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Cited by 1,102

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Stem cell therapy in a caprine model of osteoarthritis

Murphy, J. Mary, Fink, David J., Hunziker, Ernst B., Barry, Frank P.·2003·Arthritis & Rheumatism
DOI 10.1002/art.11365
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Abstract

Objective: To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods: Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results: In cell‐treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell‐treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion: Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA.

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Metadata

Authors
Murphy, J. M., Fink, D. J., Hunziker, E. B., & Barry, F. P.
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
2003-12
Volume
48
Issue
12
Pages
3464-3474
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.11365
OpenAlex
W2070435400
Cited by
1,102
References
2
FWCI
10.54
Type
journal article
Language
en
Open access
closed

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