The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Ferroptosis Photoinduced by New Cyclometalated Iridium(III) Complexes and Its Synergism with Apoptosis in Tumor Cell Inhibition
Abstract
Limited therapeutic efficacy to hypoxic and refractory solid tumors has hindered the practical application of photodynamic therapy (PDT). Two new benzothiophenylisoquinoline (btiq)‐derived cyclometalated Ir III complexes, IrL1 and MitoIrL2, were constructed as potent photosensitizers, with the latter being designed for mitochondria accumulation. Both complexes demonstrated a type I PDT process and caused photoinduced ferroptosis in tumor cells under hypoxia. This ferroptosis featured lipid peroxide accumulation, mitochondria shrinkage, down‐regulation of glutathione peroxidase 4 (GPX4), and ferrostatin‐1 (Fer‐1)‐inhibited cell death. Upon photoirradiation under hypoxia, mitochondria targeting MitoIrL2 caused mitochondria membrane potential (MMP) collapse, ATP production suppression, and induced cell apoptosis. The synergetic effect of ferroptosis and apoptosis causes MitoIrL2 to outperform IrL1 in inhibiting the growth of MCF‐7, PANC‐1, MDA‐MB‐231 cells and multicellular spheroids. This study demonstrates the first example of ferroptosis induced by photosensitizing Ir III complexes. Moreover, the synergism of ferroptosis and apoptosis provides a promising approach for combating hypoxic solid tumors through type I PDT processes.
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Cites
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Cancer drug resistance: an evolving paradigm
Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681
Activation of apoptosis signalling pathways by reactive oxygen species
Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Phenotype and Genotype of Pancreatic Cancer Cell Lines
Deer, E. L., González-Hernández, J., Coursen, J. D., Shea, J. E., Ngatia, J., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181c15963 · Cited by 936
Cited by
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Ferroptosis promotes sonodynamic therapy: a platinum( ii )–indocyanine sonosensitizer
Lai, Y., Lu, N., Ouyang, A., Zhang, Q., & Zhang, P. (2022) · Chemical Science · doi:10.1039/d2sc02597c · Cited by 91
Metadata
- Authors
- Yuan, H., Han, Z., Chen, Y., Qi, F., Fang, H., Guo, Z., Zhang, S., & He, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-03-03
- Volume
- 60
- Issue
- 15
- Pages
- 8174-8181
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3134879255
- Cited by
- 282
- References
- 6
- FWCI
- 29.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuan, H., Han, Z., Chen, Y., Qi, F., Fang, H., Guo, Z., Zhang, S., & He, W. (2021). Ferroptosis Photoinduced by New Cyclometalated Iridium(III) Complexes and Its Synergism with Apoptosis in Tumor Cell Inhibition. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202014959
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