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A Switchable Biocompatible Polymer Surface with Self‐Sterilizing and Nonfouling Capabilities
Abstract
Trap, kill, and release: An antimicrobial cationic surface can effectively kill bacterial cells and switch to a nonfouling zwitterionic surface which releases dead microorganisms upon hydrolysis (see picture). This biocompatible nonfouling surface can prevent further attachment of proteins and microorganisms and the formation of a biofilm on the surface.
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“However, the susceptibility of PEG to oxidative damage, especially in the presence of O2, transition metal ions or certain enzymes in vivo, has limited its long-term application in complex media.59,60”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [59]
In the citing paper
“Jiang and coworkers developed a cationic poly(N,N-dimethyl-N-(ethoxycarbonylmethyl)-N-[2’-(methacryloyloxy)ethyl]-ammonium bromide) that has a quaternary ammonium group and was grafted onto a gold surface by surface-initiated atom transfer radical polymerization.59”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [59]
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Blackman, L. D., Fros, M. K., Welch, N. G., Gengenbach, T. R., Qu, Y., Pasic, P. J., Gunatillake, P. A., Thissen, H. W., Cass, P., & Locock, K. E. S. (2020) · Macromolecular Materials and Engineering · doi:10.1002/mame.202000371 · Cited by 8
Rahim, M. I., Doll, K., Stumpp, N. S., Eisenburger, M., & Stiesch, M. (2021) · Advanced Materials Interfaces · doi:10.1002/admi.202101410 · Cited by 8
Biofilm Instigation of Plant Pathogenic Bacteria and Its Control Measures
Antony, A. R., Janani, R., & Kannan, V. R. (2017) · doi:10.1002/9781119246329.ch21 · Cited by 8
Metadata
- Authors
- Cheng, G., Xue, H., Zhang, Z., Chen, S., & Jiang, S.
- Affiliations
- University of Washington (US)
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-10-28
- Volume
- 47
- Issue
- 46
- Pages
- 8831-8834
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2043772624
- Cited by
- 371
- References
- 28
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 11 · 2023: 15 · 2022: 31 · 2021: 24 · 2020: 24 · 2019: 27 · 2018: 26 · 2017: 30 · 2016: 35 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 11
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Keywords
- cationic surfaces, zwitterionic surfaces, self-sterilization, non-fouling surfaces, biofilm inhibition, protein adsorption, hydrolysis, biomaterials
- MeSH terms
- Anti-Bacterial Agents, Biocompatible Materials, Escherichia coli, Fibrinogen, Polymers, Surface Properties, Surface Plasmon Resonance, Microbial Viability
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