Enzyme-Responsive Nanoparticles for Anti-tumor Drug Delivery
Open accessAbstract
The past few decades have seen great progress in the exploration of nanoparticles (NPs) as novel tools for cancer treatments and diagnosis. Practical and reliable application of nanoparticle-based technology in clinical transformation remains nevertheless an ongoing challenge. The design, preparation, and evaluation of various smart NPs with specific physicochemical responses in tumor-related physiological conditions have been of great interests in both academic and clinical research. Of particular, smart enzyme-responsive nanoparticles can predictively and selectively react with specific enzymes expressed in tumor tissues, leading to targeted delivery of anti-tumor drugs, reduced systemic toxicity, and improved therapeutic effect. In addition, NPs interact with internal enzymes usually under mild conditions (low temperature, aqueous media, neutral or close to neutral pH) with high efficiency. In this review, recent advances in the past 5 years in enzyme-responsive nanoparticles for anti-tumor drug delivery are summarized and discussed. The following contents are divided based on the different action sites of enzymes toward NPs, notably hydrophobic core, cleavable/uncleavable linker, hydrophilic crown, and targeting ligand. Enzyme-engaged destruction of any component of these delicate nanoparticle structures could result in either targeting drug delivery or controlled drug release.
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Smart nanoparticles can modify their form, structure, solubility, surface charge, self-association, or dissociation behaviors in response to internal and external stimuli, which can increase endosomal escape, promote cellular uptake, or cause payload release.
“Smart nanoparticles can modify their form, structure, solubility, surface charge, self-association, or dissociation behaviors in response to internal and external stimuli (Fig. 3), which can increase endosomal escape, promote cellular uptake, or cause payload release.133”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [133]
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Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444 · see citing works
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108 · see citing works
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070 · see citing works
Therapeutic Nanoparticles for Drug Delivery in Cancer
Cho, K., Wang, X., Nie, S., Chen, Z. (., & Shin, D. M. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1441 · Cited by 2,919 · see citing works
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic‐Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,734 · see citing works
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674 · see citing works
Ligand-targeted therapeutics in anticancer therapy
Allen, T. M. (2002) · Nature reviews. Cancer · doi:10.1038/nrc903 · Cited by 1,648 · see citing works
(1997) · PubMed · Cited by 1,541 · see citing works
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works
Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery
Cheng, R., Meng, F., Deng, C., Klok, H., & Zhong, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.084 · Cited by 1,356 · see citing works
Biodegradable nanoparticles for drug delivery and targeting
Hans, M. L., & Lowman, A. M. (2002) · Current Opinion in Solid State and Materials Science · doi:10.1016/s1359-0286(02)00117-1 · Cited by 1,324 · see citing works
Dennis, E. A., Cao, J., Hsu, Y., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,213 · see citing works
Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
Zhou, Q., Shao, S., Wang, J., Xu, C., Xiang, J., Piao, Y., Zhou, Z., Yu, Q., Tang, J., Liu, X., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0485-z · Cited by 822 · see citing works
Nanoparticles for drug delivery in cancer treatment
Haley, B., & Frenkel, E. P. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2007.03.015 · Cited by 805 · see citing works
Progress in Nanomedicine: Approved and Investigational Nanodrugs.
Ventola, C. L. (2017) · Europe PMC (PubMed Central) · Cited by 795 · see citing works
Enzyme-responsive nanoparticles for drug release and diagnostics
de la Rica, R., Aili, D., & Stevens, M. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.002 · Cited by 765 · cited 1× · see citing works
“Moreover, enzymes, as triggers, have many advantages, including high chemical selectivity and substrate specificity (de la Rica et al., 2012), and usually enzyme-catalyzed reactions proceed efficiently under mild conditions (low temperature, aqueous media, neutral or close to neutral pH) (Ulijn,…”
BackgroundEnzyme-responsive polymeric assemblies, nanoparticles and hydrogels
Hu, J., Zhang, G., & Liu, S. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35103j · Cited by 725 · see citing works
Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration
West, J. L., & Hubbell, J. A. (1998) · Macromolecules · doi:10.1021/ma981296k · Cited by 627 · see citing works
Super pH-Sensitive Multifunctional Polymeric Micelle
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Nano Letters · doi:10.1021/nl0479987 · Cited by 611 · see citing works
Li, J., Huo, M., Wang, J., Zhou, J., Mohammad, J. M., Zhang, Y., Zhu, Q., Waddad, A. Y., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.022 · Cited by 468 · see citing works
Enzyme-responsive materials: a new class of smart biomaterials
Ulijn, R. V. (2006) · Journal of Materials Chemistry · doi:10.1039/b601776m · Cited by 468 · see citing works
Cathepsin B: Multiple roles in cancer
Aggarwal, N., & Sloane, B. F. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300105 · Cited by 404 · see citing works
Lee, E. S., Gao, Z., Kim, D., Park, K., Kwon, I. C., & Bae, Y. H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.04.024 · Cited by 400 · see citing works
Smart Nanocarrier Based on PEGylated Hyaluronic Acid for Cancer Therapy
Choi, K. Y., Yoon, H. Y., Kim, J., Bae, S. M., Park, R., Kang, Y. M., Kim, I.-S., Kwon, I. C., Choi, K., Jeong, S. Y., et al. (2011) · ACS Nano · doi:10.1021/nn202070n · Cited by 398 · see citing works
Yang, G., Xu, L., Xu, J., Zhang, R., Song, G., Chao, Y., Feng, L., Han, F., Dong, Z., Li, B., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00040 · Cited by 398 · see citing works
Mannweiler, S., Amersdorfer, P., Trajanoski, S., Terrett, J. A., King, D., & Méhes, G. (2008) · Pathology & Oncology Research · doi:10.1007/s12253-008-9104-2 · Cited by 386 · see citing works
Trover, J. K., Beckett, M. L., & Wright, G. L. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910620511 · Cited by 374 · see citing works
Lee, S., Cha, E., Park, K., et al. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200705240 · Cited by 350 · see citing works
Roles of Matrix Metalloproteinases in Tumor Metastasis and Angiogenesis
Yoon, S.-O., Park, S.-J., Yun, C.-H., & Chung, A. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.1.128 · Cited by 320 · see citing works
Ko, J.-Y., Park, K., Kim, Y.-S., Kim, M.-S., Han, J. K., Kim, K., Park, R., Kim, I.-S., Song, H. K., Lee, D. S., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.07.012 · Cited by 303 · see citing works
Thermosensitive polymer-modified liposomes
Kono, K. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00204-6 · Cited by 303 · see citing works
Min, K. H., Kim, J.-H., Bae, S. M., Shin, H., Kim, M.-S., Park, S.-J., Lee, H., Park, R., Kim, I.-S., Kim, K., et al. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.024 · Cited by 287 · see citing works
Targeted Therapies for Cancer 2004
Ross, J. S., Schenkein, D. P., Pietrusko, R. G., Rolfe, M., Linette, G. P., Stec, J. J., Stagliano, N. E., Ginsburg, G. S., Symmans, W. F., Pusztai, L., et al. (2004) · American Journal of Clinical Pathology · doi:10.1309/5cwpu41afr1vym3f · Cited by 286 · see citing works
Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation
Ruan, S., Hu, C., Tang, X., Cun, X., Xiao, W., Shi, K., He, Q., & Gao, H. (2016) · ACS Nano · doi:10.1021/acsnano.6b05070 · Cited by 263 · see citing works
Therapeutic Enzyme‐Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors
Callmann, C. E., Barback, C. V., Thompson, M. P., Hall, D. J., Mattrey, R. F., & Gianneschi, N. C. (2015) · Advanced Materials · doi:10.1002/adma.201501803 · Cited by 249 · see citing works
Prostate-specific Membrane Antigen–radioguided Surgery for Metastatic Lymph Nodes in Prostate Cancer
Maurer, T., Weirich, G., Schottelius, M., et al. (2015) · European Urology · doi:10.1016/j.eururo.2015.04.034 · Cited by 233 · see citing works
Li, L., ten Hagen, T. L. M., Hossann, M., Süss, R., van Rhoon, G. C., Eggermont, A. M. M., Haemmerich, D., & Koning, G. A. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.011 · Cited by 211 · see citing works
Yáng, Z., Dai, Y., Yin, C., Fan, Q., Zhang, W., Song, J., Yu, G., Tang, W., Fan, W., Yung, B. C., et al. (2018) · Advanced Materials · doi:10.1002/adma.201707509 · Cited by 208 · see citing works
In situ diselenide-crosslinked polymeric micelles for ROS-mediated anticancer drug delivery
Deepagan, V. G., Kwon, S., You, D. G., Nguyen, V. Q., Um, W., Ko, H., Lee, H., Jo, D., Kang, Y. M., & Park, J. H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.044 · Cited by 195 · see citing works
Shi, C., Guo, X., Qu, Q., Tang, Z., Wang, Y., & Zhou, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.036 · Cited by 189 · see citing works
van Rijt, S., Bölükbas, D. A., Argyo, C., Datz, S., Lindner, M., Eickelberg, O., Königshoff, M., Bein, T., & Meiners, S. (2015) · ACS Nano · doi:10.1021/nn5070343 · Cited by 188 · see citing works
Han, H., Valdepérez, D., Jin, Q., Yang, B., Li, Z., Wu, Y., Pelaz, B., Parak, W. J., & Ji, J. (2017) · ACS Nano · doi:10.1021/acsnano.6b05541 · Cited by 186 · see citing works
A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells
Zhang, M., Xu, C., Wen, L., Han, M. K., Xiao, B., Zhou, J., Zhang, Y., Zhang, Z., Viennois, É., & Merlin, D. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1681 · Cited by 172 · see citing works
Lin, Q., Bao, C., Yang, Y., Liang, Q.-N., Zhang, D., Cheng, S., & Zhu, L. (2013) · Advanced Materials · doi:10.1002/adma.201204455 · Cited by 163 · see citing works
Hu, Q., Sun, W., Lü, Y., Bomba, H. N., Ye, Y., Jiang, T., Isaacson, A., & Gu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b04343 · Cited by 162 · see citing works
Zhang, N., Zhao, F., Zou, Q., Li, Y., Ma, G., & Yan, X. (2016) · Small · doi:10.1002/smll.201602339 · Cited by 161 · see citing works
Wang, C., Chen, S., Wang, Y., Liu, X., Hu, F., Sun, J., & Yuan, H. (2018) · Advanced Materials · doi:10.1002/adma.201706407 · Cited by 159 · see citing works
Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo
Lee, S., Ryu, J. H., Park, K., Lee, A., Lee, S. Y., 윤인찬, Ahn, C.-H., Yoon, S. M., Myung, S., Moon, D. H., et al. (2009) · Nano Letters · doi:10.1021/nl902709m · Cited by 156 · see citing works
Liu, Y., Zhang, D., Qiao, Z., Qi, G., Liang, X., Chen, X., & Wang, H. (2015) · Advanced Materials · doi:10.1002/adma.201501502 · Cited by 155 · see citing works
Hou, B., Zhou, L., Wang, H., Saeed, M., Wang, D., Xu, Z., Li, Y., & Yu, H. (2020) · Advanced Materials · doi:10.1002/adma.201907210 · Cited by 152 · see citing works
Subdiaphragmatic and intrathoracic paraspinal malignant peripheral nerve sheath tumors
Kourea, H. P., Bilsky, M. H., Leung, D. H. Y., Lewis, J. J., & Woodruff, J. M. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980601)82:11 · Cited by 149 · see citing works
Zhao, X., Li, L., Zhao, Y., An, H., Cai, Q., Lang, J., Han, X., Peng, B., Fei, Y., Liu, H., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908185 · Cited by 147 · see citing works
Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy
Han, L., Liu, C., Qi, H., Zhou, J., Wen, J., Wu, D., Xu, D., Qin, M., Ren, J., Wang, Q., et al. (2019) · Advanced Materials · doi:10.1002/adma.201805697 · Cited by 145 · see citing works
Chen, X., Gao, H., Deng, Y., Jin, Q., Ji, J., & Ding, D. (2020) · ACS Nano · doi:10.1021/acsnano.0c02197 · Cited by 142 · see citing works
Peng, J., Yang, Q., Xiao, Y., Shi, K., Liu, Q., Hao, Y., Yang, F., Han, R., & Qian, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900004 · Cited by 139 · see citing works
van Dijk, M., van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2010) · Biomacromolecules · doi:10.1021/bm1002637 · Cited by 130 · see citing works
Kim, H., Kim, Y., Kim, I.-H., Kim, K., & Choi, Y. (2014) · Theranostics · doi:10.7150/thno.7101 · Cited by 127 · see citing works
Yu, Q., Qiu, Y., Li, J., Tang, X., Wang, X., Cun, X., Xu, S., Liu, Y., Li, M., Zhang, Z., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.040 · Cited by 119 · see citing works
Self-citationHan, H. S., Choi, K. Y., Lee, H., Lee, M., An, J. Y., Shin, S., Kwon, S., Lee, D. S., & Park, J. H. (2016) · ACS Nano · doi:10.1021/acsnano.6b05113 · Cited by 107 · see citing works
Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs
Choi, K. Y., Silvestre, O. F., Huang, X., Min, K. H., Howard, G. P., Hida, N., Jin, A. J., Carvajal, N., Lee, S. W., Hong, J.-I., et al. (2014) · ACS Nano · doi:10.1021/nn500085k · Cited by 104 · see citing works
Resistance to epidermal growth factor receptor-targeted therapy
Morgillo, F., & Lee, H. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2005.08.004 · Cited by 96 · see citing works
Drug delivery and release systems for targeted tumor therapy
Böhme, D., & Beck‐Sickinger, A. G. (2015) · Journal of Peptide Science · doi:10.1002/psc.2753 · Cited by 94 · see citing works
Tang, S., Meng, Q., Sun, H., Su, J., Yin, Q., Zhang, Z., Yu, H., Chen, L., Chen, Y., Gu, W., et al. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601703 · Cited by 94 · see citing works
Enzyme‐Responsive Delivery of Multiple Proteins with Spatiotemporal Control
Zhu, S., Nih, L. R., Carmichael, S. T., Lu, Y., & Segura, T. (2015) · Advanced Materials · doi:10.1002/adma.201500417 · Cited by 86 · see citing works
Xu, J., Han, W., Cheng, Z., Yang, P., Bi, H., Yang, D., Niu, N., He, F., Gai, S., & Lin, J. (2018) · Chemical Science · doi:10.1039/c7sc05414a · Cited by 85 · see citing works
Xu, C., Yu, Y., Sun, Y., Kong, L., Yang, C., Hu, M. Y., Yang, T., Zhang, J., Hu, Q., & Zhang, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905213 · Cited by 84 · see citing works
Ihsanullah, K. M., Kumar, B. N., Zhao, Y., Hassan, M., Liu, Y., Wang, L., Liu, H., & Jiang, W. J. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119982 · Cited by 67 · see citing works
Ding, J., Liang, T., Zhou, Y., He, Z., Min, Q., Jiang, L., & Zhu, J. (2016) · Nano Research · doi:10.1007/s12274-016-1328-y · Cited by 64 · see citing works
Gayam, S. R., Venkatesan, P., Sung, Y.-M., Sung, S.-Y., Hu, S., Hsu, H., & Wu, S. (2016) · Nanoscale · doi:10.1039/c6nr03525f · Cited by 63 · see citing works
Limmer, S., Hahn, J., Schmidt, R., Wachholz, K., Zengerle, A., Lechner, K., Eibl, H., Issels, R. D., Hossann, M., & Lindner, L. H. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1322-6 · Cited by 60 · see citing works
Yang, Y., Yue, C., Han, Y., Zhang, W., He, A., Zhang, C., Yin, T., Zhang, Q., Zhang, J., Yang, Y., et al. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601369 · Cited by 58 · see citing works
Lee, J., Oh, E., Yoon, H., Kim, C. W., Han, Y., Song, J., Jang, H., Park, H. J., & Kim, C. (2017) · Nanoscale · doi:10.1039/c7nr00808b · Cited by 58 · see citing works
Activatable Protein Nanoparticles for Targeted Delivery of Therapeutic Peptides
Yu, X., Gou, X., Wu, P., Han, L., Tian, D., Du, F., Chen, Z., Liu, F., Deng, G., Chen, A. T., et al. (2018) · Advanced Materials · doi:10.1002/adma.201705383 · Cited by 57 · see citing works
Zhang, L., Qi, Y., Min, H., Ni, C., Wang, F., Wang, B., Qin, H., Zhang, Y., Liu, G., Qin, Y., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b08142 · Cited by 56 · see citing works
pH‐Sensitive Nanoflash for Tumoral Acidic pH Imaging in Live Animals
Ko, J. Y., Park, S., Lee, H., et al. (2010) · Small · doi:10.1002/smll.201001252 · Cited by 55 · see citing works
Son, J., Kalafatović, D., Kumar, M., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b07401 · Cited by 50 · see citing works
MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy
Wang, Z., Wang, Y., Jia, X., Han, Q., Qian, Y., Li, Q., Xiang, J., Wang, Q., Hu, Z., & Wang, W. (2019) · Theranostics · doi:10.7150/thno.30915 · Cited by 48 · see citing works
Poveda, A. M., Pousa, A. L., Martín‐Broto, J., et al. (2005) · Sarcoma · doi:10.1080/13577140500287024 · Cited by 37 · see citing works
Li, S., Chen, L., Huang, K., Chen, N., Zhan, Q., Yi, K., Qi, H., Liu, C., Tan, Y., Hou, X., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201903296 · Cited by 28 · see citing works
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Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561 · see citing works
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Recent advances in targeted drug delivery systems for resistant colorectal cancer
Sharifi-Azad, M., Fathi, M., Cho, W. C., Barzegari, A., Dadashi, H., Dadashpour, M., & Jahanban-Esfahlan, R. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02605-y · Cited by 65 · see citing works
- Authors
- Li, M., Zhao, G., Su, W.-K., & Shuai, Q.
- Affiliations
- Zhejiang University of Technology (CN)
- Corresponding author
- Shuai, Qi
- Venue
- Frontiers in Chemistry
- Publisher
- Frontiers Media SA
- Published
- 2020-07-30
- Volume
- 8
- Pages
- 647-647
- ISSN
- 2296-2646 (ISSN-L)
- PMC
- PMC7406800
- OpenAlex
- W3046481824
- Cited by
- 253
- References
- 80
- Citations by year
- 2026: 57 · 2025: 80 · 2024: 36 · 2023: 34 · 2022: 30 · 2021: 13 · 2020: 3
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- enzyme-responsive nanoparticles, smart nanoparticles, anticancer drug delivery, targeted drug delivery, controlled drug release, cleavable linkers, hydrophobic core, targeting ligands, cancer therapeutics
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