The DOI matches its Crossref record; 65 of the 69 references it cites were found in a registry or an index.
In Situ Self‐Assembled Nanofibers Precisely Target Cancer‐Associated Fibroblasts for Improved Tumor Imaging
Abstract
Tumor complexity makes the development of highly sensitive tumor imaging probes an arduous task. Here, we construct a peptide‐based near‐infrared probe that is responsive to fibroblast activation protein‐α (FAP‐α), and specifically forms nanofibers on the surface of cancer‐associated fibroblasts (CAFs) in situ. The assembly/aggregation‐induced retention (AIR) effect results in enhanced accumulation and retention of the probe around the tumor, resulting in a 5.5‐fold signal enhancement in the tumor 48 h after administration compared to that of a control molecule that does not aggregate. The probe provides a prolonged detectable window of 48 h for tumor diagnosis. The selective assembly of the probe results in a signal intensity over four‐ and fivefold higher in tumor than in the liver and kidney, respectively. With enhanced tumor imaging capability, this probe can visualize small tumors around 2 mm in diameter.
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“J-aggregate nanomedicines possessing in situ self-assembly capabilities hold the potential to redefine tumor targeting modalities through the assembly/aggregation-induced retention effect240.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [240]
Citations
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Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Enzyme-Responsive Nanoparticles for Anti-tumor Drug Delivery
Li, M., Zhao, G., Su, W.-K., & Shuai, Q. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00647 · Cited by 253
In situ self-assembly for cancer therapy and imaging
Kim, J., Lee, S., Kim, Y., Choi, M., Lee, I., Kim, E., Yoon, C. G., Pu, K., Kang, H., & Kim, J. S. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00589-3 · Cited by 248
Smart drug delivery systems for precise cancer therapy
Wang, X., Li, C., Wang, Y., Chen, H., Zhang, X., Luo, C., Zhou, W., Li, L., Teng, L., Yu, H., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.08.013 · Cited by 256
Self-citationEnzymatic Noncovalent Synthesis
He, H., Tan, W., Guo, J., Yi, M., Shy, A. N., & Xu, B. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00306 · Cited by 225
Metadata
- Authors
- Zhao, X., Li, L., Zhao, Y., An, H., Cai, Q., Lang, J., Han, X., Peng, B., Fei, Y., Liu, H., Qin, H., Nie, G., & Wang, H.
- Affiliations
- CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) No. 11 Beiyitiao Zhongguancun Beijing 100190 China
- Chinese Academy of Sciences (CN)
- Corresponding author
- Nie, Guangjun
- Wang, Hao
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-09-12
- Volume
- 58
- Issue
- 43
- Pages
- 15287-15294
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2967302867
- Cited by
- 147
- References
- 69
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 16 · 2023: 33 · 2022: 31 · 2021: 22 · 2020: 20
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31671028, 51873045, 51725302, 51573032 and 11621505)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017053)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- cancer-associated fibroblasts, tumor imaging, fibroblast activation protein, peptide-based probe, self-assembled nanofibers, tumor targeting, small tumor detection, tumor microenvironment
- MeSH terms
- Cancer-Associated Fibroblasts, Fibroblast Activation Protein Alpha, Amino Acid Sequence, Animals, Fluorescent Dyes, Humans, Membrane Proteins, Mice, Nude, Microscopy, Electron, Scanning, Neoplasms, Endopeptidases, Peptides, Serine Endopeptidases, Tissue Distribution, Transplantation, Heterologous, Gelatinases, Coculture Techniques, Spectroscopy, Near-Infrared, Cell Line, Tumor, Mice, Nanofibers
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