Cited by 648Osteoarthritis Treatment and MechanismsProtease and Inhibitor MechanismsProteoglycans and glycosaminoglycans research

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

Open access

Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., Thompson, E. W.·2009·Arthritis & Rheumatism

DOI 10.1002/art.25002PMC PMC2832925

Open this paper in CoChat — free account

Abstract

Objective: To investigate the role of matrix metalloproteinase 13 (MMP‐13; collagenase 3) in osteoarthritis (OA). Methods: OA was surgically induced in the knees of MMP‐13–knockout mice and wild‐type mice, and mice were compared. Histologic scoring of femoral and tibial cartilage aggrecan loss (0–3 scale), erosion (0–7 scale), and chondrocyte hypertrophy (0–1 scale), as well as osteophyte size (0–3 scale) and maturity (0–3 scale) was performed. Serial sections were stained for type X collagen and the MMP‐generated aggrecan neoepitope DIPEN. Results: Following surgery, aggrecan loss and cartilage erosion were more severe in the tibia than femur ( P < 0.01) and tibial cartilage erosion increased with time ( P < 0.05) in wild‐type mice. Cartilaginous osteophytes were present at 4 weeks and underwent ossification, with size and maturity increasing by 8 weeks ( P < 0.01). There was no difference between genotypes in aggrecan loss or cartilage erosion at 4 weeks. There was less tibial cartilage erosion in knockout mice than in wild‐type mice at 8 weeks ( P < 0.02). Cartilaginous osteophytes were larger in knockout mice at 4 weeks ( P < 0.01), but by 8 weeks osteophyte maturity and size were no different from those in wild‐type mice. Articular chondrocyte hypertrophy with positive type X collagen and DIPEN staining occurred in both wild‐type and knockout mouse joints. Conclusion: Our findings indicate that structural cartilage damage in a mouse model of OA is dependent on MMP‐13 activity. Chondrocyte hypertrophy is not regulated by MMP‐13 activity in this model and does not in itself lead to cartilage erosion. MMP‐13 deficiency can inhibit cartilage erosion in the presence of aggrecan depletion, supporting the potential for therapeutic intervention in established OA with MMP‐13 inhibitors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/art.25002

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
Glasson, S. S., Blanchet, T., & Morris, E. A. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.03.006 · Cited by 1,524
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Glasson, S. S., Askew, R., Sheppard, B. J., Carito, B. A., Blanchet, T., Ma, H., Flannery, C. R., Peluso, D., Kanki, K., Yang, Z., et al. (2005) · Nature · doi:10.1038/nature03369 · Cited by 1,258
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.
Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C. H., Mitchell, P. G., Hambor, J., Diekmann, O., Tschesche, H., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119316 · Cited by 970
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Stanton, H., Rogerson, F. M., East, C. J., Golub, S. B., Lawlor, K. E., Meeker, C. T., Little, C. B., Last, K., Farmer, P. J., Campbell, I. K., et al. (2005) · Nature · doi:10.1038/nature03417 · Cited by 920
Self-citation
Matrix Metalloproteinases as Modulators of Inflammation
MANICONE, A., & MCGUIRE, J. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2007.07.003 · Cited by 617
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
Stickens, D., Behonick, D. J., Ortéga, N., Heyer, B. S., Hartenstein, B., Yu, Y., Fosang, A., Schorpp‐Kistner, M., Angel, P. E., & Werb, Z. (2004) · Development · doi:10.1242/dev.01461 · Cited by 608
Self-citation
Osteoarthritis development in novel experimental mouse models induced by knee joint instability
Kamekura, S., Hoshi, K., Shimoaka, T., Chung, U., Chikuda, H., Yamada, T., Uchida, M., Ogata, N., Seichi, A., Nakamura, K., et al. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.03.004 · Cited by 583
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
Inada, M., Wang, Y., Byrne, M. H., Rahman, M. U., Miyaura, C., López-Otı́n, C., & Krane, S. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407788101 · Cited by 576
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
Neuhold, L. A., Killar, L. M., Zhao, W., Sung, M.-L. A., Warner, L. F., Kulik, J., Turner, J. R., Wu, W. K. K., Billinghurst, C., Meijers, T. H. M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10564 · Cited by 541
Aggrecanases and cartilage matrix degradation.
Nagase, H., & Kashiwagi, M. (2003) · Arthritis Research · doi:10.1186/ar630 · Cited by 420

Flagged first, then by citations

Show all 54 references

Research works printed but not linked: 1

Ma HL, 2005, Disease progression in surgically induced murine osteoarthritis is strain and sex dependent, Trans Orth Res Soc, 30, 1422

Sorted by citations

Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,234
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Chen, D., Shen, J., Zhao, W., Wang, T., Han, L., Hamilton, J. L., & Im, H. (2017) · Bone Research · doi:10.1038/boneres.2016.44 · Cited by 1,221
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee
Jang, S., Lee, K.-J., & Ju, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052619 · Cited by 879
Proteases involved in cartilage matrix degradation in osteoarthritis
Troeberg, L., & Nagase, H. (2011) · Biochimica et Biophysica Acta · doi:10.1016/j.bbapap.2011.06.020 · Cited by 599
The role of the cartilage matrix in osteoarthritis
Heinegård, D. K., & Saxne, T. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.198 · Cited by 554
The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review
Mehana, E.-S. E., Khafaga, A. F., & Elblehi, S. S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116786 · Cited by 544
Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms
Xia, B., Chen, D., Zhang, J., Hu, S., Jin, H., & Tong, P. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9917-9 · Cited by 543
NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction
Choi, M., Jo, J., Park, J., Kang, H. K., & Park, Y. (2019) · Cells · doi:10.3390/cells8070734 · Cited by 563
Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
Saito, T., Fukai, A., Mabuchi, A., Ikeda, T., Yano, F., Ohba, S., Nishida, N., Akune, T., Yoshimura, N., Nakagawa, T., et al. (2010) · Nature Medicine · doi:10.1038/nm.2146 · Cited by 532
MMP13 is a critical target gene during the progression of osteoarthritis
Wang, M., Sampson, E. R., Jin, H., Li, J., Ke, Q. H., Im, H., & Chen, D. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4133 · Cited by 513
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
Goldring, M., Otero, M., Plumb, D. A., Dragomir, C. L., Favero, M., El-Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., Borzı̀, R. M., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 499
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
Hu, Q., & Ecker, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041742 · Cited by 504
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis
Goldring, M. B. (2012) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12448454 · Cited by 470
Emerging pharmaceutical therapies for osteoarthritis
Latourte, A., Kloppenburg, M., & Richette, P. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00518-6 · Cited by 434
Basic Science of Articular Cartilage
Carballo, C. B., Nakagawa, Y., Sekiya, I., & Rodeo, S. A. (2017) · Clinics in Sports Medicine · doi:10.1016/j.csm.2017.02.001 · Cited by 413
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
Rim, Y. A., Nam, Y., & Ju, J. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072358 · Cited by 386
Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models
He, Y., Li, Z. A., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 420
Cellular senescence in osteoarthritis pathology
McCulloch, K., Litherland, G. J., & Rai, T. S. (2017) · Aging Cell · doi:10.1111/acel.12562 · Cited by 367
Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis
Kim, J., Jeon, J., Shin, M., Won, Y., Lee, M., Kwak, J.-S., Lee, G., Rhee, J., Ryu, J., Chun, C. H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.007 · Cited by 369
Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders
Dreier, R. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3117 · Cited by 357
Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis
Huang, J., Fu, X., Chen, X., Li, Z., Huang, Y., & Liang, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686155 · Cited by 367
Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis
Houard, X., Goldring, M. B., & Berenbaum, F. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0375-6 · Cited by 355
The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis
Choi, W.-S., Lee, G., Song, W., Koh, J., Yang, J., Kwak, J.-S., Kim, H., Kim, S. K., Son, Y., Nam, H., et al. (2019) · Nature · doi:10.1038/s41586-019-0920-1 · Cited by 341
Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
Charlier, E., Relić, B., Deroyer, C., Malaise, O., Neuville, S., Collée, J., Malaise, M., & de Seny, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122146 · Cited by 341
Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
Pap, T., & Korb‐Pap, A. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.95 · Cited by 319
The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis
Sanchez‐Adams, J., Leddy, H. A., McNulty, A. L., O’Conor, C. J., & Guilak, F. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0451-6 · Cited by 313
Ageing and Osteoarthritis
Sacitharan, P. K. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_6 · Cited by 316
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
Cho, Y., Jeong, S., Kim, H., Kang, D., Lee, J., Kang, S., & Kim, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00710-y · Cited by 320
Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
Chang, S. H., Mori, D., Kobayashi, H., Mori, Y., Nakamoto, H., Okada, K., Taniguchi, Y., Sugita, S., Yano, F., Chung, U., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09491-5 · Cited by 304
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
Li, H., Wang, D., Yuan, Y., & Min, J. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1454-2 · Cited by 293
Post-traumatic osteoarthritis: from mouse models to clinical trials
Little, C., & Hunter, D. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.72 · Cited by 291
Self-citation
Etiology of osteoarthritis: genetics and synovial joint development
Sandell, L. J. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.199 · Cited by 286
TGF-β Family Signaling in Mesenchymal DifferentiationPreprint
Grafe, I., Alexander, S., Peterson, J. R., Snider, T. N., Lévi, B., Lee, B., & Mishina, Y. M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022202 · Cited by 278
Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis
Withrow, J. S., Murphy, C., Liu, Y., Hunter, M., Fulzele, S., & Hamrick, M. W. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1178-8 · Cited by 277
Cartilage biology in osteoarthritis—lessons from developmental biology
Pitsillides, A. A., & Beier, F. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.129 · Cited by 254
TGF-β signaling and the development of osteoarthritis
Shen, J., Li, S., & Chen, D. (2014) · Bone Research · doi:10.1038/boneres.2014.2 · Cited by 243
Inflammation and epigenetic regulation in osteoarthritis
Shen, J., Abu‐Amer, Y., O’Keefe, R. J., & McAlinden, A. (2016) · Connective Tissue Research · doi:10.1080/03008207.2016.1208655 · Cited by 232
Matrix metalloproteinases in arthritis: towards precision medicine
Grillet, B. A. M., Pereira, R. V. S., Damme, J. V., El‐Asrar, A. M. A., Proost, P., & Opdenakker, G. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00966-w · Cited by 217
Anabolic/Catabolic Balance in Pathogenesis of Osteoarthritis: Identifying Molecular Targets
Mueller, M. B., & Tuan, R. S. (2011) · PM&R · doi:10.1016/j.pmrj.2011.05.009 · Cited by 208
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis
Wang, M., Shen, J., Jin, H., Im, H., Sandy, J. D., & Chen, D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06258.x · Cited by 201
Osteoarthritis year 2010 in review: pathomechanisms
van den Berg, W. B. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.01.022 · Cited by 200
Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
Chan, B. Y., Fuller, E. S., Russell, A. K., Smith, S. M., Smith, M. M., Jackson, M. T., Cake, M. A., Read, R. A., Bateman, J. F., Sambrook, P. N., et al. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.04.014 · Cited by 200
Self-citation
Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis
Ruan, M. Z. C., Erez, A., Guse, K., Dawson, B., Bertin, T., Chen, Y., Jiang, M.-M., Yustein, J., Gannon, F., & Lee, B. H. L. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005409 · Cited by 196
The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies
Kang, D., Lee, J., Wu, C., Guo, X., Lee, B. J., Chun, J., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0408-y · Cited by 192
Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis‐like Phenotype in Mice
Shen, J., Li, J., Wang, B., Jin, H., Wang, M., Zhang, Y., Yang, Y., Im, H., O’Keefe, R. J., & Chen, D. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38122 · Cited by 189
A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology
Rose, B. J., & Kooyman, D. L. (2016) · Disease Markers · doi:10.1155/2016/4895050 · Cited by 184
Interleukin‐6 plays an essential role in hypoxia‐inducible factor 2α–induced experimental osteoarthritic cartilage destruction in mice
Ryu, J., Yang, S., Shin, Y., Rhee, J., Chun, C. H., & Chun, J. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30451 · Cited by 182
Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage
Sheu, S.-Y., Ho, S.-R., Sun, J.-S., Chen, C.-Y., & Ke, C.-J. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0520-z · Cited by 181
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
Yamamoto, K., Okano, H., Miyagawa, W., Visse, R., Shitomi, Y., Santamaria, S., Dudhia, J., Troeberg, L., Strickland, D. K., Hirohata, S., et al. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.03.007 · Cited by 181
Signaling Pathways in Cartilage Repair
Mariani, E., Pulsatelli, L., & Facchini, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058667 · Cited by 185
Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB
Saito, T., & Tanaka, S. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1296-y · Cited by 179
Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis
Sampson, E. R., Hilton, M. J., Tian, Y., Chen, D., Schwarz, E. M., Mooney, R. A., Bukata, S. V., O’Keefe, R. J., Awad, H. A., Puzas, J. E., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002214 · Cited by 173
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
Singh, P., Marcu, K. B., Goldring, M. B., & Otero, M. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13930 · Cited by 179
Characterizing a novel and adjustable noninvasive murine joint loading model
Poulet, B., Hamilton, R. W., Shefelbine, S. J., & Pitsillides, A. A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27765 · Cited by 173
Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review
Tateiwa, D., Yoshikawa, H., & Kaito, T. (2019) · Cells · doi:10.3390/cells8080818 · Cited by 175
Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration
Koike, M., Nojiri, H., Ozawa, Y., Watanabe, K., Muramatsu, Y., Kaneko, H., Morikawa, D., Kobayashi, K., Saita, Y., Sasho, T., et al. (2015) · Scientific Reports · doi:10.1038/srep11722 · Cited by 169
On the predictive utility of animal models of osteoarthritis
Malfait, A., & Little, C. B. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0747-6 · Cited by 168
Self-citation
Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis
Goldring, M. B., & Marcu, K. B. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.11.005 · Cited by 171
Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo
Burleigh, A., Chanalaris, A., Gardiner, M. D., Driscoll, C., Boruc, O., Saklatvala, J., & Vincent, T. L. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34420 · Cited by 161
C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
Hirata, M., Kugimiya, F., Fukai, A., Saito, T., Yano, F., Ikeda, T., Mabuchi, A., Sapkota, B. R., Akune, T., Nishida, N., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr540 · Cited by 159
Articular Cartilage Degradation in Osteoarthritis
Goldring, M. B. (2012) · HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery · doi:10.1007/s11420-011-9250-z · Cited by 155
Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage
Wei, F., Zhou, J., Wei, X., Zhang, J., Fleming, B. C., Terek, R. M., Pei, M., Chen, Q., Liu, T., & Wei, L. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.03.010 · Cited by 151
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis
Knights, A. J., Farrell, E. C., Ellis, O. M., Lammlin, L., Junginger, L. M., Rzeczycki, P., Bergman, R. F., Pervez, R., Cruz, M., Knight, E., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-222773 · Cited by 155
New molecular targets for the treatment of osteoarthritis
Alcaraz, M. J., Megías, J., García-Arnandis, I., Clérigues, V., & Guillén, M. I. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.02.017 · Cited by 150
Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites
Hashimoto, K., Otero, M., Imagawa, K., de Andrés, M. C., Coico, J. M., Roach, H. I., Oreffo, R. O. C., Marcu, K. B., & Goldring, M. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.421156 · Cited by 152
Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix
Vincent, T. L. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.01.010 · Cited by 136
Chondrocyte hypertrophy in skeletal development, growth, and disease
Sun, M. M., & Beier, F. (2014) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21062 · Cited by 134
Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation
Kuttapitiya, A., Assi, L., Laing, K. G., Hing, C. B., Mitchell, P., Whitley, G. S. J., Harrison, A., Howe, F. A., Ejindu, V., Heron, C. W., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211396 · Cited by 136
Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis
Kang, D., Lee, J., Jung, J., Carlson, B. A., Chang, M. J., Chang, C. B., Kang, S., Lee, B. C., Gladyshev, V. N., Hatfield, D. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28385-7 · Cited by 132
The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
Matsushita, T., Sasaki, H., Takayama, K., Ishida, K., Matsumoto, T., Kubo, S., Matsuzaki, T., Nishida, K., Kurosaka, M., & Kuroda, R. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22268 · Cited by 131
Collagen Type I as a Ligand for Receptor-Mediated Signaling
Boraschi-Diaz, I., Wang, J. P., Mort, J. S., & Komarova, S. V. (2017) · Frontiers in Physics · doi:10.3389/fphy.2017.00012 · Cited by 125
Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis
Kim, J., Yoo, J. J., & Kim, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030674 · Cited by 139
Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction
Ryu, J.-H., Shin, Y., Huh, Y. H., Yang, S., Chun, C.-H., & Chun, J.-S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.111 · Cited by 123
Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies
Wu, Y., Li, J., Zeng, Y., Pu, W., Mu, X., Sun, K., Peng, Y., & Shen, B. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00187-z · Cited by 126
Platelet-Rich Plasma and Cartilage Repair
Kennedy, M. I., Whitney, K. E., Evans, T. A., & LaPrade, R. F. (2018) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-018-9516-x · Cited by 124
Depletion of Protease‐Activated Receptor 2 but Not Protease‐Activated Receptor 1 May Confer Protection Against Osteoarthritis in Mice Through Extracartilaginous Mechanisms
Jackson, M. T., Moradi, B., Zaki, S., Smith, M. M., McCracken, S. A., Smith, S. M., Jackson, C., & Little, C. B. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38876 · Cited by 120
Self-citation
Dkk‐1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice
Oh, H., Chun, C. H., & Chun, J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34481 · Cited by 123
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification
Larkin, J. D., Lohr, T., Elefante, L., Shearin, J., Matico, R., Su, J., Xue, Y., Liu, F., Genell, C. A., Miller, R. E., et al. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.02.778 · Cited by 120
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
Mazur, C. M., Woo, J. J., Yee, C. S., Fields, A. J., Acevedo, C., Bailey, K. N., Kaya, S., Fowler, T. W., Lotz, J. C., Dang, A. C., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0070-y · Cited by 120
Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice
Xu, L., Servais, J. M., Polur, I., Kim, D., Lee, P. L., Chung, K., & Li, Y. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27582 · Cited by 119
Mapping pathogenesis of arthritis through small animal models
Vincent, T. L., Williams, R. O., Maciewicz, R. A., Silman, A. J., & Garside, P. (2012) · Rheumatology · doi:10.1093/rheumatology/kes035 · Cited by 121
MicroRNAs play a role in chondrogenesis and osteoarthritis (Review)
Wu, C., Tian, B., Qu, X., Liu, F., Tang, T., Qin, A., Zhu, Z., & Dai, K. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1743 · Cited by 117
Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu, W., Vasylyev, D. V., Bi, Y., Zhang, M., Sun, G., Khleborodova, A., Huang, G., Zhao, L., Zhou, R., Li, Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06888-7 · Cited by 115
cAMP response element‐binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis
Bui, C., Barter, M. J., Scott, J. L., Xu, Y., Galler, M., Reynard, L. N., Rowan, A. D., & Young, D. A. (2012) · The FASEB Journal · doi:10.1096/fj.12-206367 · Cited by 114
NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis
Yang, S., Ryu, J., Oh, H., Jeon, J., Kwak, J.-S., Kim, J., Kim, H. A., Chun, C. H., & Chun, J. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204355 · Cited by 113
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
Nagai, K., Matsushita, T., Matsuzaki, T., Takayama, K., Matsumoto, T., Kuroda, R., & Kurosaka, M. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.03.024 · Cited by 110
Stimuli-Responsive Nanomedicines for the Treatment of Non-cancer Related Inflammatory Diseases
Yang, J., Rieux, A. D., & Malfanti, A. (2025) · ACS Nano · doi:10.1021/acsnano.5c00700 · Cited by 116
Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice
Ulici, V., Kelley, K. L., Azcárate-Peril, M. A., Cleveland, R. J., Sartor, R. B., Schwartz, T. A., & Loeser, R. F. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.05.016 · Cited by 113
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreER T2 ; Ihhfl/fl mice
Zhou, J., Chen, Q., Lanske, B., Fleming, B. C., Terek, R. M., Wei, X., Zhang, G., Wang, S., Li, K., & Wei, L. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4437 · Cited by 106
MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes
Matsukawa, T., Sakai, T., Yonezawa, T., Hiraiwa, H., Hamada, T., Nakashima, M., Ono, Y., Ishizuka, S., Nakahara, H., Lotz, M., et al. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4164 · Cited by 106
Altered Expression of Circulating MicroRNA in Plasma of Patients with Primary Osteoarthritis and In Silico Analysis of Their Pathways
Borgonio‐Cuadra, V. M., González‐Huerta, N. C., Romero-Cordoba, S. L., Hidalgo‐Miranda, A., & Miranda‐Duarte, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097690 · Cited by 104
MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis
Song, J., Jin, E., Kim, D., Kim, K. Y., Chun, C. H., & Jin, E. (2014) · BBA Clinical · doi:10.1016/j.bbacli.2014.11.009 · Cited by 103
Runx2 plays a central role in Osteoarthritis development
Chen, D., Kim, D. J., Shen, J., Zou, Z., & O’Keefe, R. J. (2019) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2019.11.008 · Cited by 103
Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2
Sugita, S., Hosaka, Y., Okada, K., Mori, D., Yano, F., Kobayashi, H., Taniguchi, Y., Mori, Y., Okuma, T., Chang, S. H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419699112 · Cited by 99
Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice
Hoshi, H., Akagi, R., Yamaguchi, S., Muramatsu, Y., Akatsu, Y., Yamamoto, Y., Sasaki, T., Takahashi, K., & Sasho, T. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2563-y · Cited by 98
Recent Insights into the Contribution of the Changing Hypertrophic Chondrocyte Phenotype in the Development and Progression of Osteoarthritis
Ripmeester, E. G., Timur, U. T., Caron, M. M. J., & Welting, T. J. M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00018 · Cited by 98
Matrix Metalloproteinases in Non-Neoplastic Disorders
Tokito, A., & Jougasaki, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071178 · Cited by 98
The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation
Melrose, J., Shu, C., Whitelock, J. M., & Lord, M. S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.008 · Cited by 96
Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis
Zhang, M., Mani, S. B., He, Y., Hall, A. M., Xu, L., Li, Y., Zurakowski, D., Jay, G. D., & Warman, M. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83676 · Cited by 95

Authors: Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., & Thompson, E. W.
Affiliations: The University of Sydney (AU)
Royal Children's Hospital (AU)
University of California, San Francisco (US)
The University of Melbourne (AU)
ORCID: Little, C. B.
Fosang, A. J.
Werb, Z.
Thompson, E. W.
Venue: Arthritis & Rheumatism
Publisher: Wiley
Published: 2009-11-30
Volume: 60
Issue: 12
Pages: 3723-3733
ISSN: 0004-3591 (ISSN-L)
1529-0131
DOI: 10.1002/art.25002
PMC: PMC2832925
OpenAlex: W2060951121
Cited by: 642
References: 54
Citations by year: 2026: 26 · 2025: 36 · 2024: 39 · 2023: 38 · 2022: 43 · 2021: 42 · 2020: 59 · 2019: 42 · 2018: 35 · 2017: 46 · 2016: 41 · 2015: 42 · 2014: 34 · 2013: 36 · 2012: 29
FWCI: 18.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Arthritis & Rheumatism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Arthritis Australia
National Institutes of Health
Medical Research Council
National Health and Medical Research Council (384414)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR046238, R01AR046238)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: matrix metalloproteinase-13, collagenase-3, osteoarthritis, cartilage erosion, chondrocyte hypertrophy, osteophytes, type X collagen, MMP-13 inhibitors
MeSH terms: Animals, Arthritis, Experimental, Calcinosis, Cartilage, Articular, Femur, Hypertrophy, Joints, Male, Osteoarthritis, Tibia, Mice, Knockout, Chondrocytes, Mice, Matrix Metalloproteinase 13, Aggrecans, Osteophyte

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks