Ferroptosis promotes sonodynamic therapy: a platinum( ii )–indocyanine sonosensitizer

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

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Multifunctional materials for implantable and wearable photonic healthcare devices

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Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

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The Hallmarks of Ferroptosis

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Ultrafine Titanium Monoxide (TiO 1+ x ) Nanorods for Enhanced Sonodynamic Therapy

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Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWO X Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

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Ultrasound‐Activated Sensitizers and Applications

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Metal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy

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Hydrogen peroxide is the major oxidant product of xanthine oxidase

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Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

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Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

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Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy

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Ferroptosis Photoinduced by New Cyclometalated Iridium(III) Complexes and Its Synergism with Apoptosis in Tumor Cell Inhibition

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Newly developed strategies for improving sonodynamic therapy

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A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy

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Targeted delivery of platinum-based anticancer complexes

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Visible‐Light‐Induced Annihilation of Tumor Cells with Platinum–Porphyrin Conjugates

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A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

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NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

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Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy

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A self-assembled Ru–Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy

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An osmium-peroxo complex for photoactive therapy of hypoxic tumors

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Soluble Tetraarylporphyrin−Platinum Conjugates as Cytotoxic and Phototoxic Antitumor Agents

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A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near‐IR Light

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H2O2-Depleting and O2-Generating Selenium Nanoparticles for Fluorescence Imaging and Photodynamic Treatment of Proinflammatory-Activated Macrophages.

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Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy

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In Vitro Heavy-Atom Effect of Palladium(II) and Platinum(II) Complexes of Pyrrolidine-Fused Chlorin in Photodynamic Therapy

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Coordination-Driven Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism

Chan, L., Chen, X., Gao, P., Xie, J., Zhang, Z., Zhao, J., & Chen, T. (2021) · ACS Nano · doi:10.1021/acsnano.0c09454 · Cited by 79 · see citing works

Water-Soluble Iridic–Porphyrin Complex for Non-invasive Sonodynamic and Sono-oxidation Therapy of Deep Tumors

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Ultrasound-propelled Janus Au NR-mSiO2 nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors

Ye, J., Fu, Q., Liu, L., Chen, L., Zhang, X., Li, Q., Li, Z., Su, L., Zhu, R., Song, J., et al. (2021) · Science China Chemistry · doi:10.1007/s11426-021-1070-6 · Cited by 70 · see citing works

Triclocarban-induced responses of endogenous and xenobiotic metabolism in human hepatic cells: Toxicity assessment based on nontargeted metabolomics approach

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Biotinylated photoactive Pt( iv ) anticancer complexes

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Functional micro/nanobubbles for ultrasound medicine and visualizable guidance

Zhang, C., Li, Y., Ma, X., He, W., Liu, C., & Liu, Z. (2021) · Science China Chemistry · doi:10.1007/s11426-020-9945-4 · Cited by 37 · see citing works

A Platinum(II)‐based Photosensitive Tripod as an Effective Photodynamic Anticancer Agent through DNA Damage

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Stimuli-responsive ferroptosis for cancer therapy

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Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

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Mechanical stimuli-driven cancer therapeutics

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Xu, W., Guan, G., Yue, R., Dong, Z., Lei, L., Kang, H., & Song, G. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00546 · Cited by 98 · see citing works

Iridium(III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy

Zeng, Y., Liu, L., Ma, T., Liu, Y., Liu, B., Liu, W., Shen, Q., Wu, C., & Mao, Z. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202410803 · Cited by 78 · see citing works

Small molecule sonosensitizers in cancer therapy: recent advances and clinical prospects

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Nanotechnology-enabled sonodynamic therapy against malignant tumors

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Sonoinduced Tumor Therapy and Metastasis Inhibition by a Ruthenium Complex with Dual Action: Superoxide Anion Sensitization and Ligand Fracture

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Exosome‐Inhibiting Polymeric Sonosensitizer for Tumor‐Specific Sonodynamic Immunotherapy

Wu, J., Huang, J., Yu, J., Xu, M., Liu, J., & Pu, K. (2024) · Advanced Materials · doi:10.1002/adma.202400762 · Cited by 63 · see citing works

Evoking Ferroptosis by Synergistic Enhancement of a Cyclopentadienyl Iridium‐Betulin Immune Agonist

Lv, M., Zheng, Y., Wu, J., Shen, Z., Guo, B., Hu, G., Huang, Y., Zhao, J., Qian, Y., Su, Z. G., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202312897 · Cited by 59 · see citing works

Multimodal synergistic ferroptosis cancer therapy

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

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Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

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Ultrasound‐Activated Theranostic Materials and Their Bioapplications

Zhu, K., Wang, J., Wang, Z., Chen, Q., Song, J., & Chen, X. S. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202422278 · Cited by 49 · see citing works

Zn/Pt dual-site single-atom driven difunctional superimposition-augmented sonosensitizer for sonodynamic therapy boosted ferroptosis of cancer

Wen, D., Feng, J., Deng, R., Li, K., & Zhang, H. (2024) · Nature Communications · doi:10.1038/s41467-024-53488-8 · Cited by 48 · see citing works

Nanosensitizer-assisted sonodynamic therapy for breast cancer

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Current roles of metals in arming sonodynamic cancer therapy

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Comparative Study of Sonodynamic and Photoactivated Cancer Therapies with Re(I)-Tricarbonyl Complexes Comprising Phenanthroline Ligands

Kushwaha, R., Singh, V., Peters, S., Yadav, A. K., Sadhukhan, T., Koch, B., & Banerjee, S. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02485 · Cited by 38 · see citing works

Superoxide Dismutase‐Like Regulated Fe/Ppa@PDA/B for Synergistically Targeting Ferroptosis/Apoptosis to Enhance Anti‐Tumor Efficacy

Ding, X., Wang, Z., Yu, Q., Michał, N., Roman, S., Liu, Y., & Peng, N. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301824 · Cited by 37 · see citing works

An electron-accepting half-sandwich iridium( iii ) complex for the treatment of hypoxic tumors via synergetic chemo- and phototherapy

Yang, Y., Gao, Y., Zhao, J., & Gou, S. (2023) · Inorganic Chemistry Frontiers · doi:10.1039/d3qi02047a · Cited by 36 · see citing works

Metal Complexes for Cancer Sonodynamic Therapy

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Exploring BODIPY derivatives as sonosensitizers for anticancer sonodynamic therapy

Li, X., Sun, X., Chen, H., Chen, X., Li, Y., Li, D., Zhang, Z., Chen, H., & Gao, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116035 · Cited by 35 · see citing works

Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy

Wang, H., Lai, Y., Li, D., Karges, J., Zhang, P., & Huang, H. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01889 · Cited by 35 · see citing works

Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma

Wang, M., Guo, J., Yuan, S.-J., Li, K., Zhang, Q., Lei, H.-M., Wu, J.-L., Zhao, L., Xu, Y., & Chen, X. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122913 · Cited by 33 · see citing works

The advance of ultrasound-enabled diagnostics and therapeutics

Han, B., Liu, Y., Zhou, Q., Yu, Y., Liu, X., Guo, Y., Zheng, X., Zhou, M., Yu, H., & Wang, W. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.039 · Cited by 31 · see citing works

Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer

Wang, H., Li, D., Wang, H., Ren, Q., Pan, Y., Dao, A., Wang, D., Wang, Z., Zhang, P., & Huang, H. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01671 · Cited by 27 · see citing works

Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms

Li, Y., Wang, H., Lin, Q., Yu, X., Huang, H., & Zhang, P. (2023) · Science China Chemistry · doi:10.1007/s11426-023-1696-5 · Cited by 27 · see citing works

Advances in Nanodynamic Therapy for Cancer Treatment

Zhang, B., Huang, Y., & Huang, Y. (2024) · Nanomaterials · doi:10.3390/nano14070648 · Cited by 26 · see citing works

Broadening horizons: the multifaceted role of ferroptosis in breast cancer

Ge, A., Wang, X., Li, Y., Da, Z., Chen, J., Daga, P., Dai, C. C., Yang, K., Yan, Y., Hao, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1455741 · Cited by 25 · see citing works

A Lysosome-Targeted Iridium(III) Complex Inducing Pyroptosis for Enhanced Sonodynamic Therapy of Colorectal Cancer

Guan, L., Tao, S., Lu, X., Jiang, Y. Y., Xu, K., Peng, J., Shen, W., Guo, G.-H., Shen, Z., & Ru, J. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01106 · Cited by 25 · see citing works

Immunometabolism of ferroptosis in the tumor microenvironment

Lupica-Tondo, G. L., Arner, E. N., Mogilenko, D. A., & Voss, K. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1441338 · Cited by 26 · see citing works

Progress of Piezoelectric Semiconductor Nanomaterials in Sonodynamic Cancer Therapy

He, F., Li, W., Liu, B., Zhong, Y., Jin, Q., & Qin, X. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01232 · Cited by 24 · see citing works

Facile synthesis of a hydrazone-based zinc( ii ) complex for ferroptosis-augmented sonodynamic therapy

Li, D., Fan, M., Wang, H., Zhu, Y., Yu, B., Zhang, P., & Huang, H. (2024) · Chemical Science · doi:10.1039/d4sc02102a · Cited by 23 · see citing works

IR-820@NBs Combined with MG-132 Enhances the Anti-Hepatocellular Carcinoma Effect of Sonodynamic Therapy

Wang, X., Wang, C., Tian, H., Chen, Y., Wu, B., & Cheng, W. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s431910 · Cited by 22 · see citing works

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H2S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Zhao, J., Bian, E., Zhang, R., Xu, T., Nie, Y., Wang, L., Jin, G., Xie, H., Xiang, H., Chen, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202309542 · Cited by 22 · see citing works

Tumor microenvironment triggered iron-based metal organic frameworks for magnetic resonance imaging and photodynamic-enhanced ferroptosis therapy

Xie, M., Jiang, C., Zhang, C., Wu, Y., Zhang, X., Yao, R., Han, C., Dai, Y., Xu, K., & Zheng, S. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.01.119 · Cited by 21 · see citing works

Activatable Plasmonic Versatile Nanoplatform for Glutathione-Depletion Augmented Ferroptosis and NIR-II Photothermal Synergistic Therapy

Sun, T., Zhang, L., Xiao, S., Xie, Q., Wang, M., Zhao, Y., Zhou, C., Gong, M., & Zhang, D. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c01533 · Cited by 20 · see citing works

Synergistic antibacterial effects of ultrasound combined nanoparticles encapsulated with cellulase and levofloxacin on Bacillus Calmette-Guérin biofilms

Zhang, Z., Zhang, Y., Yang, M., Hu, C., Liao, H., Li, D., & Du, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1108064 · Cited by 19 · see citing works

Synthesis and anticancer mechanisms of four novel platinum( ii ) 4′-substituted-2,2′:6′,2′′-terpyridine complexes

Liang, C.-J., Wu, R.-C., Huang, X., Qin, Q., Liang, H., & Tan, M. (2023) · Dalton Transactions · doi:10.1039/d3dt03197g · Cited by 19 · see citing works

Iridium(III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy

Zeng, Y., Liu, L., Ma, T., Liu, Y., Liu, B., Liu, W., Shen, Q., Wu, C., & Mao, Z. (2024) · Angewandte Chemie · doi:10.1002/ange.202410803 · Cited by 18 · see citing works

Ultrasound-activatable transition metal complexes to potentiate sonodynamic therapy

Lee, L. C., & Lo, K. K. (2025) · Chemical Science · doi:10.1039/d5sc06387f · Cited by 16 · see citing works

Metal complexes in medicine: structural scaffolds vs. functional centres

Montesdeoca, N., & Karges, J. (2026) · Chemical Science · doi:10.1039/d6sc01182a · Cited by 15 · see citing works

Organic Semiconducting Polymers for Cancer Sonodynamic Immunotherapy

Hu, P., He, S., & Tian, H. (2025) · Polymer science & technology. · doi:10.1021/polymscitech.5c00112 · Cited by 12 · see citing works

Recent advances and pathological mechanisms in photodynamic and sonodynamic therapy in the treatment of bone tumors (Review)

Hou, Y., Zhao, D., Yang, X., Guo, C., Wen, M., Bao, J., Qu, G., & Meng, H. (2023) · Oncology Reports · doi:10.3892/or.2023.8635 · Cited by 11 · see citing works

Beyond chemotherapy: Spatiotemporal activation of metal complexes for deep-tissues precision medicine

Pang, Y., Zhao, F., Wang, Y., Song, Q., Wang, Q., Li, J., Zhang, R., & Sun, Y. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216664 · Cited by 10 · see citing works

Multifunctional Oxygen-Generating Nanoflowers for Enhanced Tumor Therapy

Sun, W., Xiao, H., Zhu, J., Hao, Z., Sun, J., Wang, D., Wang, X., Ramalingam, M., Xie, S., & Wang, R. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00678 · Cited by 10 · see citing works

Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti‐tumor Metallic complexes

Zhou, Y., Zhao, T., Tao, S., Wang, P., Guan, Y., Yang, K., Chen, S., & Pu, X. (2023) · Chemistry - An Asian Journal · doi:10.1002/asia.202301020 · Cited by 10 · see citing works

Unlocking the potential of iridium-osmium carbolong conjugates: a high-performance photocatalyst for melanoma therapy

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Magnetic Microbubbles Combined with ICG-Loaded Liposomes for Synergistic Mild-Photothermal and Ferroptosis-Enhanced Photodynamic Therapy of Melanoma

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Advances in Sonodynamic Therapy: Focus on Ferroptosis

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Tumor Microenvironment‐Related Sonodynamic Therapy Mediates Tumor Therapy

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Dual‐Functional Iridium Complex for Tumor Treatment via Ultrasound Driven Water‐Splitting Oxygen Evolution Cascade Sonodynamic Therapy

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Rational molecular design and emerging applications of small-molecule sonosensitizers for sonodynamic therapy

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A curcumin-based HDACs inhibitor for targeted sonodynamic therapy of breast cancer

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Evoking Ferroptosis by Synergistic Enhancement of a Cyclopentadienyl Iridium‐Betulin Immune Agonist

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Dimerized sesquiterpenoid [4 + 2] adducts with ferroptosis-promoting activity from Inula britannica Linn

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Laser–Ultrasound Responsive Nanoreactor to Remodel the Microenvironment of Antibiotic-Resistant Bacterial Infection for Diabetic Wound Healing

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Platinum nanoparticle-anchored metal–organic complex nanospheres by a coordination–crystallization approach for enhanced sonodynamic therapy of tumors

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Pt( iv ) prodrug as a potent nanosonosensitizer self-cyclically amplifies sonodynamic-chemotherapy with dually reversing cisplatin resistance

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An endoplasmic reticulum and lipid droplets dual-localized strategy to develop small molecular photosensitizers that induce ferroptosis during photodynamic therapy

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Nanocatalytic medicine: An advanced catalysis-based imaging and therapy methodology

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Bioinspired Construction of Cu–Fe Bimetallic Multienzyme Mimetics as Co-Inducers of Cuproptosis and Ferroptosis

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Enhanced sonodynamic therapy and theranostic integration for breast cancer treatment: nanomaterial-driven multifunctional platforms

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Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies

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Inherently anti-metastatic peptide hydrogels for sonodynamic-amplified ferroptosis in cancer therapy

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Three novel dinuclear calcium( ii ) complexes with 5,7-dihalo-8-quinolinolato showing potent anticancer activity

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From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation

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TiO 2 -Nanoparticle–Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism

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Ultrasound-activated rhenium(I)-cyanine nanoagent for simultaneous hydroxyl radical/CO generation: Synergistic eradication of drug-resistant bacterial infections and enhanced wound healing

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Recent advances in stimuli-responsive microrobots for biomedical applications

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The role of ferroptosis in the pathogenesis and treatment of breast cancer

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Harnessing External Irradiation for Precise Activation of Metal‐Based Agents in Cancer Therapy

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FeMoO y @MoS x heterostructure coated by cell membrane to promote sono/chemodynamic tumor treatment

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Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects

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Recent advances of metal-based sonosensitizers in cancer therapy

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Progress in metal complex-based nanoplatform for cancer sonodynamic immunotherapy: mechanistic insights, structural designs, challenges and perspectives

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Stimuli-responsive nanoplatforms for sonodynamic immunotherapy: opportunities and challenges in cancer treatment

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Tumor-associated stimuli-responsive sonosensitizers for precise sonodynamic therapy

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Ultrasound‐Activated Theranostic Materials and Their Bioapplications

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Ultrasound-activated nanomedicines for hepatocellular carcinoma: A new frontier in cancer theranostics

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Near-Infrared Phosphorescence Micelles with λ em > 800 nm Constructed by Block Copolymers and Platinum(II) Complexes: Integrating Bioimaging and Tumor Chemotherapy

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Multidimensional Exploration of Platinum Complexes for Cancer Therapy

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Multidimensional Exploration of Platinum Complexes for Cancer Therapy

Jin, S., & Wang, X. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.6256371

Theranostic Platinum(II) Supramolecular Assembly: Differential Excited‐State Dynamics Enabling Synergistic Chemo‐Photodynamic Therapy With Real‐Time Tracking

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Advances in sonodynamic therapy for metal complexes in biomedical research: challenges and future perspectives

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Organic sonosensitizers for cancer therapy: molecular engineering from band-gap control to clinical application

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Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

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Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

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Development of a visible light-responsive cyanine functionalized Ru( ii )-polypyridyl photosensitizer: synthesis, characterization, photophysical properties, and theoretical investigation

Mandal, A. A., & Banerjee, S. (2026) · New Journal of Chemistry · doi:10.1039/d6nj03173k

Cisplatin Conjugated with Vinylsulfonamide Cross-Links Pyruvate Kinase M2 to Trigger Ferroptosis

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Novel metallophthalocyanines bearing 2-(2-bromophenyl)ethoxy groups: Elucidating the effect of the central atom on singlet oxygen production via photochemical and sono-photochemical processes

Bal, B., Kutlu, Ö. D., Değirmencioğlu, İ., & Erdoğmuş, A. (2025) · Polyhedron · doi:10.1016/j.poly.2025.117700 · Cited by 3 · see citing works

An ultrasound activated cyanine-rhenium( i ) complex for sonodynamic and gas synergistic therapy

Zhu, J., Ouyang, A., He, J., Xie, J., Banerjee, S., Zhang, Q., & Zhang, P. (2022) · Chemical Communications · doi:10.1039/d1cc06769a · Cited by 60 · see citing works

Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy

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Induction of Ferroptosis of Iridium(Iii) Complexes Localizing at the Mitochondria and Lysosome by Photodynamic TherapyPreprint

Liu, Y., Niu, Y., Tang, S., Li, J., Huang, C., Yang, Y., Zhou, L., & Zeng, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4989889

Sonoinduced Tumor Therapy and Metastasis Inhibition by a Ruthenium Complex with Dual Action: Superoxide Anion Sensitization and Ligand Fracture

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