Stimulated Raman Scattering: From Bulk to Nano
Open accessAbstract
Stimulated Raman scattering (SRS) describes a family of techniques first discovered and developed in the 1960s. Whereas the nascent history of the technique is parallel to that of laser light sources, recent advances have spurred a resurgence in its use and development that has spanned across scientific fields and spatial scales. SRS is a nonlinear technique that probes the same vibrational modes of molecules that are seen in spontaneous Raman scattering. While spontaneous Raman scattering is an incoherent technique, SRS is a coherent process, and this fact provides several advantages over conventional Raman techniques, among which are much stronger signals and the ability to time-resolve the vibrational motions. Technological improvements in pulse generation and detection strategies have allowed SRS to probe increasingly smaller volumes and shorter time scales. This has enabled SRS research to move from its original domain, of probing bulk media, to imaging biological tissues and single cells at the micro scale, and, ultimately, to characterizing samples with subdiffraction resolution at the nanoscale. In this Review, we give an overview of the history of the technique, outline its basic properties, and present historical and current uses at multiple length scales to underline the utility of SRS to the molecular sciences.
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Flagged first, then by citations
Research works printed but not linked: 4
- [5]Ng WK Woodbury EJ Ruby Laser Operation in Near IR Proc. Inst. Radio Eng 1962 50 2367
- [68]Boyd RW Nonlinear Optics 2003 Burlington Academic Press
- [70]Potma EO Mukamel S Cheng J-X Xie XS Coherent Raman Scattering Microscopy 2013 Baton Rouge, LA CRC Press
- [199]Wang P Slipchenko MN Mitchell J Yang C Potma EO Xu X Cheng J-X Far-Field Imaging of Non-Fluorescent Species with Subdiffraction Resolution Nat. Photonics 2013 7 449 453 24436725 PMC3891596
Cited by
Sorted by citations
Rapid single-particle chemical imaging of nanoplastics by SRS microscopy
Qian, N., Gao, X., Lang, X., Deng, H., Bratu, T. M., Chen, Q., Stapleton, P., Yan, B., & Min, W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300582121 · Cited by 467 · see citing works
Biological imaging of chemical bonds by stimulated Raman scattering microscopy
Hu, F., Shi, L., & Min, W. (2019) · Nature Methods · doi:10.1038/s41592-019-0538-0 · Cited by 392 · see citing works
- Authors
- Prince, R. C., Frontiera, R. R., & Potma, E. O.
- Affiliations
- University of California, Irvine (US)
- University of Minnesota (US)
- Corresponding author
- Potma, Eric O.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-12-14
- Volume
- 117
- Issue
- 7
- Pages
- 5070-5094
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC5471143
- OpenAlex
- W2563293115
- Cited by
- 350
- References
- 209
- Citations by year
- 2026: 44 · 2025: 52 · 2024: 49 · 2023: 41 · 2022: 38 · 2021: 31 · 2020: 31 · 2019: 31 · 2018: 24 · 2017: 9
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Division of Chemistry (CHE-1414466, CHE-1552849)
- National Center for Research Resources (P41-RR01192)
- Division of Graduate Education (DGE-1144901)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Laser-Matter Interactions and Applications
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Spectroscopy and Quantum Chemical Studies
- Keywords
- stimulated Raman scattering, nonlinear optics, vibrational spectroscopy, coherent Raman scattering, sub-diffraction resolution, nanoscale imaging, single-cell imaging, tissue imaging, laser pulse generation
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