Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation
Abstract
Serum concentrations of luteinizing hormone, follicle‐stimulating hormone, prolactin, 17 beta‐estradiol, testosterone, androstenedione, dehydrotestosterone, dehydroepiandrosterone sulfate, and cortisol were examined in 14 men with rheumatoid arthritis (RA) and in age‐matched osteoarthritis controls. Hypophyseal, adrenal, and testicular responses to stimulation with luteinizing hormone‐‐releasing hormone, adrenocorticotropin, and human chorionic gonadotropin, respectively, were evaluated in 8 RA patients and in 8 age‐matched healthy volunteers. Basal serum testosterone concentrations were significantly lower in male RA patients than in the osteoarthritis control subjects (P < 0.01). After human chorionic gonadotropin stimulation, serum concentrations of testosterone were also lower in the RA patients than in normal healthy controls (P < 0.05). These findings suggest that diminished testicular steroid biosynthesis might contribute to the serum testosterone deficiency observed in male RA patients.
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In chronic inflammatory diseases of different etiology, serum androgens are very low.
“In CIDs of different etiology, serum androgens are very low [94-96], but estrogen levels remain relatively normal as a consequence of increased conversion of androgens into estrogens in inflamed tissue [97].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [95]
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- Authors
- Cutolo, M., Balleari, E., Giusti, M., Monachesi, M., & Accardo, S.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Cutolo, Maurizio
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1988-10
- Volume
- 31
- Issue
- 10
- Pages
- 1314-1317
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2009725993
- Cited by
- 144
- References
- 17
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- rheumatoid arthritis, male patients, androgen deficiency, sex hormones, human chorionic gonadotropin stimulation, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, androstenedione, dehydroepiandrosterone sulfate, cortisol, hypogonadism
- MeSH terms
- Adult, Aged, Arthritis, Rheumatoid, Follicle Stimulating Hormone, Chorionic Gonadotropin, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Middle Aged, Osmolar Concentration, Gonadal Steroid Hormones, Stimulation, Chemical, Testosterone
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