The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting
Abstract
In protein‐rich environments such as the blood, the formation of a protein corona on receptor‐targeting nanoparticles prevents target recognition. As a result, the ability of targeted nanoparticles to selectively bind to diseased cells is drastically inhibited. Backfilling the surface of a targeted nanoparticle with polyethylene glycol (PEG) molecules is demonstrated to reduce the formation of the protein corona and re‐establishes specific binding. The length of the backfilled PEG molecules must be less than the length of the ligand linker; otherwise, PEG interferes with the binding of the targeting ligand to its corresponding cellular receptor.
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Self-citationTrastuzumab — Mechanism of Action and Use in Clinical Practice
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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology
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Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719
Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors
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Self-citationComplement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Chen, F., Wang, G., Griffin, J. I., Brenneman, B., Banda, N. K., Holers, V. M., Backos, D. S., Wu, L., Moghimi, S. M., & Simberg, D. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.269 · Cited by 599
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Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., Prise, K. M., Golding, J., & Mason, N. J. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0021-x · Cited by 445
Cloaking nanoparticles with protein corona shield for targeted drug delivery.
Oh, J. Y., Kim, H. S., Palanikumar, L., Go, E. M., Jana, B., Park, S. A., Kim, H. Y., Kim, K., Seo, J. K., Kwak, S. K., et al. (2018) · Nature communications · doi:10.1038/s41467-018-06979-4 · Cited by 409
Metadata
- Authors
- Dai, Q., Walkey, C., & Chan, W. C. W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-04-02
- Volume
- 53
- Issue
- 20
- Pages
- 5093-5096
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2119550206
- Cited by
- 371
- References
- 32
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dai, Q., Walkey, C., & Chan, W. C. W. (2014). Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201309464
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