The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Emerging Targets in Photopharmacology
Open accessAbstract
The field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provides a viable alternative to optogenetics. We present here a critical overview of the different pharmacological targets in various organs and a survey of organ systems in the human body that can be addressed in a non‐invasive manner. We discuss the prospects for the selective delivery of light to these organs and the specific requirements for light‐activatable drugs. We also aim to illustrate the druggability of medicinal targets with recent findings and emphasize where conceptually new approaches have to be explored to provide photopharmacology with future opportunities to bring “smart” molecular design ultimately to the realm of clinical use.
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Cites
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The development and application of optogenetics
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G Protein–Coupled Receptor Rhodopsin
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Cited by
Advances and opportunities in the exciting world of azobenzenes
Jerca, F. A., Jerca, V. V., & Hoogenboom, R. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00334-w · Cited by 522
Molecular photoswitches in aqueous environments
Volarić, J., Szymanski, W., Simeth, N. A., & Feringa, B. L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00547a · Cited by 438
Self-citationRecent Implementations of Molecular Photoswitches into Smart Materials and Biological Systems
Pianowski, Z. L. (2019) · Chemistry – A European Journal · doi:10.1002/chem.201805814 · Cited by 328
Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications
Xu, Y., Tang, Y., & Li, Q. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202416359 · Cited by 49
Metadata
- Authors
- Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymanski, W., & Feringa, B. L.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-07-04
- Volume
- 55
- Issue
- 37
- Pages
- 10978-10999
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2469713039
- Cited by
- 675
- References
- 11
- FWCI
- 29.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymanski, W., & Feringa, B. L. (2016). Emerging Targets in Photopharmacology. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201601931
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
