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A Microgel Construction Kit for Bioorthogonal Encapsulation and pH‐Controlled Release of Living Cells
Abstract
pH‐Cleavable cell‐laden microgels with excellent long‐term viabilities were fabricated by combining bioorthogonal strain‐promoted azide–alkyne cycloaddition (SPAAC) and droplet‐based microfluidics. Poly(ethylene glycol)dicyclooctyne and dendritic poly(glycerol azide) served as bioinert hydrogel precursors. Azide conjugation was performed using different substituted acid‐labile benzacetal linkers that allowed precise control of the microgel degradation kinetics in the interesting pH range between 4.5 and 7.4. By this means, a pH‐controlled release of the encapsulated cells was achieved upon demand with no effect on cell viability and spreading. As a result, the microgel particles can be used for temporary cell encapsulation, allowing the cells to be studied and manipulated during the encapsulation and then be isolated and harvested by decomposition of the microgel scaffolds.
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Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Photoreversible Patterning of Biomolecules within Click‐Based Hydrogels
DeForest, C. A., & Anseth, K. S. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201106463 · Cited by 315
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Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering
Xue, X., Hu, Y., Deng, Y., & Su, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009432 · Cited by 532
Mao, A. S., Shin, J.-W., Utech, S., Wang, H., Uzun, O., Li, W., Cooper, M., Hu, Y., Zhang, L., Weitz, D. A., et al. (2017) · Nature Materials · doi:10.1038/nmat4781 · Cited by 371
Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications
Zhang, X., Malhotra, S., Molina, M., & Haag, R. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00341a · Cited by 364
Self-citationEngineered modular biomaterial logic gates for environmentally triggered therapeutic delivery
Badeau, B. A., Comerford, M. P., Arakawa, C. K., Shadish, J. A., & DeForest, C. A. (2018) · Nature Chemistry · doi:10.1038/nchem.2917 · Cited by 292
Metadata
- Authors
- Steinhilber, D., Rossow, T., Wedepohl, S., Paulus, F., Seiffert, S., & Haag, R.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2013-11-29
- Volume
- 52
- Issue
- 51
- Pages
- 13538-13543
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2163455313
- Cited by
- 164
- References
- 2
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Steinhilber, D., Rossow, T., Wedepohl, S., Paulus, F., Seiffert, S., & Haag, R. (2013). A Microgel Construction Kit for Bioorthogonal Encapsulation and pH‐Controlled Release of Living Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201308005
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