Cited by 2

(Gd3+) Complexation with oligopeptide (SFVG) and amyloid peptide (Aβ13–23) in aqueous solution by NMR spectroscopy

Tarasov, A. S., Зуфарович, Р. И., Blokhin, D. S., Klochkov, A. V., Il'yasov, K. A., & Klochkov, V. V. (2023) · Results in Chemistry · doi:10.1016/j.rechem.2023.100762 · Cited by 2

Metal Chelators as a Potential Therapeutic Agent for Alzheimer’s Disease

Dewangan, B., Kumar, K., Kumar, A., Bodhe, P. R., Beni, S., & Sahu, B. (2023) · Springer eBooks · doi:10.1007/978-981-99-6038-5_13 · Cited by 2

An easy-to-perform method for microvessel isolation and primary brain endothelial cell culture to study Alzheimer's disease

Chen, Y., Huang, X., Chen, H., & Yi, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33077 · Cited by 2

Protective effects of Populus tomentiglandulosa against cognitive impairment by regulating oxidative stress in an amyloid beta25–35-induced Alzheimer's disease mouse model

Kwon, Y. R., Kim, J.-H., Lee, S., Kim, H. Y., & Cho, E. J. (2022) · Nutrition Research and Practice · doi:10.4162/nrp.2022.16.2.173 · Cited by 2

Structure–Function Studies of Amyloid Pores in Alzheimer’s Disease as a Case Example of Neurodegenerative Diseases

Arce, F. T., Jang, H., Connelly, L. S., Ramachandran, S., Kagan, B. L., Nussinov, R., & Lal, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394431-3.00036-5 · Cited by 3

Study on Neuroprotective Capacity of Key Flavonoids of Ampelopsis grossedentata

Wang, J.-S., Yu, Z., Yu, Q., Kong, Q., Zhang, N., He, L., & Yi, Y. (2014) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-2-12-4 · Cited by 2

UDP-glucose glycoprotein glucosyltransferase (uggt-1) and UPR genes modulate C. elegans necrotic cell death

López, N. (2009) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3m61kdj · Cited by 2

Foldamers as Inhibitors of Aberrant Protein–Protein Interactions

Stillman, N. H., Dohoney, R. A., Baysah, C. Z., & Kumar, S. (2025) · Wiley eBooks · doi:10.1002/9783527845828.ch8 · Cited by 2

Études chimiques et biologiques d’Aframomum sceptrum (Zingiberaceae) et de la curcumine

Ali, Z. C. (2012) · theses.fr (ABES) · doi:10.70675/4e65670cz316dz4863z864bz3bba45c761c7 · Cited by 2

Protein misfolding, aggregation and other factors determining the amyloidogenic landscape of human leucocyte chemotaxin-2: A review

Kumar, A., Lakhawat, S. S., Malik, N. K., Sharma, V., Singh, Y., Jain, A., Sharma, V., Singh, S. K., & Sharma, P. K. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110500 · Cited by 1

Polymeric Nanocarriers for Enhanced Blood-Brain Barrier Permeation in Neurological Drug Delivery

Talele, C., Aundhia, C. J., Talele, D. R., Shah, N., Kumari, M., & Sadhu, P. (2025) · Micro and Nanosystems · doi:10.2174/0118764029366173250706232958 · Cited by 1

In-silico investigation of the molecular disruption of Aβ42 protofibril by stilbenoids

Dey, C., Singh, P. P., & Chakraborty, S. (2026) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2026.2621265 · Cited by 1

Developments on BACE 1 Inhibitors as Anti‐Alzheimer Agents: A Perspective on Medicinal Chemistry‐Based Advances

Ali, N., Alotaibi, F. T., Babu, M. A., Singh, T., Tyagi, Y., Alotaibi, A. N., Bansal, N., & Puri, S. (2026) · Archiv der Pharmazie · doi:10.1002/ardp.70220 · Cited by 1

Disease-associated RNA and protein signatures in iPSC-derived microglia model of Alzheimer’s disease

Wu, W., Choi, E. S., Liu, L., Thamilselvan, V., LI, L., Rippee‐Brooks, M. D., Khatkar, K., Li, D.-Y., McGrath, D., Manning, A. C., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1799542 · Cited by 1

Oxidative stress and inflammation in neurodegenerative disorders

Jomová, K., Alomar, S. Y., Valko, R., Nepovimová, E., Kuča, K., & Valko, M. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04518-5 · Cited by 1

Small molecule NPT-440-1 inhibits ionic flux through Aβ 1-42 pores: Implications for Alzheimer's disease therapeutics

Gillman, A. L., Lee, J., Ramachandran, S., Capone, R. F., Gonzalez, T., Wrasidlo, W., Masliah, E., & Lal, R. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.06.001 · Cited by 1

Unveiling Nature’s Arsenal: Natural Sources for Drug Discovery in Alzheimer’s Disease

Remya, C., Aiswarya, N., & Dileep, K. V. (2024) · Springer eBooks · doi:10.1007/978-981-99-9183-9_13 · Cited by 1

Significant downregulation of Alzheimer's amyloid-β levels enabled by engineered DNA nanomaterials

Sun, Y., Sun, J. W., Feng, Y., Zhang, Y., Li, J., Wang, F., Loznik, M., Tian, Y., Zhang, H., Herrmann, A. P., et al. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.03.017 · Cited by 1

Current Perspectives of Nanotherapeutics for the Treatment of Alzheimer’s Disease

Mishra, S., Senthilkumar, D., & Yadav, V. K. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815256505124010010 · Cited by 1

Structure-Based Ligand Design I

Sun, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-100098-4.00002-8 · Cited by 1

Therapeutic Potential of Phytoestrogens

Fatima, A., Alam, A., & Singh, R. (2018) · Springer eBooks · doi:10.1007/978-981-13-1123-9_15 · Cited by 1

Efficacy of Multifunctionalized Saccharide Constructs for the Attenuation of Amyloid-beta Toxicity

Dhavale, D. D. (2012) · Louisiana State University · doi:10.31390/gradschool_dissertations.2446 · Cited by 1

The dynamic nature of amyloid-beta protein aggregation and its association to Alzheimer’s disease

Vilaprinyó-Pascual, S. (2015) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

Die Amyloidablagerung in einem Mausmodell der Alzheimer Demenz und die Modulation der β-Amyloid-Peptidentstehung durch membranverankerte Inhibitoren

Schieb, H. (2011) · DuEPublico (University of Duisburg-Essen)

Efeito da perda de peso induzida por cirurgia bariátrica sobre metabolismo cerebral e função cognitiva

Marques, E. L. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2014.tde-24102014-104455

Derivados da cafeína como moderadores do estresse oxidativo provocado por sobrecarga de ferro

Pastrana, E. C. (2014) · doi:10.11606/d.46.2014.tde-30092014-090833

Study of the aggregation process of the amyloid beta-protein associated to Alzheimer's disease. Examination of pharmaceutically important small molecules.

Vidal, B. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

The Effect of Acute LPS-Induced Immune Activation and Brain Insulin Signaling Disruption in a Diabetic Model of Alzheimer's Disease

Murtishaw, A. S. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/6456429

The Alzheimer s disease related gamma-secretase complex : Localization and novel interacting proteins

Hur, J. (2010) · Figshare

"Identificación de regiones clave en el proceso de agregación y citotoxicidad del péptido β-amiloide"

León, N., & Medicina, F. D. (2014)

Aβ Fibril Polymorphism and Alzheimer’s Disease

Bereza, M., & Fändrich, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394431-3.00017-1

Stability and folding of G-protein coupled receptors associated to degenerative diseases

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ChemInform Abstract: Alzheimer′s Disease: From Pathology to Therapeutic Approaches

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