The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer
Abstract
This study reports the development of iron‐chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging‐guided photothermal ferrotherapy of cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe 3+) and an amphiphilic semiconducting polycomplex (SP C) serving as both the photothermal nanotransducer and iron ion chelator. By virtue of poly(ethylene glycol) (PEG) grafting and its small size, SPFeN accumulates in the tumor of living mice after systemic administration, which can be monitored by PA imaging. In the acidic tumor microenvironment, SPFeN generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it generates localized heat to not only accelerate the Fenton reaction but also implement photothermal therapy. Such a combined photothermal ferrotherapeutic effect of SPFeN leads to minimized dosage of iron compared to previous studies and effectively inhibits the tumor growth in living mice, which is not possible for the controls.
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Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions
Tang, Z., Liu, Y., He, M., & Bu, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201805664 · Cited by 1,951
Zhang, C., Bu, W., Ni, D., Zhang, S., Li, Q., Yao, Z., Zhang, J., Yao, H., Wang, Z., & Shi, J. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510031 · Cited by 1,269
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Friedmann Angeli, J. P., Krysko, D. V., & Conrad, M. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,259
Drug Delivery with PEGylated MoS2 Nano‐sheets for Combined Photothermal and Chemotherapy of Cancer
Liu, T., Wang, C., Gu, X., Gong, H., Cheng, L., Shi, X., Feng, L., Sun, B., & Liu, Z. (2014) · Advanced Materials · doi:10.1002/adma.201305256 · Cited by 1,211
Water-Soluble Conjugated Polymers for Imaging, Diagnosis, and Therapy
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Li, J., & Pu, K. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,168
Self-citationThe development of the concept of ferroptosis
Hirschhorn, T., & Stockwell, B. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.043 · Cited by 1,052
Cited by
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941
Self-citationFerroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
Targeting ferroptosis opens new avenues for the development of novel therapeutics
Sun, S., Shen, J., Jiang, J., Wang, F., & Min, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01606-1 · Cited by 608
Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy
Zeng, Z., Zhang, C., Li, J., Cui, D., Jiang, Y., & Pu, K. (2021) · Advanced Materials · doi:10.1002/adma.202007247 · Cited by 276
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Metadata
- Authors
- He, S., Jiang, Y., Li, J., & Pu, K.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-04-20
- Volume
- 59
- Issue
- 26
- Pages
- 10633-10638
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3012907231
- Cited by
- 299
- References
- 65
- FWCI
- 17.03
- Type
- journal article
- Language
- en
- Open access
- closed
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