The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A Size‐Reducible Nanodrug with an Aggregation‐Enhanced Photodynamic Effect for Deep Chemo‐Photodynamic Therapy
Abstract
Fluorescent dyes with multi‐functionality are of great interest for photo‐based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self‐assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye‐chemodrug conjugate. The self‐assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Φ(1 O 2)). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved in situ tumor imaging and potent tumor inhibition by deep chemo‐PDT. Our work verifies a facile and effective self‐assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.
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Cites
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
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Precise nanomedicine for intelligent therapy of cancer
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Metadata
- Authors
- Ji, C., Gao, Q., Dong, X., Yin, W., Gu, Z., Gan, Z., Zhao, Y., & Yin, M.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-08
- Volume
- 57
- Issue
- 35
- Pages
- 11384-11388
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2884902032
- Cited by
- 258
- References
- 44
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ji, C., Gao, Q., Dong, X., Yin, W., Gu, Z., Gan, Z., Zhao, Y., & Yin, M. (2018). A Size‐Reducible Nanodrug with an Aggregation‐Enhanced Photodynamic Effect for Deep Chemo‐Photodynamic Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201807602
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