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Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Abstract
Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small Δ EST, 4TPA‐BQ shows a satisfactorily high 1 O 2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.
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Metadata
- Authors
- Li, Q., Li, Y., Min, T., Gong, J., Du, L., Phillips, D. L., Liu, J., Lam, J. W. Y., Sung, H. H. Y., Williams, I. D., Kwok, R. T. K., Ho, C. L., Li, K., Wang, J., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- University of Hong Kong (HK)
- Inner Mongolia University (CN)
- Corresponding author
- Wang, Jianguo
- Tang, Ben Zhong
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-10-22
- Volume
- 59
- Issue
- 24
- Pages
- 9470-9477
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2976022258
- Cited by
- 211
- References
- 58
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 27 · 2023: 27 · 2022: 60 · 2021: 33 · 2020: 29
- FWCI
- 22.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- aggregation-induced emission, photosensitizers, photodynamic therapy, singlet oxygen generation, antibacterial activity, ampicillin-resistant Escherichia coli, cancer cell ablation, reactive oxygen species
- MeSH terms
- A549 Cells, Animals, Chlorocebus aethiops, Escherichia coli, Humans, Photochemotherapy, Photosensitizing Agents, COS Cells, Ablation Techniques, Molecular Targeted Therapy
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