The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation
Abstract
Pyroptosis as a lytic and inflammatory form of cell death is a powerful tool to fight against cancer. However, pyroptosis is usually activated by chemotherapeutic drugs, which limits its anti‐tumor applications due to drug resistance and severe side effects. Herein, we demonstrate that membrane targeting photosensitizers can induce pyroptosis for cancer cell ablation with noninvasiveness and low side effects. A series of membrane anchoring photosensitizers (TBD‐R PSs) with aggregation‐induced emission (AIE) characteristics were prepared through conjugation of TBD and phenyl ring with cationic chains. Upon light irradiation, cytotoxic ROS were produced in situ, resulting in direct membrane damage and superior cancer cell ablation. Detailed study revealed that pyroptosis gradually became the dominant cell death pathway along with the increase of TBD‐R PSs membrane anchoring capability. This study offers a photo‐activated pyroptosis‐based intervention strategy for cancer cell ablation.
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Cites
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
Shi, J., Gao, W., & Shao, F. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.004 · Cited by 3,088
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Self-citation
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Pyroptosis in inflammatory diseases and cancer
Rao, Z., Zhu, Y., Yang, P., Chen, Z., Xia, Y., Qiao, C., Liu, W., Deng, H., Li, J., Ning, P., et al. (2022) · Theranostics · doi:10.7150/thno.71086 · Cited by 800
The fast-growing field of photo-driven theranostics based on aggregation-induced emission
Zhang, Z., Kang, M., Tan, H., Song, N., Li, M., Xiao, P., Yan, D., Zhang, L., Wang, D., & Tang, B. Z. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01138c · Cited by 374
ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy
Ding, B., Chen, H., Tan, J., Meng, Q., Zheng, P., Ma, P., & Lin, J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202215307 · Cited by 348
Self-citationMicroenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy
Xiao, Y., Zhang, T., Ma, X., Yang, Q., Yang, L., Yang, S., Liang, M., Xu, Z., & Sun, Z. (2021) · Advanced Science · doi:10.1002/advs.202101840 · Cited by 325
Metadata
- Authors
- Wu, M., Liu, X., Chen, H., Duan, Y., Liu, J., Pan, Y., & Liu, B.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-03-08
- Volume
- 60
- Issue
- 16
- Pages
- 9093-9098
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3128195390
- Cited by
- 315
- References
- 5
- FWCI
- 30.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, M., Liu, X., Chen, H., Duan, Y., Liu, J., Pan, Y., & Liu, B. (2021). Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202016399
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