The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Abstract
Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA‐BQ, by a one‐step reaction. 4TPA‐BQ presents aggregation‐induced emission features. Owing to the aggregation‐induced reactive oxygen species generated and a sufficiently small Δ EST, 4TPA‐BQ shows a satisfactorily high 1 O 2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA‐BQ exhibited potent photodynamic antibacterial performance against ampicillin‐resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time‐dependent fluorescence‐guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA‐BQ reveals new design principles for the implementation of efficient PSs in clinical applications.
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Siegel, R. L., Miller, K. D., & Jemal, A. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21551 · Cited by 20,160
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
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Self-citationAggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationHighly efficient organic light-emitting diodes from delayed fluorescence
Uoyama, H., Goushi, K., Shizu, K., Nomura, H., & Adachi, C. (2012) · Nature · doi:10.1038/nature11687 · Cited by 8,219
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Activatable Photosensitizers for Imaging and Therapy
Lovell, J. F., Liu, T. W. B., Chen, J., & Zheng, G. (2010) · Chemical Reviews · doi:10.1021/cr900236h · Cited by 1,718
Klymchenko, A. S. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00517 · Cited by 1,228
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Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Wang, M., Zhang, G., Zhang, D., Zhu, D., & Tang, B. Z. (2010) · Journal of Materials Chemistry · doi:10.1039/b921610c · Cited by 855
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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Aggregation‐Induced Emission: New Vistas at the Aggregate Level
Zhao, Z., Zhang, H., Lam, J. W. Y., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201916729 · Cited by 1,442
Self-citationDesign of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 809
Aggregate Science: From Structures to Properties
Zhang, H., Zhao, Z., Turley, A. T., Wang, L., McGonigal, P. R., Tu, Y., Li, Y., Wang, Z., Kwok, R. T. K., Lam, J. W. Y., et al. (2020) · Advanced Materials · doi:10.1002/adma.202001457 · Cited by 528
Self-citationAggregation-Induced Emission (AIE), Life and Health
Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 404
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Metadata
- Authors
- Li, Q., Li, Y., Min, T., Gong, J., Du, L., Phillips, D. L., Liu, J., Lam, J. W. Y., Sung, H. H. Y., Williams, I. D., Kwok, R. T. K., Ho, C. L., Li, K., Wang, J., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- University of Hong Kong (HK)
- Inner Mongolia University (CN)
- Corresponding author
- Wang, Jianguo
- Tang, Ben Zhong
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-10-22
- Volume
- 59
- Issue
- 24
- Pages
- 9470-9477
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2976022258
- Cited by
- 211
- References
- 58
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 27 · 2023: 27 · 2022: 60 · 2021: 33 · 2020: 29
- FWCI
- 22.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- aggregation-induced emission, photosensitizers, photodynamic therapy, singlet oxygen generation, antibacterial activity, ampicillin-resistant Escherichia coli, cancer cell ablation, reactive oxygen species
- MeSH terms
- A549 Cells, Animals, Chlorocebus aethiops, Escherichia coli, Humans, Photochemotherapy, Photosensitizing Agents, COS Cells, Ablation Techniques, Molecular Targeted Therapy
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