The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction
Open accessAbstract
Throwing tumors a left-hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror-image phage display identified a high-affinity D-peptide ligand of MDM2 (see structure) that could be developed into a potent and protease-resistant p53 activator with potential antitumor activity.
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Shi, W., Wang, T., Yang, Z., Ren, Y., Han, D., Zheng, Y., Deng, X., Tang, S., & Zheng, J. (2024) · Angewandte Chemie · doi:10.1002/ange.202313640 · Cited by 1
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An Enzyme‐Cleavable Solubilizing‐Tag Facilitates the Chemical Synthesis of Mirror‐Image Proteins
Zheng, Y., Zhang, B., Shi, W., Deng, X., Wang, T., Han, D., Ren, Y., Yang, Z., Zhou, Y., Kuang, J., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202318897
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Protein-protein interaction inhibitors in cancer
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Protein–protein interaction inhibitors in the human proteome: lessons from 117 targeted interactions
Hyde, E., & Beekman, A. M. (2026) · RSC Medicinal Chemistry · doi:10.1039/d6md00552g
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BindingDB (2017) · UC San Diego · doi:10.7270/q2668g28
BindingDB (2019) · UC San Diego · doi:10.7270/q2571f44
BindingDB Entry 50040300: An ultrahigh affinity d-peptide antagonist Of MDM2.
BindingDB (2013) · UC San Diego · doi:10.7270/q20p1143
Metadata
- Authors
- Liu, M., Pazgier, M., Li, C., Yuan, W., Li, C., & Lu, W.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Lu, Wuyuan
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-05-06
- Volume
- 49
- Issue
- 21
- Pages
- 3649-3652
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC3359147
- OpenAlex
- W2107850581
- Cited by
- 115
- References
- 31
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 11 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 061482, AI-072732, R01AI072732, R01AI061482)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- p53-MDM2 interaction, MDM2, p53 activation, peptide inhibitors, protease resistance, tumor suppressor, cancer therapy, protein-protein interaction inhibition
- MeSH terms
- Amino Acid Sequence, Enzyme Inhibitors, Humans, Ligands, Molecular Sequence Data, Peptides, Stereoisomerism, Drug Design, Proto-Oncogene Proteins c-mdm2
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