The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy
Abstract
Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)‐assisted conversion of glucose into gluconic acid and toxic H 2 O 2, a novel treatment paradigm of starving‐like therapy is developed for significant tumor‐killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H 2 O 2 can oxidize l‐Arginine (l‐Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co‐delivery of GOx and l‐Arg, a novel glucose‐responsive nanomedicine (l‐Arg‐HMON‐GOx) has been for the first time constructed for synergistic cancer starving‐like/gas therapy without the need of external excitation, which yields a remarkable H 2 O 2–NO cooperative anticancer effect with minimal adverse effect.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D. S., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,769
The metabolism of tumors in the body
Warburg, O., Wind, F., & Negelein, E. (1927) · Journal of General Physiology · doi:10.1085/jgp.8.6.519 · Cited by 4,416
Production of large amounts of hydrogen peroxide by human tumor cells.
Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,526
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science · doi:10.1126/science.2834821 · Cited by 1,555
Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., Ligler, F. S., Buse, J. B., & Gu, Z. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505405112 · Cited by 848
Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody
Wang, C., Ye, Y., Hochu, G. M., Sadeghifar, H., & Gu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b05030 · Cited by 784
Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy
López-Lázaro, M. (2007) · Cancer Letters · doi:10.1016/j.canlet.2006.10.029 · Cited by 715
Fan, W., Bu, W., Shen, B., He, Q., Cui, Z., Liu, Y., Zheng, X., Zhao, K., & Shi, J. (2015) · Advanced Materials · doi:10.1002/adma.201405141 · Cited by 665
Self-citationChen, Y., Meng, Q., Wu, M., Wang, S., Xu, P., Chen, H., Li, Y., Zhang, L., Wang, L., & Shi, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja508721y · Cited by 374
Self-citationChen, Y., & Shi, J. (2016) · Advanced Materials · doi:10.1002/adma.201505147 · Cited by 356
Cited by
Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202006892 · Cited by 820
Self-citationNanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Lin, H., Chen, Y., & Shi, J. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00471k · Cited by 803
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy
Fu, L., Qi, C., Hu, Y., Lin, J., & Huang, P. (2019) · Advanced Materials · doi:10.1002/adma.201808325 · Cited by 600
Self-citationCroissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Metadata
- Authors
- Fan, W., Lu, N., Huang, P., Liu, Y., Yang, Z., Wang, S., Yu, G., Liu, Y., Hu, J., He, Q., Qu, J., Wang, T., & Chen, X.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-12-09
- Volume
- 56
- Issue
- 5
- Pages
- 1229-1233
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2560756484
- Cited by
- 640
- References
- 32
- FWCI
- 20.21
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy. https://app.cochat.ai/papers/10.1002/anie.201610682
- The paper
- Fan, W., Lu, N., Huang, P., Liu, Y., Yang, Z., Wang, S., Yu, G., Liu, Y., Hu, J., He, Q., Qu, J., Wang, T., & Chen, X. (2017). Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201610682
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
