The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery
Open accessAbstract
The discovery and implementation of antibiotics in the early twentieth century transformed human health and wellbeing. Chemical synthesis enabled the development of the first antibacterial substances, organoarsenicals and sulfa drugs, but these were soon outshone by a host of more powerful and vastly more complex antibiotics from nature: penicillin, streptomycin, tetracycline, and erythromycin, among others. These primary defences are now significantly less effective as an unavoidable consequence of rapid evolution of resistance within pathogenic bacteria, made worse by widespread misuse of antibiotics. For decades medicinal chemists replenished the arsenal of antibiotics by semisynthetic and to a lesser degree fully synthetic routes, but economic factors have led to a subsidence of this effort, which places society on the precipice of a disaster. We believe that the strategic application of modern chemical synthesis to antibacterial drug discovery must play a critical role if a crisis of global proportions is to be averted.
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Cites
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Tang, S., & Zheng, J. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701503 · Cited by 1,205
Natural Products as Platforms To Overcome Antibiotic Resistance
Rossiter, S. E., Fletcher, M. H., & Wuest, W. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00283 · Cited by 622
Bauer, R. A. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.05.005 · Cited by 534
Drugging Membrane Protein Interactions
Yin, H., & Flynn, A. D. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092115-025322 · Cited by 339
The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs
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Metadata
- Authors
- Wright, P. M., Seiple, I. B., & Myers, A. G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-07-02
- Volume
- 53
- Issue
- 34
- Pages
- 8840-8869
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2138298207
- Cited by
- 426
- References
- 10
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wright, P. M., Seiple, I. B., & Myers, A. G. (2014). The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201310843
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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