The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Smart Design of Nanomaterials for Mitochondria‐Targeted Nanotherapeutics
Abstract
Mitochondria are the powerhouse of cells. They are vital organelles that maintain cellular function and metabolism. Dysfunction of mitochondria results in various diseases with a great diversity of clinical appearances. In the past, strategies have been developed for fabricating subcellular‐targeting drug‐delivery nanocarriers, enabling cellular internalization and subsequent organelle localization. Of late, innovative strategies have emerged for the smart design of multifunctional nanocarriers. Hierarchical targeting enables nanocarriers to evade and overcome various barriers encountered upon in vivo administration to reach the organelle with good bioavailability. Stimuli‐responsive nanocarriers allow controlled release of therapeutics to occur at the desired target site. Synergistic therapy can be achieved using a combination of approaches such as chemotherapy, gene and phototherapy. In this Review, we survey the field for recent developments and strategies used in the smart design of nanocarriers for mitochondria‐targeted therapeutics. Existing challenges and unexplored therapeutic opportunities are also highlighted and discussed to inspire the next generation of mitochondrial‐targeting nanotherapeutics.
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Cites
Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404
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Tailoring nanocarriers for intracellular protein delivery
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Repairing mitochondrial dysfunction in disease
Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104908 · Cited by 337
Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents
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Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies
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Trackable Mitochondria-Targeting Nanomicellar Loaded with Doxorubicin for Overcoming Drug Resistance
Zhang, Y., Zhang, C., Chen, J., Liu, L., Hu, M., Li, J., & Bi, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b07219 · Cited by 109
Cited by
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Qian, L., Lin, X., Gao, X., Khan, R. U., Liao, J.-Y., Du, S., Ge, J., Zeng, S., & Yao, S. Q. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00915 · Cited by 155
Self-citationNakamura, T., Sato, Y., Yamada, Y., Abd Elwakil, M. M., Kimura, S., Younis, M. A., & Harashima, H. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114417 · Cited by 121
Wang, J., Zhao, Z., Liu, Y., Cao, X., Li, F., Ran, H., Cao, Y., & Wu, C. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2126027 · Cited by 34
Metadata
- Authors
- Liew, S. S., Qin, X., Zhou, J., Li, L., Huang, W., & Yao, S. Q.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-09-24
- Volume
- 60
- Issue
- 5
- Pages
- 2232-2256
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3041925007
- Cited by
- 286
- References
- 7
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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