The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering
Open accessAbstract
Glucose is a ubiquitous energy source for most living organisms. Its uptake activity closely reflects cellular metabolic demand in various physiopathological conditions. Extensive efforts have been made to specifically image glucose uptake, such as with positron emission tomography, magnetic resonance imaging, and fluorescence microscopy, but all have limitations. A new platform to visualize glucose uptake activity in live cells and tissues is presented that involves performing stimulated Raman scattering on a novel glucose analogue labeled with a small alkyne moiety. Cancer cells with differing metabolic activities can be distinguished. Heterogeneous uptake patterns are observed with clear cell–cell variations in tumor xenograft tissues, neuronal culture, and mouse brain tissues. By offering the distinct advantage of optical resolution but without the undesirable influence of fluorophores, this method will facilitate the study of energy demands of living systems with subcellular resolution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Toward a Glucose Biosensor Based on Surface-Enhanced Raman Scattering
Shafer-Peltier, K. E., Haynes, C. L., Glucksberg, M. R., & Van Duyne, R. P. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028255v · Cited by 653
In vivo imaging of glucose uptake and metabolism in tumors
Walker-Samuel, S., Ramasawmy, R., Torrealdea, F., Rega, M., Rajkumar, V., Johnson, S. P., Richardson, S., Gonçalves, M., Parkes, H. G., Årstad, E., et al. (2013) · Nature Medicine · doi:10.1038/nm.3252 · Cited by 479
Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
Yamakoshi, H., Dodo, K., Palonpon, A., Ando, J., Fujita, K., Kawata, S., & Sodeoka, M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308529n · Cited by 461
Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
Yamakoshi, H., Dodo, K., Okada, M., Ando, J., Palonpon, A., Fujita, K., Kawata, S., & Sodeoka, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108404p · Cited by 356
Cited by
Biological imaging of chemical bonds by stimulated Raman scattering microscopy
Hu, F., Shi, L., & Min, W. (2019) · Nature Methods · doi:10.1038/s41592-019-0538-0 · Cited by 392
Self-citationHu, F., Lamprecht, M. R., Wei, L., Morrison, B., & Min, W. (2016) · Scientific Reports · doi:10.1038/srep39660 · Cited by 367
Self-citationStimulated Raman Scattering: From Bulk to Nano
Prince, R. C., Frontiera, R. R., & Potma, E. O. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00545 · Cited by 350
Stimulated Raman scattering microscopy: an emerging tool for drug discovery
Tipping, W. J., Lee, M., Serrels, A., Brunton, V. G., & Hulme, A. N. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00693g · Cited by 266
Metadata
- Authors
- Hu, F., Chen, Z., Zhang, L., Shen, Y., Wei, L., & Min, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-07-16
- Volume
- 54
- Issue
- 34
- Pages
- 9821-9825
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2161568165
- Cited by
- 164
- References
- 4
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering. https://app.cochat.ai/papers/10.1002/anie.201502543
- The paper
- Hu, F., Chen, Z., Zhang, L., Shen, Y., Wei, L., & Min, W. (2015). Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201502543
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
