The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Treatment of giant cell arteritis using induction therapy with high‐dose glucocorticoids: A double‐blind, placebo‐controlled, randomized prospective clinical trial
Abstract
Objective: Glucocorticoid (GC) therapy for giant cell arteritis (GCA) is effective but requires prolonged administration, resulting in adverse side effects. The goal of the current study was to test the hypothesis that induction treatment with high‐dose pulse intravenous (IV) methylprednisolone permits a shorter course of therapy. Methods: Twenty‐seven patients with biopsy‐proven GCA were enrolled in a randomized, double‐blind, placebo‐controlled study to receive IV methylprednisolone (15 mg/kg of ideal body weight/day) or IV saline for 3 consecutive days. All patients were started on 40 mg/day prednisone and followed the same tapering schedule as long as disease activity was controlled. The numbers of patients with disease in remission after 36, 52, and 78 weeks of treatment and taking ≤5 mg/day prednisone were compared. Cumulative prednisone dose, number of relapses, and development of adverse GC effects were assessed. Results: Ten of the 14 IV GC–treated patients, but only 2 of 13 control patients, were taking ≤5 mg/day prednisone at 36 weeks (P = 0.003). This difference was maintained; there was a higher number of sustained remissions after discontinuation of treatment in the IV GC–treated group and a lower median daily dose of prednisone at 78 weeks (P = 0.0004). The median cumulative dose of oral prednisone, excluding the IV GC dose, was 5,636 mg in the IV GC–treated group compared with 7,860 mg in the IV saline–treated group (P = 0.001). Conclusion: Initial treatment of GCA with IV GC pulses allowed for more rapid tapering of oral GCs and had long‐term benefits, with a higher frequency of patients experiencing sustained remission of their disease after discontinuation of treatment.
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Cites
The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis
Hunder, G. G., Bloch, D. A., Michel, B. A., Stevens, M. B., Arend, W. P., Calabrese, L. H., Edworthy, S. M., Fauci, A. S., Leavitt, R. Y., Lie, J. T., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330810 · Cited by 2,539
Self-citationPolymyalgia Rheumatica and Giant-Cell Arteritis
Salvarani, C., Cantini, F., Boiardi, L., & Hunder, G. G. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011913 · Cited by 1,352
Self-citationMedium- and Large-Vessel Vasculitis
Weyand, C. M., & Goronzy, J. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022694 · Cited by 788
Self-citationGlucocorticoid therapy in giant cell arteritis: Duration and adverse outcomes
Proven, A., Gabriel, S. E., Orces, C., O'Fallon, W. M., & Hunder, G. G. (2003) · Arthritis Care & Research · doi:10.1002/art.11388 · Cited by 612
Self-citationEvans, J. M., O'Fallon, W. M., & Hunder, G. G. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-7-199504010-00004 · Cited by 597
Self-citationHoffman, G. S., Cid, M. C., Hellmann, D. B., Guillevin, L., Stone, J. H., Schousboe, J., Cohen, P., Calabrese, L. H., Dickler, H., Merkel, P. A., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10262 · Cited by 579
Self-citationNuenninghoff, D. M., Hunder, G. G., Christianson, T. J. H., McClelland, R. L., & Matteson, E. L. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11353 · Cited by 568
Self-citationVisual Prognosis in Giant Cell Arteritis
Aiello, P. D., Trautmann, J. C., McPhee, T. J., Kunselman, A. R., & Hunder, G. G. (1993) · Ophthalmology · doi:10.1016/s0161-6420(93)31608-8 · Cited by 388
Self-citationGiant-Cell Arteritis and Polymyalgia Rheumatica
Weyand, C. M., & Goronzy, J. J. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-6-200309160-00015 · Cited by 379
Self-citationAchkar, A. A., Lie, J. T., Hunder, G. G., O'Fallon, W. M., & Gabriel, S. E. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-12-199406150-00003 · Cited by 366
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Cited by
Kleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K. M., Gutierrez, J., Lombardi-Hill, D., Kamel, H., Kernan, W. N., Kittner, S. J., Leira, E. C., et al. (2021) · Stroke · doi:10.1161/str.0000000000000375 · Cited by 3,237
Isselbacher, E. M., Preventza, O., Hamilton Black, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001106 · Cited by 2,082
Polymyalgia rheumatica and giant-cell arteritis
Salvarani, C., Cantini, F., & Hunder, G. G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61077-6 · Cited by 767
Self-citationPolymyalgia Rheumatica and Giant Cell Arteritis
Ettlinger, R. E., Hunder, G. G., & Ward, L. E. (1978) · Annual Review of Medicine · doi:10.1146/annurev.me.29.020178.000311 · Cited by 687
Self-citationGiant cell arteritis: A review of classification, pathophysiology, geoepidemiology and treatment
Borchers, A. T., & Gershwin, M. E. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.01.003 · Cited by 256
Metadata
- Authors
- Mazlumzadeh, M., Hunder, G. G., Easley, K. A., Calamia, K. T., Matteson, E. L., Griffing, W. L., Younge, B. R., Weyand, C. M., & Goronzy, J. J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2006-09-28
- Volume
- 54
- Issue
- 10
- Pages
- 3310-3318
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1992168643
- Cited by
- 347
- References
- 25
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mazlumzadeh, M., Hunder, G. G., Easley, K. A., Calamia, K. T., Matteson, E. L., Griffing, W. L., Younge, B. R., Weyand, C. M., & Goronzy, J. J. (2006). Treatment of giant cell arteritis using induction therapy with high‐dose glucocorticoids: A double‐blind, placebo‐controlled, randomized prospective clinical trial. Arthritis & Rheumatism. https://doi.org/10.1002/art.22163
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