The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Metal–Organic Framework (MOF) Hybrid as a Tandem Catalyst for Enhanced Therapy against Hypoxic Tumor Cells
Abstract
Encapsulation of active biomolecules and/or nanoparticles in metal–organic frameworks (MOFs) remains a great challenge in biomedical applications. In this work, through a stepwise in situ growth method, a black phosphorus quantum dot (BQ) and catalase were precisely encapsulated into the inner and outer layers of MOFs, respectively. The integrated MOF system as a tandem catalyst could convert H 2 O 2 into O 2 in MOF‐stabilized catalase outer layer, and then O 2 was directly injected into MOF‐sensitized BQ inner, leading to high quantum yield of singlet oxygen. Upon internalization, the photodynamic therapy efficiency of the MOF system was 8.7‐fold greater than that without catalase, showing an enhanced therapeutic effect against hypoxic tumor cells. Furthermore, by coupling with photothermal therapy of BQs, photodynamic‐thermal synergistic therapy was realized both in vitro and in vivo.
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Cites
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Cited by
Wang, S., Zheng, H., Zhou, L., Cheng, F., Liu, Z., Zhang, H., Wang, L., & Zhang, Q. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c01371 · Cited by 573
Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Ma, L., Jiang, F., Fan, X., Wang, L., He, C., Zhou, M., Li, S., Luo, H., Cheng, C., & Qiu, L. (2020) · Advanced Materials · doi:10.1002/adma.202003065 · Cited by 298
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Self-citationGathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Metadata
- Authors
- Liu, J., Liu, T., Du, P., Zhang, L., & Lei, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-05-06
- Volume
- 58
- Issue
- 23
- Pages
- 7808-7812
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2936558625
- Cited by
- 192
- References
- 1
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, J., Liu, T., Du, P., Zhang, L., & Lei, J. (2019). Metal–Organic Framework (MOF) Hybrid as a Tandem Catalyst for Enhanced Therapy against Hypoxic Tumor Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201903475
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