The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery
Open accessAbstract
The successful transport of drug- and cell-based therapeutics to diseased sites represents a major barrier in the development of clinical therapies. Targeted delivery can be mediated through degradable biomaterial vehicles that utilize disease biomarkers to trigger payload release. Here, we report a modular chemical framework for imparting hydrogels with precise degradative responsiveness by using multiple environmental cues to trigger reactions that operate user-programmable Boolean logic. By specifying the molecular architecture and connectivity of orthogonal stimuli-labile moieties within material crosslinkers, we show selective control over gel dissolution and therapeutic delivery. To illustrate the versatility of this methodology, we synthesized seventeen distinct stimuli-responsive materials that collectively yielded all possible YES/OR/AND logical outputs from input combinations involving enzyme, reductant, and light. Using these hydrogels we demonstrate the first sequential and environmentally stimulated release of multiple cell lines in well-defined combinations from a material. We expect these platforms will find utility in several diverse fields including drug delivery, diagnostics, and regenerative medicine.
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Cites
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A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
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Hersh, A. M., Alomari, S., & Tyler, B. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084153 · Cited by 478
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Polymer Networks: From Plastics and Gels to Porous Frameworks
Gu, Y., Zhao, J., & Johnson, J. A. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201902900 · Cited by 388
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Metadata
- Authors
- Badeau, B. A., Comerford, M. P., Arakawa, C. K., Shadish, J. A., & DeForest, C. A.
- Venue
- Nature Chemistry
- Published
- 2018-01-15
- Volume
- 10
- Issue
- 3
- Pages
- 251-258
- ISSN
- 1755-4330 (ISSN-L)
- 1755-4349
- OpenAlex
- W2782940950
- Cited by
- 292
- References
- 39
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Badeau, B. A., Comerford, M. P., Arakawa, C. K., Shadish, J. A., & DeForest, C. A. (2018). Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery. Nature Chemistry. https://doi.org/10.1038/nchem.2917
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
