Cited by 663Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesDementia and Cognitive Impairment Research

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Alzheimer's Disease: From Pathology to Therapeutic Approaches

Jakob‐Roetne, Roland, Jacobsen, Helmut·2009·Angewandte Chemie International Edition

DOI 10.1002/anie.200802808

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Abstract

Mind how you go: The current strategies for the development of therapies for Alzheimer's disease are very diverse. Particular attention is given to the search for inhibitors (see picture for two examples) of the proteolytic enzyme beta- and gamma-secretase, which inhibits the cleavage of the amyloid precursor proteins into amyloid beta peptides, from which the disease-defining deposits of plaque in the brains of Alzheimer's patients originates.Research on senile dementia and Alzheimer's disease covers an extremely broad range of scientific activities. At the recent international meeting of the Alzheimer's Association (ICAD 2008, Chicago) more than 2200 individual scientific contributions were presented. The aim of this Review is to give an overview of the field and to outline its main areas, starting from behavioral abnormalities and visible pathological findings and then focusing on the molecular details of the pathology. The "amyloid hypothesis" of Alzheimer's disease is given particular attention, since the majority of the ongoing therapeutic approaches are based on its theoretical framework.

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References
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BindingDB Entry 50008097: Novel multi target-directed ligands targeting 5-HT
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Authors: Jakob‐Roetne, R., & Jacobsen, H.
Affiliations: F. Hoffmann-La Roche AG (CH)
Corresponding author: Jakob‐Roetne, Roland
Jacobsen, Helmut
ORCID: Jacobsen, Helmut
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2009-04-07
Volume: 48
Issue: 17
Pages: 3030-3059
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.200802808
OpenAlex: W2065100984
Cited by: 626
References: 314
Citations by year: 2026: 21 · 2025: 19 · 2024: 27 · 2023: 26 · 2022: 39 · 2021: 27 · 2020: 38 · 2019: 37 · 2018: 39 · 2017: 49 · 2016: 40 · 2015: 52 · 2014: 45 · 2013: 45 · 2012: 43
FWCI: 4.61
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, amyloid hypothesis, beta-secretase inhibitors, gamma-secretase inhibitors, amyloid precursor protein, amyloid-beta, amyloid plaques, behavioral abnormalities, Alzheimer's disease pathology, Alzheimer's disease therapeutics
MeSH terms: Alzheimer Disease, Amyloid, Humans, Protease Inhibitors, Amyloid Precursor Protein Secretases, Drug Discovery

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Alzheimer's Disease: From Pathology to Therapeutic Approaches

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