Alzheimer's Disease: From Pathology to Therapeutic Approaches

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Inflammation and Alzheimer’s disease

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Mild cognitive impairment

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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34 GHz Pulsed ENDOR Characterization of the Copper Coordination of an Amyloid β Peptide Relevant to Alzheimer’s Disease

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Multifunctionality of self-assembled nanogels of curcumin-hyaluronic acid conjugates on inhibiting amyloid β-protein fibrillation and cytotoxicity

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Tautomeric Effect of Histidine on the Monomeric Structure of Amyloid β-Peptide(1–40)

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A simple aptasensor for Aβ40 oligomers based on tunable mismatched base pairs of dsDNA and graphene oxide

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Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease

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Iron in Alzheimer’s Disease: From Physiology to Disease Disabilities

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Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation

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Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer’s disease agents

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Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ 42 Oligomers

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Activity and Architecture of Pyroglutamate-Modified Amyloid-β (AβpE3-42) Pores

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Protective effects of luteolin against cognitive impairment induced by infusion of Aβ peptide in rats.

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Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity

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Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics

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Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease

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Multiple Function Fluorescein Probe Performs Metal Chelation, Disaggregation, and Modulation of Aggregated Aβ and Aβ-Cu Complex

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An ultrasensitive electrochemical immunosensor for apolipoprotein E4 based on fractal nanostructures and enzyme amplification

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Co-assembly of polyoxometalates and peptides towards biological applications

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Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents

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Bis(7)‐tacrine Derivatives as Multitarget‐Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

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Hippocampal neuronal metal ion imbalance related oxidative stress in a rat model of chronic aluminum exposure and neuroprotection of meloxicam

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Exploring the Reactions of β-Amyloid (Aβ) Peptide 1–28 with AlIII and FeIII Ions

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The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor

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Design of peptide-based inhibitor agent against amyloid-β aggregation: Molecular docking, synthesis and in vitro evaluation

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Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation

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Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer’s Disease?

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Recent discoveries and applications involving small-molecule microarrays

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Se/Ru nanoparticles as inhibitors of metal-induced Aβ aggregation in Alzheimer's disease

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Ultrasmall superparamagnetic iron oxide nanoparticles-bound NIR dyes: Novel theranostic agents for Alzheimer's disease

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Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease

Lan, J., Zeng, R., Jiang, X., Hou, J., Liu, Y., Hu, Z.-H., Li, H., Li, Y., Xie, S., Ding, Y., et al. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103413 · Cited by 41

Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function

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Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs

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Insight into the Inhibition Effect of Acidulated Serum Albumin on Amyloid β-Protein Fibrillogenesis and Cytotoxicity

Xie, B., Li, X., Dong, X., & Sun, Y. P. (2014) · Langmuir · doi:10.1021/la5025197 · Cited by 40

Azo-dyes based small bifunctional molecules for metal chelation and controlling amyloid formation

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A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

Kim, H. J., Jang, B. K., Park, J., Choi, J., Park, S. J., Byeon, S. R., Pae, A. N., Lee, Y. S., Cheong, E., & Park, K. D. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111777 · Cited by 40

Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · Biology · doi:10.3390/biology9060122 · Cited by 44

Metallostasis and amyloid β-degrading enzymes

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An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly

Doran, T. M., Anderson, E. A., Latchney, S. E., Opanashuk, L. A., & Nilsson, B. L. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn2001188 · Cited by 40

Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease

Jiang, N., Li, S., Xie, S., Li, Z., Wang, K. D. G., Wang, X., & Kong, L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.10.004 · Cited by 39

Inhibitory Activity of Curcumin Derivatives Towards Metal-Free and Metal-Induced Amyloid-β Aggregation

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Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease

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Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-β Species

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Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease

Derrick, J. S., & Lim, M. H. (2015) · ChemBioChem · doi:10.1002/cbic.201402718 · Cited by 39

Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

Su, T., Zhang, T., Xie, S., Yan, J., Wu, Y., Li, X., Huang, L., & Luo, H. (2016) · Scientific Reports · doi:10.1038/srep21826 · Cited by 38

A Near‐Infrared Responsive Drug Sequential Release System for Better Eradicating Amyloid Aggregates

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PtCl2(phen) disrupts the metal ions binding to amyloid-β peptide

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Dual Role of Gold Nanorods: Inhibition and Dissolution of Aβ Fibrils Induced by Near IR Laser

Swathi, S., Santhosh, P. B., & Mani, E. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00238 · Cited by 37

Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions

Tian, Z.-Y., Wang, C., Wang, T., Li, Y., & Wang, Z. (2018) · Aging and Disease · doi:10.14336/ad.2018.0912 · Cited by 37

Derivatives and Analogues of Resveratrol: Recent Advances in Structural Modification

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Confinement fluorescence effect (CFE): Lighting up life by enhancing the absorbed photon energy utilization efficiency of fluorophores

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An ultrathin graphitic carbon nitride nanosheet: a novel inhibitor of metal-induced amyloid aggregation associated with Alzheimer's disease

Li, M., Guan, Y., Ding, C., Chen, Z., Ren, J., & Qu, X. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01215a · Cited by 37

Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates

Martins, P. A. T., Alsaiari, S. K., Julfakyan, K., Nie, Z., & Khashab, N. M. (2017) · Chemical Communications · doi:10.1039/c6cc09085k · Cited by 36

A rapid and sensitive detection of ferritin at a nanomolar level and disruption of amyloid β fibrils using fluorescent conjugated polymer

Balakrishnan, M., Hussain, S., & Iyer, P. K. (2013) · Polymer Chemistry · doi:10.1039/c3py00680h · Cited by 36

Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease

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Effects of Fructus Akebiae on learning and memory impairment in a scopolamine-induced animal model of dementia

Wang, J., Wang, X., Lv, B., Yuan, W., Feng, Z., Mi, W., & ZHANG, H. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1775 · Cited by 36

BACE1 Inhibitory Meroterpenoids from Aspergillus terreus

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New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus

Qi, C., Qiao, Y., Gao, W., Liu, M., Zhou, Q. Y., Chen, C., Lai, Y., Xue, Y., Zhang, J., Li, D., et al. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob02741b · Cited by 36

Rapid Dissolution of Amyloid β Fibrils by Silver Nanoplates

Swathi, S., & Mani, E. (2019) · Langmuir · doi:10.1021/acs.langmuir.9b00080 · Cited by 36

Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer’s Disease Brain and Olfactory Epithelium

Gu, J., Anumala, U. R., Haußen, R. H., Hölzer, J., Goetschy, V., Mall, G., Hilger, I., Czech, C., & Schmidt, B. (2013) · ChemMedChem · doi:10.1002/cmdc.201300090 · Cited by 36

Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation

Lee, H. J., Kerr, R. A., Korshavn, K. J., Lee, J., Kang, J., Ramamoorthy, A., Ruotolo, B. T., & Lim, M. H. (2016) · Inorganic Chemistry Frontiers · doi:10.1039/c5qi00219b · Cited by 36

A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

Yang, S., Liu, W., Lü, S., Tian, Y., Wang, W., Ling, T.-J., & Liu, R. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00091 · Cited by 36

HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms

Hu, L.-T., Zhu, B.-L., Lai, Y.-J., Long, Y., Zha, J.-S., Hu, X.-T., Zhang, J. H., & Chen, G.-J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.03.069 · Cited by 35

Aptamer-Induced-Dimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrPC Signaling

Liu, S., Li, S., Lin, J., Li, J., & Yang, H. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c00287 · Cited by 36

Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid-β Aggregation and Acetylcholinesterase-Amyloid Interaction

Álvarez-Berbel, I., Espargaró, A., Viayna, A., Caballero, A. B., Busquets, M. A., Gámez, P., Luque, F. J., & Sabaté, R. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112342 · Cited by 37

Hexafluoroisopropanol induces self‐assembly of β‐amyloid peptides into highly ordered nanostructures

Pachahara, S. K., Chaudhary, N., Subbalakshmi, C., & Nagaraj, R. (2012) · Journal of Peptide Science · doi:10.1002/psc.2391 · Cited by 33

Dihydroquinoline Carbamate Derivatives as “Bio-oxidizable” Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [11C] Radiosynthesis and Biological Evaluation

Bohn, P., Gourand, F., Papamicaël, C. A., Ibazizène, M., Dhilly, M., Gembus, V., Allix, F., Ţînţaş, M.-L., Marsais, F., Barré, L., et al. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn5003539 · Cited by 35

Rationally Designed CeNP@MnMoS4 Core‐Shell Nanoparticles for Modulating Multiple Facets of Alzheimer's Disease

Guan, Y., Gao, N., Ren, J., & Qu, X. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201603233 · Cited by 35

Protein Kinase C (PKC) in Neurological Health: Implications for Alzheimer’s Disease and Chronic Alcohol Consumption

Singh, N., Nandy, S. K., Jyoti, A., Saxena, J., Sharma, A., Siddiqui, A. J., & Sharma, L. K. (2024) · Brain Sciences · doi:10.3390/brainsci14060554 · Cited by 35

Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation

Jones, M. R., Dyrager, C., Hoarau, M., Korshavn, K. J., Lim, M. H., Ramamoorthy, A., & Storr, T. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.04.022 · Cited by 34

n Bu 4 NPF 6 promoted regioselective cascade synthesis of functionally embellished naphthofurans under acid, metal & solvent free conditions

Pareek, A., Dada, R., Rana, M., Sharma, A. K., & Yaragorla, S. (2016) · RSC Advances · doi:10.1039/c6ra17411f · Cited by 34

Date seed extract ameliorates β-amyloid-induced impairments in hippocampus of male rats

Dehghanian, F., Kalantaripour, T. P., Esmaeilpour, K., Elyasi, L., Oloumi, H., Pour, F. M., & Asadi‐Shekaari, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.037 · Cited by 36

2-Substituted-thio- N -(4-substituted-thiazol/1 H -imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies

Yan, G., Hao, L., Niu, Y., Huang, W., Wang, W., Xu, F., Liang, L., Wang, C., Jin, H., & Xu, P. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.06.020 · Cited by 34

Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications

Sgarlata, C., Arena, G., Bonomo, R. P., Giuffrida, A., & Tabbı̀, G. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.12.002 · Cited by 36

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer’s disease

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Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases

Hügel, H., & Jackson, N. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712800493906 · Cited by 34

Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies

Li, C., Guo, X., Lei, M., Wu, J., Jin, J.-Z., Shi, X., Zhu, Z., Rukachaisirikul, V., Hu, L., Wen, T., et al. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.94 · Cited by 33

Liquid-liquid phase separation in Alzheimer’s disease

Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33

Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones

Fosso, M. Y., LeVine, H., Green, K. D., Tsodikov, O. V., & Garneau‐Tsodikova, S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01478f · Cited by 33

Therapeutic efficacy of stemazole in a beta-amyloid injection rat model of Alzheimer's disease

Han, M., Liu, Y. M., Tan, Q., Zhang, B., Wang, W., Liu, J., Zhang, X., Wang, Y., & Zhang, J. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.01.065 · Cited by 33

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity

Chand, K., Alsoghier, H. M., Chaves, S., & Santos, M. A. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.05.005 · Cited by 33

Azo-Stilbene and Pyridine–Amine Hybrid Multifunctional Molecules to Target Metal-Mediated Neurotoxicity and Amyloid-β Aggregation in Alzheimer’s Disease

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Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations

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Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

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Carnosine-LVFFARK-NH2 Conjugate: A Moderate Chelator but Potent Inhibitor of Cu2+-Mediated Amyloid β-Protein Aggregation

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Turn Nucleation Perturbs Amyloid β Self-Assembly and Cytotoxicity

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The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer’s disease amyloid-β peptides

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Chemical strategies to modify amyloidogenic peptides using iridium( iii ) complexes: coordination and photo-induced oxidation

Kang, J., Nam, J. S., Lee, H. J., Nam, G., Rhee, H., Kwon, T., & Lim, M. H. (2019) · Chemical Science · doi:10.1039/c9sc00931k · Cited by 32

Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom

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Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

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Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter‐Related Pathological Features in Alzheimer's Disease

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New classes of carbazoles as potential multi-functional anti-Alzheimer’s agents

Choubdar, N., Golshani, M., Jalili‐Baleh, L., Nadri, H., Küçükkılınç, T. T., Ayazgök, B., Moradi, A., Moghadam, F. H., Abdolahi, Z., Ameri, A., et al. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103164 · Cited by 32

The pathomimetic oAβ25–35 model of Alzheimer's disease: Potential for screening of new therapeutic agents

Canet, G., Zussy, C., Hernandez, C., Maurice, T., Desrumaux, C. M., & Givalois, L. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108398 · Cited by 34

Isotope-Labeling of the Fibril Binding Compound FSB via a Pd-Catalyzed Double Alkoxycarbonylation

Burhardt, M. N., Taaning, R. H., Nielsen, N. C., & Skrydstrup, T. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo300746x · Cited by 31

Dementia treatment versus prevention

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Nanomedicine-based immunotherapy for Alzheimer's disease

Hoque, M., Samanta, A., Alam, S. S. M., Zughaibi, T. A., Kamal, M. A., & Tabrez, S. S. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104973 · Cited by 31

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species

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Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications

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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

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Real-time monitoring of the aggregation of Alzheimer's amyloid-β via 1 H magic angle spinning NMR spectroscopy

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Disassembly of preformed amyloid beta fibrils by small organofluorine molecules

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Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer’s Aβ peptide

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Die Alzheimer‐Demenz: von der Pathologie zu therapeutischen Ansätzen

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The Role and Therapeutic Targeting of α-, β- and γ-Secretase in Alzheimer's Disease

MacLeod, R., Hillert, E., Cameron, R. T., & Baillie, G. S. (2015) · Future Science OA · doi:10.4155/fso.15.9 · Cited by 136

Progress towards testing the amyloid hypothesis: inhibitors of APP processing.

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β-Amyloid therapies in Alzheimer’s disease

Jhee, S. S., Shiovitz, T. M., Crawford, A. W., & Cutler, N. R. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.4.593 · Cited by 25

Views on Amyloid Hypothesis and Secretase Inhibitors for Treating Alzheimers Disease: Progress and Problems

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