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A Switchable Biocompatible Polymer Surface with Self‐Sterilizing and Nonfouling Capabilities
Abstract
Trap, kill, and release: An antimicrobial cationic surface can effectively kill bacterial cells and switch to a nonfouling zwitterionic surface which releases dead microorganisms upon hydrolysis (see picture). This biocompatible nonfouling surface can prevent further attachment of proteins and microorganisms and the formation of a biofilm on the surface.
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“However, the susceptibility of PEG to oxidative damage, especially in the presence of O2, transition metal ions or certain enzymes in vivo, has limited its long-term application in complex media.59,60”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [59]
In the citing paper
“Jiang and coworkers developed a cationic poly(N,N-dimethyl-N-(ethoxycarbonylmethyl)-N-[2’-(methacryloyloxy)ethyl]-ammonium bromide) that has a quaternary ammonium group and was grafted onto a gold surface by surface-initiated atom transfer radical polymerization.59”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [59]
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Metadata
- Authors
- Cheng, G., Xue, H., Zhang, Z., Chen, S., & Jiang, S.
- Affiliations
- University of Washington (US)
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-10-28
- Volume
- 47
- Issue
- 46
- Pages
- 8831-8834
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2043772624
- Cited by
- 371
- References
- 28
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 11 · 2023: 15 · 2022: 31 · 2021: 24 · 2020: 24 · 2019: 27 · 2018: 26 · 2017: 30 · 2016: 35 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 11
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Keywords
- cationic surfaces, zwitterionic surfaces, self-sterilization, non-fouling surfaces, biofilm inhibition, protein adsorption, hydrolysis, biomaterials
- MeSH terms
- Anti-Bacterial Agents, Biocompatible Materials, Escherichia coli, Fibrinogen, Polymers, Surface Properties, Surface Plasmon Resonance, Microbial Viability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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