The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model
Abstract
Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn 3 O 4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology‐dependent. The redox modulatory effect of Mn 3 O 4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)‐like cellular model, indicating that manganese‐based nanomaterials having multi‐enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS‐mediated neurological disorders.
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Cites
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Cited by
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Metal‐Nitrogen‐Doped Carbon Materials as Highly Efficient Catalysts: Progress and Rational Design
Shi, Z., Yang, W., Gu, Y., Liao, T., & Sun, Z. (2020) · Advanced Science · doi:10.1002/advs.202001069 · Cited by 470
Nanozymes: Activity origin, catalytic mechanism, and biological application
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Magnetic Nanostructures: Rational Design and Fabrication Strategies toward Diverse Applications
Wang, S., Xu, J., Li, W., Sun, S., Gao, S., & Hou, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00370 · Cited by 129
Metadata
- Authors
- Singh, N., Savanur, M. A., Srivastava, S., D'Silva, P., & Mugesh, G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-10-04
- Volume
- 56
- Issue
- 45
- Pages
- 14267-14271
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2756282825
- Cited by
- 657
- References
- 8
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Singh, N., Savanur, M. A., Srivastava, S., D'Silva, P., & Mugesh, G. (2017). A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201708573
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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