The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hypoxia‐Targeted siRNA Delivery
Open accessAbstract
Altered vasculature and the resultant chaotic tumor blood flow lead to the appearance in fast‐growing tumors of regions with gradients of oxygen tension and acute hypoxia (less than 1.4 % oxygen).1 Due to its roles in tumorigenesis and resistance to therapy, hypoxia represents a problem in cancer therapy.1, 2 Insufficient delivery of therapeutic agents to the hypoxic regions in solid tumors is recognized as one of the causes of resistance to therapy.1, 3 This led to the development of hypoxia imaging agents,4 and the use of hypoxia‐activated anticancer prodrugs.2a Here we show the first example of the hypoxia‐induced siRNA uptake and silencing using a nanocarrier consisting of polyethyleneglycol 2000, azobenzene, polyethyleneimine (PEI)(1.8 kDa), and 1,2‐dioleyl‐sn‐glycero‐3‐phosphoethanolamine (DOPE) units (the nanocarrier is referred to as PAPD), where azobenzene imparts hypoxia sensitivity and specificity.4a We report hypoxia‐activated green fluorescent protein (GFP) silencing in vitro and its downregulation in GFP‐expressing tumors after intravenous administration. The proposed nanoformulation represents a novel tumor‐environment‐responsive modality for cancer targeting and siRNA delivery.
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Cites
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Exploiting tumour hypoxia in cancer treatment
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Layer-by-Layer Nanoparticles with a pH-Sheddable Layer for in Vivo Targeting of Tumor Hypoxia
Poon, Z., Chang, D., Zhao, X., & Hammond, P. T. (2011) · ACS Nano · doi:10.1021/nn200876f · Cited by 343
In vivo delivery of RNAi with lipid-based nanoparticles
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Cited by
Block copolymer micelles in nanomedicine applications
Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309
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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics
Mi, P. (2020) · Theranostics · doi:10.7150/thno.38069 · Cited by 830
Zhang, C., Zhao, K., Bu, W., Ni, D., Liu, Y., Feng, J., & Shi, J. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201408472 · Cited by 516
Multifunctional polymeric micelles for delivery of drugs and siRNA
Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466
Self-citation
Metadata
- Authors
- Perche, F., Biswas, S., Wang, T., Zhu, L., & Torchilin, V. P.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-02-19
- Volume
- 53
- Issue
- 13
- Pages
- 3362-3366
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2161036292
- Cited by
- 234
- References
- 7
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- green
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