Serotonin neuron abnormalities in the BTBR mouse model of autism

Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

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Autism‐like behavioral phenotypes in BTBR T+tf/J mice

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Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains

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Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence

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The serotonin system in autism spectrum disorder: From biomarker to animal models

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Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors

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Immunohistochemical study of the development of serotonergic neurons in the rat CNS

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BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain

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Corticosteroid–serotonin interactions in the neurobiological mechanisms of stress-related disorders

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Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters

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Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

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Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem

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Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor

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Assessing autism-like behavior in mice: Variations in social interactions among inbred strains

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Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation

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Enhanced Cortisol Response to Stress in Children in Autism

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Multi-Scale molecular deconstruction of the serotonin neuron system

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Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum

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Increased Monoamine Concentration in the Brain and Blood of Fetal Thalidomide- and Valproic Acid-Exposed Rat: Putative Animal Models for Autism

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Platelet serotonin levels in Pervasive Developmental Disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates

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Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors

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Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

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Behavior and serotonergic disorders in rats exposed prenatally to valproate: A model for autism

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The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: a selective overview for the implications of suicide prevention

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A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders

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Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism

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Interaction Between the Forced Swimming Test and Fluoxetine Treatment on Extracellular 5-Hydroxytryptamine and 5-Hydroxyindoleacetic Acid in the Rat

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Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism

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Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior

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Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism

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Social deficits in BTBR <i>T</i> + <i>tf</i>/J mice are unchanged by cross‐fostering with C57BL/6J mothers

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Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system

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Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis

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Challenges in the diagnosis and treatment of depression in autism spectrum disorders across the lifespan

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20 ans après: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition

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Risperidone and the 5‐ HT2A Receptor Antagonist M 100907 Improve Probabilistic Reversal Learning in BTBR T + tf / J Mice

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Postnatal changes in the expressions of serotonin 1A, 1B, and 2A receptors in ten brain stem nuclei of the rat: implication for a sensitive period

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Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin

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Dysfunctional dopaminergic neurotransmission in asocial BTBR mice

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Ascending serotonin neuron diversity under two umbrellas

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Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

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Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder

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Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism

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Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice

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Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice

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Maternal viral infection during pregnancy impairs development of fetal serotonergic neurons

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Engrailed-2(En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior

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Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice

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Neuronal correlates of asocial behavior in a BTBR T+Itpr3tf/J mouse model of autism

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Evidence for topographically organized endogenous 5‐HT‐1A receptor‐dependent feedback inhibition of the ascending serotonin system

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Brain‐derived neurotrophic factor expression is increased in the hippocampus of 5‐HT2C receptor knockout mice

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Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders

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Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice

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Prenatal Expression of MET Receptor Tyrosine Kinase in the Fetal Mouse Dorsal Raphe Nuclei and the Visceral Motor/Sensory Brainstem

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Chronic desipramine treatment rescues depression‐related, social and cognitive deficits in Engrailed‐2 knockout mice

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Time course of expression and function of the serotonin transporter in the neonatal rat's primary somatosensory cortex

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Cued and contextual fear conditioning in BTBR mice is improved with training or atomoxetine

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Autism spectrum disorder: neuropathology and animal models

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The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior

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Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy

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Widespread RNA editing dysregulation in brains from autistic individuals

Tran, S. S., Jun, H.-I., Bahn, J. H., Azghadi, A., Ramaswami, G., Nostrand, E. L. V., Nguyen, T. B., Hsiao, Y.-H. E., Lee, C., Pratt, G. A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0287-x · Cited by 213 · see citing works

The BTBR mouse model of idiopathic autism – Current view on mechanisms

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A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

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Embryonic exposure to valproic acid affects the histaminergic system and the social behaviour of adult zebrafish ( Danio rerio )

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p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

Robson, M. J., Quinlan, M. A., Margolis, K. G., Gajewski-Kurdziel, P. A., Veenstra-VanderWeele, J. M., Gershon, M. D., Watterson, D. M., & Blakely, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809137115 · Cited by 57 · see citing works

Implication of the social function of excessive self-grooming behavior in BTBR T+ltpr3tf/J mice as an idiopathic model of autism

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The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism

Sen, P., Sherwin, E., Sandhu, K., Bastiaanssen, T. F. S., Moloney, G. M., Golubeva, A. V., Fitzgerald, P., Silva, A. P. V., Chruścicka‐Smaga, B., Olavarría‐Ramírez, L., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.08.007 · Cited by 48 · see citing works

Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior

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Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

Long, J., Li, H., Liu, Y., Liao, X., Tang, Z., Han, K., Chen, J., & Zhang, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1364858 · Cited by 43 · see citing works

The brain serotonin system in autism

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Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex

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Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder

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5-HT7 receptor activation rescues impaired synaptic plasticity in an autistic-like rat model induced by prenatal VPA exposure

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Altered medial prefrontal cortex and dorsal raphé activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism‐associated 2p16.3 deletion

Hughes, R. B., Whittingham‐Dowd, J., Clapcote, S. J., Broughton, S. J., & Dawson, N. (2022) · Autism Research · doi:10.1002/aur.2685 · Cited by 24 · see citing works

Review: Dopamine, Serotonin, and the Translational Neuroscience of Aggression in Autism Spectrum Disorder

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Altered nociceptive behavior and emotional contagion of pain in mouse models of autism

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Somatosensorimotor and Odor Modification, Along with Serotonergic Processes Underlying the Social Deficits in BTBR T+ Itpr3tf/J and BALB/cJ Mouse Models of Autism

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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder

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Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism

Bové, M., Palmieri, M. A., Santoro, M., Agosti, L. P., Gaetani, S., Romano, A., Dimonte, S., Costantino, G., Sikora, V., Tucci, P., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02905-z · Cited by 20 · see citing works

16p11.2 deletion syndrome mice perseverate with active coping response to acute stress – rescue by blocking 5‐ HT 2A receptors

Panzini, C. M., Ehlinger, D. G., Alchahin, A. M., Guo, Y., & Commons, K. G. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14227 · Cited by 20 · see citing works

Cav1.2 L-type calcium channels regulate stress coping behavior via serotonin neurons

Ehlinger, D. G., & Commons, K. G. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.033 · Cited by 20 · see citing works

Vortioxetine Reduces Marble Burying but Only Transiently Enhances Social Interaction Preference in Adult Male BTBR T+Itpr3tf/J Mice

Witt, N. A., Lee, B., Ghent, K., Zhang, W. Q., Pehrson, A. L., Sánchez, C., & Gould, G. G. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00386 · Cited by 20 · see citing works

Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism

Higuchi, Y., Tada, T., Nakachi, T., & Arakawa, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109634 · Cited by 18 · see citing works

Untargeted Metabolomic Analysis Reveals the Metabolic Disturbances and Exacerbation of Oxidative Stress in the Cerebral Cortex of a BTBR Mouse Model of Autism

Cao, C., Li, Q., Chen, Y., Zou, M., Sun, C., Li, X., & Wu, L. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02096-6 · Cited by 17 · see citing works

Citalopram attenuates social behavior deficits in the BTBR T+Itpr3tf/J mouse model of autism

Cai, Y., Wang, L. Y., Nalvarte, I., Xiao, R., Li, X., & Fan, X. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.04.026 · Cited by 16 · see citing works

Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance

Collins, S. M., O’Connell, C. J., Reeder, E. L., Norman, S. V., Lungani, K., Gopalan, P., Gudelsky, G. A., & Robson, M. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930346 · Cited by 15 · see citing works

Potential of cannabinoids as treatments for autism spectrum disorders

Nezgovorova, V., Ferretti, C. J., Taylor, B. P., Shanahan, E. C., Uzunova, G., Hong, K., Devinsky, O., & Hollander, E. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.048 · Cited by 15 · see citing works

Maternal LPS Exposure Enhances the 5-HT Level in the Prefrontal Cortex of Autism-like Young Offspring

Lin, F., Wang, X., Luo, R., Yuan, B., Ye, S., Yang, T., Xiao, L., & Chen, J. (2023) · Brain Sciences · doi:10.3390/brainsci13060958 · Cited by 12 · see citing works

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models

Sharghi, S., Flunkert, S., Daurer, M., Rabl, R., Chagnaud, B. P., Leopoldo, M., Lacivita, E., Hutter‐Paier, B., & Prokesch, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1087788 · Cited by 12 · see citing works

Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment

Martin, V., Mathieu, L., Díaz, J., Salman, H., Altério, J., Chevarin, C., Lanfumey, L., Hamon, M., Austin, M. C., Darmon, M. C., et al. (2020) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190134 · Cited by 11 · see citing works

Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities

Ehlinger, D. G., & Commons, K. G. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13707 · Cited by 11 · see citing works

Sex differences in the BTBR idiopathic mouse model of autism spectrum disorders: Behavioural and redox-related hippocampal alterations

Bové, M., Sikora, V., Santoro, M., Agosti, L. P., Palmieri, M. A., Dimonte, S., Tucci, P., Schiavone, S., Morgese, M. G., & Trabace, L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110134 · Cited by 10 · see citing works

Translational Magnetic Resonance Imaging in Autism Spectrum Disorder From the Mouse Model to Human

Tsurugizawa, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.872036 · Cited by 7 · see citing works

Association between maternal asthma and ASD/ADHD in offspring: A meta-analysis based on observational studies

Zheng, J., Chen, J., Zhang, Q., Ying, L., Huang, H., Yang, H. J., & Chen, Z. (2025) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-025-00440-y · Cited by 6 · see citing works

Treading water: mixed effects of high fat diet on mouse behavior in the forced swim test

Lloyd, K. R., & Reyes, T. M. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112965 · Cited by 5 · see citing works

Effects of the Cc2d1a/Freud-1 Knockdown in the Hippocampus of BTBR Mice on the Autistic-Like Behavior, Expression of Serotonin 5-HT1A and D2 Dopamine Receptors, and CREB and NF-kB Intracellular Signaling

Belokopytova, I. I., Kondaurova, E. M., Kulikova, E. A., Ilchibaeva, T. V., Naumenko, V. S., & Popova, N. K. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922100145 · Cited by 5 · see citing works

Calcitriol Modulates Hippocampal Axon Guidance Through Enhanced EfnA4 ‐Mediated PI3K / AKT Signaling in an Autism Mouse Model

Gong, T., Sun, R., Bai, J., Liu, X., He, C., Jiang, Q., Wang, Q., Qi, Y., Ding, W., Shen, J., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70429 · Cited by 4 · see citing works

Mechanisms of Valproic acid-Induced Autism: Canonical Wnt-β- Catenin Pathway

Elgamal, M., Moustafa, Y. M., Ali, A. A., El-Sayed, N. M., & Khodeer, D. M. (2023) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2023.189540.1205 · Cited by 4 · see citing works

What Gene Mutations Affect Serotonin in Mice?

Tenpenny, R. C., & Commons, K. G. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00441 · Cited by 3 · see citing works

Correlation studies on pathological changes in brain with neurotransmitters and behavioural changes in Balb/c mice

Balaji, G. K., Sinha, S. N., Surekha, M. V., Kasturi, V., Mungamuri, S. K., & Shashikala, P. (2022) · Journal of Environmental Biology · doi:10.22438/jeb/43/1/mrn-1863 · Cited by 3 · see citing works

Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder

Рожкова, И. Н., Okotrub, S. V., Brusentsev, E. Y., Uldanova, E. E., Chuyko, E. А., Lipina, T. V., Amstislavskaya, T. G., & Amstislavsky, S. Y. (2022) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-22-44 · Cited by 2 · see citing works

Circadian responses to non-photic treatments in BTBR mice

Shankara, J. V., Horsley, K. G., Jamani, N. F., Robinson, Z. A., Kwong, J. R. Y., & Antle, M. C. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114947 · Cited by 1 · see citing works

Context blindness in the BTBR T+ tf mouse model of autism: impaired contextual control of discrimination reversal learning

Kosaki, Y., & Mihara, R. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115752 · Cited by 1 · see citing works

ASD and ADHD as syndromes of high creativity - Le TSA et le TDAH comme syndromes de haute créativitéPreprint

Rebecchi, K. (2023) · doi:10.31234/osf.io/jerua · Cited by 1 · see citing works

Autism Spectrum Disorder: A Cross-cultural Variability in Personal Identity

Khan, A. A., & Ferrari, M. (2020) · Journal of the American Academy of Special Education Professionals · doi:10.64546/jaasep.439

Reflection on the future of autism research: the continuum hypothesis - Réflexion sur l'avenir de la recherche sur l'autisme : l'hypothèse du continuumPreprint

Rebecchi, K. (2023) · doi:10.31234/osf.io/egv2p

Maternal Exposure to Pm2.5 Impairs Behaviors and Hippocampal Plasticity in Association with Reduced Cysteine Levels in Adult OffspringPreprint

Zhong, Y., Ahadullah, Cheng, T., Rosa, J. M., Yang, Y., Zhao, D., Du, S., Lee, P. K. H., Akhlaq, H., Yu, J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6813049/v1

Reduced hippocampal cysteine levels in adult offspring is associated with hippocampal and behavioral impairments induced by maternal PM2.5 exposurePreprint

Yau, S., Zhong, Y. Y., Akhlaq, H., Tong, C., Ahadullah, Rosa, J., Zhao, D. D., Du, S., Lee, P. K. H., Yu, J., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-8854068/v1

Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism

Higuchi, Y., Tada, T., Nakachi, T., & Arakawa, H. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109634 · Cited by 18 · see citing works

Serotonin 5-HT1A, 5-HT2A, and 5-HT7 Receptors in the Brain of the BTBR Mouse the Model of Autism

Rodnyy, A. Y., Kulikova, E. A., Kondaurova, E. M., & Naumenko, V. S. (2021) · Neurochemical Journal · doi:10.1134/s1819712421010098 · Cited by 6 · see citing works

Influence of 5-HT1A receptors overexpression in the hippocampus on behavior and the brain serotonin system of BTBR mice – the model of autism

(2020) · Systems Biology and Bioinformatics International Young Scientists School (SBB) · doi:10.18699/sbb-2020-04

Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior

Gould, G. G., Hensler, J. G., Burke, T. F., Benno, R. H., Onaivi, E. S., & Daws, L. C. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07104.x · Cited by 138 · see citing works

Serotonin : from mouse models to human disorders

Jensen, A. L. (2014) · ScholarSpace (University of Hawaii at Manoa)