Alzheimer's Disease: From Pathology to Therapeutic Approaches

Cited by (663)

Items 101–200 of 663

1. The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions
   Ann Tiiman, Peep Palumaa, Vello Tõugu · 2013 · Neurochemistry International
2. Mitochondrial therapeutic interventions in Alzheimer’s disease
   Vo Van Giau, Seong Soo A. An, John Hulme · 2018 · Journal of the Neurological Sciences
3. Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs
   Hyunbum Jang, Fernando Terán Arce, Srinivasan Ramachandran, Bruce L. Kagan, Ratnesh Lal, Ruth Nussinov · 2014 · Chemical Society Reviews
4. Nanomaterials toward the treatment of Alzheimer’s disease: Recent advances and future trends
   Huihui Zeng, Yujie Qi, Zheyu Zhang, Chuntai Liu, Weijun Peng, Yi Zhang · 2021 · Chinese Chemical Letters
5. Natural Compounds May Open New Routes to Treatment of Amyloid Diseases
   Jan Bieschke · 2013 · Neurotherapeutics
6. Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer’s disease
   Yang Xia, Xiaoming Qiang, Yan Li, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng · 2017 · Bioorganic Chemistry
7. β-Sheet interfering molecules acting against β-amyloid aggregation and fibrillogenesis
   Antonio Francioso, Pasqualina Punzi, Alberto Boffi, Clorinda Lori, Sara Martire, Cesare Giordano, Maria D’Erme, Luciana Mosca · 2015 · Bioorganic & Medicinal Chemistry
8. Amyloid Clearance as a Treatment Target Against Alzheimer's Disease
   Alexander Kurz, Robert Perneczky · 2011 · Journal of Alzheimer s Disease
9. Reaction Rates and Mechanism of the Ascorbic Acid Oxidation by Molecular Oxygen Facilitated by Cu(II)-Containing Amyloid-β Complexes and Aggregates
   Dianlu Jiang, Xiangjun Li, Lin Liu, Gargey B. Yagnik, Feimeng Zhou · 2010 · The Journal of Physical Chemistry B
10. Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
    Fahadul Islam, Jannatul Fardous Khadija, Md. Harun-Or-Rashid, Md. Saidur Rahaman, Mohamed H. Nafady, Md. Rezaul Islam, Aklima Akter, Talha Bin Emran, Polrat Wilairatana, Mohammad Suleiman Mubarak · 2022 · Oxidative Medicine and Cellular Longevity
11. Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines
    Shigao Yang, Weiyun Wang, Tie-Jun Ling, Ying Feng, Xueting Du, Xi Zhang, Xiaoxia Sun, Min Zhao, Di Xue, Yang Yang · 2010 · Neurochemistry International
12. Natural products and their derivatives as multifunctional ligands against Alzheimer's disease
    Pooja Patil, Ashima Thakur, Abha Sharma, Swaran J.S. Flora · 2019 · Drug Development Research
13. Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders
    Basharat Ahmad Bhat, Abdullah Almilaibary, Rakeeb Ahmad Mir, Badr M. Aljarallah, Wajahat Rashid Mir, Fuzail Ahmad, Manzoor Ahmad Mir · 2022 · Frontiers in Neuroscience
14. Melatonin Attenuates Memory Impairment, Amyloid-β Accumulation, and Neurodegeneration in a Rat Model of Sporadic Alzheimer’s Disease
    Ekaterina A. Rudnitskaya, Natalia A. Muraleva, Kseniya Yi. Maksimova, Киселева Елена Владимировна, Nataliya G. Kolosova, Natalia A. Stefanova · 2015 · Journal of Alzheimer s Disease
15. Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease
    Joana Machado Oliveira, Márcio Gilberto Cardoso Costa, Maria Cachide, Odete A. B. da Cruz e Silva, Ana Gabriela Henriques · 2017 · Journal of Alzheimer s Disease
16. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology
    Ana Martinez Hernandez, Hendrik Urbanke, Alan L. Gillman, Joon Lee, Sergey Ryazanov, H.Y. Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian et al. · 2017 · EMBO Molecular Medicine
17. Key Residue for Aggregation of Amyloid-β Peptides
    Satoru Itoh, Maho Yagi‐Utsumi, Koichi Kato, Hisashi Okumura · 2022 · ACS Chemical Neuroscience
18. Photodegradation of β-sheet amyloid fibrils associated with Alzheimer's disease by using polyoxometalates as photocatalysts
    Meng Cathy Li, Can Xu, Jinsong Ren, Enbo Wang, Xiaogang Qu · 2013 · Chemical Communications
19. Identification of [PtCl2(phen)] Binding Modes in Amyloid‐β Peptide and the Mechanism of Aggregation Inhibition
    Guolin Ma, Fan Huang, Xuewei Pu, Liangyuan Jia, Tao Jiang, Lianzhi Li, Yangzhong Liu · 2011 · Chemistry - A European Journal
20. Multitarget Strategies in Alzheimer’S Disease: Benefits and Challenges on the Road to Therapeutics
    Michela Rosini, Elena Simoni, Roberta Caporaso, Anna Minarini · 2016 · Future Medicinal Chemistry
21. Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity
    Sunil Kumar, Anja Henning‐Knechtel, Ibrahim Chehade, Mazin M. Magzoub, Andrew D. Hamilton · 2017 · Journal of the American Chemical Society
22. Dual-Channel Imaging of Amyloid-β Plaques and Peroxynitrite To Illuminate Their Correlations in Alzheimer’s Disease Using a Unimolecular Two-Photon Fluorescent Probe
    Xilei Xie, Guangzhao Liu, Yaxin Niu, Cheng‐Hui Xu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang, Bo Tang · 2021 · Analytical Chemistry
23. Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03
    Xueyun Zheng, Deyu Liu, Frank‐Gerrit Klärner, Thomas H. Schrader, Gal Bitan, Michael T. Bowers · 2015 · The Journal of Physical Chemistry B
24. Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging
    Alexei A. Podtelezhnikov, Keith Quincy Tanis, Michael Nebozhyn, William J. Ray, David J. Stone, Andrey P. Loboda · 2011 · PLoS ONE
25. Quinolone–benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease
    Marc Pudlo, Vincent Luzet, Lhassane Ismaïli, Isabelle Tomassoli, Anne Iutzeler, Bernard Refouvelet · 2014 · Bioorganic & Medicinal Chemistry
26. The overall impairment of core executive function components in patients with amnestic mild cognitive impairment: a cross-sectional study
    Dongming Zheng, Xiaoyu Dong, Hongzan Sun, Yongchuan Xu, Ying Ma, Xiaoming Wang · 2012 · BMC Neurology
27. Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer’s disease
    Bruno Tasso, Marco Catto, Orazio Nicolotti, Federica Novelli, Michele Tonelli, Ilenia Giangreco, Leonardo Pisani, Anna Sparatore, Vito Boido, Angelo Carotti et al. · 2011 · European Journal of Medicinal Chemistry
28. Inhibition of Amyloid-β Aggregation by Cobalt(III) Schiff Base Complexes: A Computational and Experimental Approach
    Aysenur Iscen, Christopher R. Brue, Kaleigh F. Roberts, Joy Kim, George Chappell Schatz, Thomas J. Meade · 2019 · Journal of the American Chemical Society
29. Supramolecular Exchange among Assemblies of Opposite Charge Leads to Hierarchical Structures
    James R. Wester, Jacob A. Lewis, Ronit Freeman, Hiroaki Sai, Liam C. Palmer, Stephen E. Henrich, Samuel Isaac Stupp · 2020 · Journal of the American Chemical Society
30. A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease
    Michael W. Beck, Shin Bi Oh, Richard A. Kerr, Hyuck Jin Lee, Sohee Kim, Sujeong Kim, Milim Jang, Brandon T. Ruotolo, Joo‐Yong Lee, Mi Hee Lim · 2015 · Chemical Science
31. Metal-involved theranostics: An emerging strategy for fighting Alzheimer’s disease
    Xiaohui Wang, Xiaoyong Wang, Zijian Guo · 2018 · Coordination Chemistry Reviews
32. Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation
    Jong‐Min Suh, Gunhee Kim, Juhye Kang, Mi Hee Lim · 2018 · Inorganic Chemistry
33. Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer’s Amyloid β‐Peptide Aggregation
    Tahiri Sylla, Laurent Pouységu, Grégory Da Costa, Denis Deffieux, Jean‐Pierre Monti, Stéphane Quideau · 2015 · Angewandte Chemie International Edition
34. A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms
    Jeffrey S. Derrick, Richard A. Kerr, Younwoo Nam, Shin Bi Oh, Hyuck Jin Lee, Kaylin G. Earnest, Nayoung Suh, Kristy L. Peck, Mehmet Özbil, Kyle J. Korshavn et al. · 2015 · Journal of the American Chemical Society
35. Carnosine's Effect on Amyloid Fibril Formation and Induced Cytotoxicity of Lysozyme
    Josephine W. Wu, Kuan-Nan Liu, Su-Chun How, Wei‐An Chen, Chia-Min Lai, Hwai-Shen Liu, Chaur‐Jong Hu, Steven S.‐S. Wang · 2013 · PLoS ONE
36. Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease
    Hongbing Huang, Daniel S. La, Alan C. Cheng, Douglas A. Whittington, Vinod F. Patel, Kui Chen, Thomas A. Dineen, Oleg I. Epstein, Russell F. Graceffa, Dean Hickman et al. · 2012 · Journal of Medicinal Chemistry
37. Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides
    Jeffrey S. Derrick, Jiwan Lee, Shin Jung C. Lee, Yujeong Kim, Eunju Nam, Hyeonwoo Tak, Juhye Kang, Misun Lee, Sun Hee Kim, Kiyoung Park et al. · 2017 · Journal of the American Chemical Society
38. Real‐time Tracking and Sensing of Cu + and Cu 2+ with a Single SERS Probe in the Live Brain: Toward Understanding Why Copper Ions Were Increased upon Ischemia
    Jiaqi Liu, Zhichao Liu, Wei-Kang Wang, Yang Tian · 2021 · Angewandte Chemie International Edition
39. Novel 8-hydroxyquinoline derivatives targeting β-amyloid aggregation, metal chelation and oxidative stress against Alzheimer’s disease
    Xuelian Yang, Pei Cai, Qiaohong Liu, Jia‐Jia Wu, Yong Yin, Xiaobing Wang, Ling‐Yi Kong · 2018 · Bioorganic & Medicinal Chemistry
40. Hydroxylated Single-Walled Carbon Nanotubes Inhibit Aβ42 Fibrillogenesis, Disaggregate Mature Fibrils, and Protect against Aβ42-Induced Cytotoxicity
    Fufeng Liu, Wenjuan Wang, Jingcheng Sang, Longgang Jia, Fuping Lu · 2018 · ACS Chemical Neuroscience
41. A score years’ update in the synthesis and biological evaluation of medicinally important 2-pyridones
    Sarita Sangwan, Neelam R. Yadav, Ravi Kumar, Sonu Chauhan, Vidhi Dhanda, Pooja Walia, Anil Duhan · 2022 · European Journal of Medicinal Chemistry
42. Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents
    Lei Fang, Xubin Fang, Shaohua Gou, Amelie Lupp, Isabell Lenhardt, Haopeng Sun, Zhangjian Huang, Yao Chen, Yihua Zhang, Christian Fleck · 2014 · European Journal of Medicinal Chemistry
43. Amyloid β-Targeted Metal Complexes for Potential Applications in Alzheimer's Disease
    Hao Liu, Yunwei Qu, Xiaohui Wang · 2018 · Future Medicinal Chemistry
44. The Amyloid-β Oligomer Count in Cerebrospinal Fluid is a Biomarker for Alzheimer's Disease
    Lei Wang‐Dietrich, Susanne Aileen Funke, Katja Kühbach, Kun Wang, Astrid Besmehn, Sabine Willbold, Yeliz Cinar, Oliver Bannach, Eva Birkmann, Dieter Willbold · 2013 · Journal of Alzheimer s Disease
45. Positron emission tomography radioligands for in vivo imaging of Aβ plaques
    Neale Scott Mason, Chester A. Mathis, William Edward Klunk · 2013 · Journal of Labelled Compounds and Radiopharmaceuticals
46. Rational Design of β-Sheet Ligands Against Aβ42-Induced Toxicity
    Katrin Hochdörffer, Julia März‐Berberich, Luitgard Nagel‐Steger, Matthias Epple, Wolfgang Meyer‐Zaika, Anselm H. C. Horn, Heinrich Sticht, Sharmistha Sinha, Gal Bitan, Thomas H. Schrader · 2011 · Journal of the American Chemical Society
47. Nanomaterial applications for neurological diseases and central nervous system injury
    Lijie Huang, Jiangnan Hu, Shengwei Huang, Brian Zhiyang Wang, Felix Siaw-Debrah, Mark Kusah Nyanzu, Yu Zhang, Qichuan Zhuge · 2017 · Progress in Neurobiology
48. Selenoprotein P and selenoprotein M block Zn2+-mediated Aβ42 aggregation and toxicity
    Xiubo Du, Haiping Li, Zhi Wang, Shi Qiu, Qiong Liu, Jiazuan Ni · 2013 · Metallomics
49. Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives
    Kyle J. Korshavn, Milim Jang, Yeon Ju Kwak, Akiko Kochi, Silvia Vertuani, Anirban Bhunia, Stefano Manfredini, Ayyalusamy Ramamoorthy, Mi Hee Lim · 2015 · Scientific Reports
50. Structural Basis of β‐Amyloid‐Dependent Synaptic Dysfunctions
    Christian Haupt, Jörg Leppert, Raik Rönicke, Jessica Meinhardt, Jay Kant Yadav, Ramadurai Ramachandran, Oliver Ohlenschläger, Klaus G. Reymann, Matthias Görlach, Marcus Fändrich · 2012 · Angewandte Chemie International Edition
51. Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators
    François Bischoff, Didier Berthelot, Michel A.J. De Cleyn, Gregor J. Macdonald, Garrett Minne, Daniel Oehlrich, Serge Pieters, Michel Surkyn, Andrés A. Trabanco, Gary Tresadern et al. · 2012 · Journal of Medicinal Chemistry
52. Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease
    Rong Sheng, Li Tang, Liu Jiang, Lingjuan Hong, Ying Shi, Naiming Zhou, Yongzhou Hu · 2015 · ACS Chemical Neuroscience
53. Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease
    Ying Cao, Ling Wang, Ge Hu, Xi Lin Lu, Zhong Pei, Qiong Gu, Jun Xu · 2013 · Molecular Diversity
54. Synthesis and Biological Evaluation of Clicked Curcumin and Clicked KLVFFA Conjugates as Inhibitors of β-Amyloid Fibril Formation
    Myriam M. Ouberai, Pascal Dumy, Sabine Chierici, Julian Garcia · 2009 · Bioconjugate Chemistry
55. Role of Surface Charge of Inhibitors on Amyloid Beta Fibrillation
    S. Swathi, Pandurangan Kalipillai, Poornima Budime Santhosh, Ethayaraja Mani · 2017 · The Journal of Physical Chemistry C
56. Organoplatinum‐Substituted Polyoxometalate Inhibits β‐amyloid Aggregation for Alzheimer's Therapy
    Jing Wei Zhao, Kexin Li, Kaiwei Wan, Tiedong Sun, Nannan Zheng, Fanjiao Zhu, Jichao Ma, Jia Jiao, Tianchan Li, Jinyuan Ni et al. · 2019 · Angewandte Chemie International Edition
57. Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates
    Elisabet Viayna, Tània Gómez, Carles Galdeano, Lorena Ramírez, Míriam Ratia, Albert Badı́a, M. Victòria Clos, Ester Verdaguer, Fèlix Junyent, Antoni Camins et al. · 2010 · ChemMedChem
58. Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in 64Cu PET Imaging for Alzheimer’s Disease
    Anuj K. Sharma, Jason W. Schultz, John T. Prior, Nigam P. Rath, Liviu M. Mirica · 2017 · Inorganic Chemistry
59. An N-Heterocyclic Amine Chelate Capable of Antioxidant Capacity and Amyloid Disaggregation
    Kimberly M. Lincoln, Timothy E. Richardson, Lauren Rutter, Paulina Gonzalez, James W. Simpkins, Kayla N. Green · 2012 · ACS Chemical Neuroscience
60. Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function
    Sunil Kumar, Anja Henning‐Knechtel, Mazin M. Magzoub, Andrew D. Hamilton · 2018 · Journal of the American Chemical Society
61. Brain ageing and neurodegenerative disease: The role of cellular waste management
    Simona Daniele, Chiara Giacomelli, Claudia Martini · 2018 · Biochemical Pharmacology
62. Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer’s Disease Mutation
    Xueyun Zheng, Deyu Liu, Robin Roychaudhuri, David B. Teplow, Michael T. Bowers · 2015 · ACS Chemical Neuroscience
63. Differentiating Aβ40 and Aβ42 in amyloid plaques with a small molecule fluorescence probe
    Jing Yang, Biyue Zhu, Wei Hua Yin, Zhihao Han, Chao Zheng, Peng Wang, Chongzhao Ran · 2020 · Chemical Science
64. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
    Jose Luis Marco, Óscar M. Bautista‐Aguilera, Gerard Esteban, Mourad Chioua, Katarina M. Nikolic, Danica Agbaba, Ignacio Moraleda, Isabel Iriepa, Elena Soriano, Abdelouahid Samadi et al. · 2014 · Drug Design Development and Therapy
65. Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β
    Alaina S. DeToma, Janarthanan Krishnamoorthy, Younwoo Nam, Hyuck Jin Lee, Jeffrey Brender, Akiko Kochi, Dongkuk Lee, Valentina Onnis, Cenzo Congiu, Stefano Manfredini et al. · 2014 · Chemical Science
66. Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease
    Fan Li, Jia‐Jia Wu, Jin Wang, Xuelian Yang, Pei Cai, Qiaohong Liu, Ling‐Yi Kong, Xiaobing Wang · 2017 · Bioorganic & Medicinal Chemistry
67. A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation
    Luiza Moreira Gomes, Atif Mahammed, Kathleen E. Prosser, Jason R. Smith, Michael A. Silverman, Charles J. Walsby, Zeev Gross, Tim Storr · 2018 · Chemical Science
68. Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease
    Wei Xu, Xiaobing Wang, Zhi-Min Wang, Jia‐Jia Wu, Fan Li, Jin Wang, Ling‐Yi Kong · 2016 · MedChemComm
69. Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease
    Chunli Xia, Gui‐Hua Tang, Yan‐Qiong Guo, You‐Kai Xu, Zhi‐Shu Huang, Sheng Yin · 2018 · Phytochemistry
70. Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015–Present: Synthesis and Biological Activity
    Todd J. Eckroat, Danielle L. Manross, Seth C. Cowan · 2020 · International Journal of Molecular Sciences
71. Inhibition of metal-induced amyloid aggregation using light-responsive magnetic nanoparticle prochelator conjugates
    Meng Li, Zhen Liu, Jinsong Ren, Xiaogang Qu · 2011 · Chemical Science
72. Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity
    Ting Wang, Yuan‐Jian Yang, Pengfei Wu, Wei Wang, Zhuang‐Li Hu, Li‐Hong Long, Na Xie, Hui Qun Fu, Fang Wang, Jianguo Chen · 2010 · European Journal of Pharmacology
73. Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property
    Zhikun Liu, Lei Fang, Huan Zhang, Shaohua Gou, Li Chen · 2017 · Bioorganic & Medicinal Chemistry
74. MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation
    Binglin Zhu, Yan Long, Wei Luo, Zhen Yan, Yujie Lai, Lige Zhao, Weihui Zhou, Yan‐Jiang Wang, Lin‐Lin Shen, Lu Liu et al. · 2018 · Brain
75. Targeted brain delivery of RVG29‐modified rifampicin‐loaded nanoparticles for Alzheimer's disease treatment and diagnosis
    Ruiyi Zhou, Lihong Zhu, Zhaohao Zeng, Rixin Luo, Jiawei Zhang, Li Deng, Rui Guo, Qunying Zhang, Qunying Zhang, Wei Bi · 2022 · Bioengineering & Translational Medicine
76. Neuritogenic Militarinone‐Inspired 4‐Hydroxypyridones Target the Stress Pathway Kinase MAP4K4
    Peter Schröder, Tim Förster, Stefan Kleine, C.J. Becker, André Richters, Slava Ziegler, Daniel Rauh, Kamal Kumar, Herbert Waldmann · 2015 · Angewandte Chemie International Edition
77. Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons
    Janis Noonan, Riffat Tanveer, Allan M. Klompas, Aoife Gowran, Joanne McKiernan, Veronica A. Campbell · 2010 · Journal of Biological Chemistry
78. Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology
    Sarah Schemmert, Elena Schartmann, Christian Zafiu, Bettina Kass, Sonja Hartwig, Stefan Lehr, Oliver Bannach, Karl‐Josef Langen, Nadim Jon Shah, Janine Kutzsche et al. · 2018 · Molecular Neurobiology
79. Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi‐ and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β‐Amyloid (Aβ) Aggregation
    Michele Tonelli, Marco Catto, Bruno Tasso, Federica Novelli, Caterina Canu, G. Iusco, Leonardo Pisani, Angelo De Stradis, Nunzio Denora, Anna Sparatore et al. · 2015 · ChemMedChem
80. Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease
    Steven H. Liang, Adam G. Southon, Benjamin H. Fraser, Anwen M. Krause‐Heuer, Bo Zhang, Timothy M. Shoup, Rebecca Lewis, Irene Volitakis, Yifeng Han, Ivan D. Greguric et al. · 2015 · ACS Medicinal Chemistry Letters
81. Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
    Julien Lalut, Gianluca Santoni, Delphine Karila, Cédric Lecoutey, Audrey Davis, Florian Nachon, Israel Silman, Joel L. Sussman, Martin Weik, Tangui Maurice et al. · 2018 · European Journal of Medicinal Chemistry
82. A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease
    Masha G. Savelieff, Yuzhong Liu, Russell R.P. Senthamarai, Kyle J. Korshavn, Hyuck Jin Lee, Ayyalusamy Ramamoorthy, Mi Hee Lim · 2013 · Chemical Communications
83. Multifunctional iron-chelators with protective roles against neurodegenerative diseases
    A.C.C. Nunes, Sérgio M. Marques, Catarina Quintanova, Diana Filipa Silva, Sandra M. Cardoso, Sı́lvia Chaves, Maria Amélia Santos · 2013 · Dalton Transactions
84. A resorcinarene for inhibition of Aβ fibrillation
    Xu Han, Jiyong Park, Wei Wu, Andrés Malagón, Lingyu Wang, Édgar F. Vargas, Athula H. Wikramanayake, Kendall N. Houk, Roger M. Leblanc · 2016 · Chemical Science
85. Estrogen-related receptor alpha is involved in Alzheimer's disease-like pathology
    Ying Tang, Zhuo Min, Xiaojiao Xiang, Lu Liu, Yuanlin Ma, Binglin Zhu, Song Li, Jing Tang, Xiaojuan Deng, Zhen Yan et al. · 2018 · Experimental Neurology
86. Versatile fluorescent probes for near-infrared imaging of amyloid-β species in Alzheimer's disease mouse model
    Chao Peng, Xueli Wang, Yinhui Li, Hung‐Wing Li, Man Shing Wong · 2019 · Journal of Materials Chemistry B
87. Recent Development of Bifunctional Small Molecules to Study Metal‐Amyloid‐β Species in Alzheimer′s Disease
    Braymer, Joseph J., DeToma, Alaina S., Choi, Jung-Suk, Ko, Kristin S., Lim, Mi Hee · 2011 · International Journal of Alzheimer’s Disease
88. A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation
    Akiko Kochi, Todd J. Eckroat, Keith D. Green, Abdelrahman S. Mayhoub, Mi Hee Lim, Sylvie Garneau‐Tsodikova · 2013 · Chemical Science
89. From BACE1 Inhibitor to Multifunctionality of Tryptoline and Tryptamine Triazole Derivatives for Alzheimer’s Disease
    Jutamas Jiaranaikulwanitch, Piyarat Govitrapong, Valery V. Fokin, Opa Vajragupta · 2012 · Molecules
90. Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides
    Chao Ma, Juanjuan Su, Yao Sun, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang et al. · 2019 · Angewandte Chemie International Edition
91. Intercommunication between metal ions and amyloidogenic peptides or proteins in protein misfolding disorders
    Jong‐Min Suh, Mingeun Kim, Jeasang Yoo, Jiyeon Han, Cinthya Paulina, Mi Hee Lim · 2022 · Coordination Chemistry Reviews
92. microRNAs: A connection between cholesterol metabolism and neurodegeneration
    Leigh Goedeke, Carlos F Fernandez-Hernando · 2014 · Neurobiology of Disease
93. Activity of Selected Group of Monoterpenes in Alzheimer’s Disease Symptoms in Experimental Model Studies—A Non-Systematic Review
    Karolina A. Wojtunik‐Kulesza, Monika Rudkowska, Kamila Kasprzak‐Drozd, Anna Oniszczuk, Kinga K. Borowicz · 2021 · International Journal of Molecular Sciences
94. Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity
    Sharma, Anuj K., Kim, Jaekwang, Prior, John T., Hawco, Nicholas J., Rath, Nigam P., Kim, Jungsu, Mirica, Liviu M. · 2014 · Inorganic Chemistry
95. Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors
    Jaroslav Šebestı́k, Sérgio M. Marques, Pedro L. V. Fale, Susana Santos, Daniela M. Arduíno, Sandra M. Cardoso, Catarina Resende Oliveira, Maria Luísa Serralheiro, Maria Amélia Santos · 2010 · Journal of Enzyme Inhibition and Medicinal Chemistry
96. Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor
    Hitoshi Endo, Yuri Nikaido, Mamiko Nakadate, Satomi Ise, Hiroyuki Konno · 2014 · Bioorganic & Medicinal Chemistry Letters
97. Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease
    Jaspreet Kalra, Aamir Ghafoor Khan · 2015 · European Journal of Pharmacology
98. Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase
    Haibin Shi, Kai Liu, Ashley Xu, Shao Qin Yao · 2009 · Chemical Communications
99. Ferulic acid–carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents
    Lei Fang, Mohao Chen, Zhikun Liu, Xubin Fang, Shaohua Gou, Li Chen · 2016 · Bioorganic & Medicinal Chemistry
100. Chemical Probes for Visualizing Intact Animal and Human Brain Tissue
     H. M. Lai, Wai‐Lung Ng, Steve Gentleman, Wutian Wu · 2017 · Cell chemical biology