The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody
Open accessAbstract
Despite recent advances in melanoma treatment through the use of anti-PD-1 (aPD1) immunotherapy, the efficacy of this method remains to be improved. Here we report an innovative self-degradable microneedle (MN) patch for the sustained delivery of aPD1 in a physiologically controllable manner. The microneedle is composed of biocompatible hyaluronic acid integrated with pH-sensitive dextran nanoparticles (NPs) that encapsulate aPD1 and glucose oxidase (GOx), which converts blood glucose to gluconic acid. The generation of acidic environment promotes the self-dissociation of NPs and subsequently results in the substantial release of aPD1. We find that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. Moreover, this administration strategy can integrate with other immunomodulators (such as anti-CTLA-4) to achieve combination therapy for enhancing antitumor efficacy.
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Cites
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Stimuli-responsive polymers and their applications
Wei, M., Gao, Y., Li, X., & Serpe, M. J. (2017) · Polymer Chemistry · doi:10.1039/c6py01585a · Cited by 1,298
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Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818
Biomedicine Meets Fenton Chemistry
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Metadata
- Authors
- Wang, C., Ye, Y., Hochu, G. M., Sadeghifar, H., & Gu, Z.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-03-24
- Volume
- 16
- Issue
- 4
- Pages
- 2334-2340
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2308809093
- Cited by
- 784
- References
- 10
- FWCI
- 34.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, C., Ye, Y., Hochu, G. M., Sadeghifar, H., & Gu, Z. (2016). Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody. Nano Letters. https://doi.org/10.1021/acs.nanolett.5b05030
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