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Dehydroepiandrosterone in systemic lupus erythematosus
Abstract
OBJECTIVE: To determine if dehydroepiandrosterone (DHEA) is beneficial in the treatment of systemic lupus erythematosus (SLE). METHODS: In a double-blind, placebo-controlled, randomized trial, 28 female patients with mild to moderate SLE were given DHEA 200 mg/day or placebo for 3 months. Outcomes included the SLE Disease Activity Index (SLEDAI) score, patient's and physician's overall assessments of disease activity, and concurrent corticosteroid dosages (which were adjusted as clinically indicated). RESULTS: In the patients who were receiving DHEA, the SLEDAI score, patient's and physician's overall assessment of disease activity, and concurrent prednisone dosage decreased, while in the patients taking placebo, small increases were seen. The difference in patient's assessment between the groups was statistically significant (P = 0.022, adjusted). Lupus flares occurred more frequently in the placebo group (P = 0.053). Mild acne was a frequent side effect of DHEA. CONCLUSION: DHEA may be useful as a therapeutic agent for the treatment of mild to moderate SLE. Further studies of DHEA in the treatment of SLE are warranted.
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“DHEA treatment in glucocorticoid-treated patients with systemic lupus erythematosus (327, 328) led to significant improvement in overall performance and activity.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [327]
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Metadata
- Authors
- Van Vollenhoven, R. F., Engleman, E. G., & Mcguire, J. L.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Engleman, Edgar G.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 38
- Issue
- 12
- Pages
- 1826-1831
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2070207717
- Cited by
- 192
- References
- 36
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- dehydroepiandrosterone, systemic lupus erythematosus, lupus flares, corticosteroid tapering, prednisone, SLEDAI, disease activity, acne, steroid-sparing therapy
- MeSH terms
- Adult, Dehydroepiandrosterone, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Lupus Erythematosus, Systemic, Prednisone, Severity of Illness Index, Chi-Square Distribution
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