Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior
Open accessAbstract
Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The 5-HT transporter (SERT) gene ( SLC6A4 ) has been associated with whole blood 5-HT levels and ASD susceptibility. Previously, we identified multiple gain-of-function SERT coding variants in children with ASD. Here we establish that transgenic mice expressing the most common of these variants, SERT Ala56, exhibit elevated, p38 MAPK-dependent transporter phosphorylation, enhanced 5-HT clearance rates and hyperserotonemia. These effects are accompanied by altered basal firing of raphe 5-HT neurons, as well as 5HT 1A and 5HT 2A receptor hypersensitivity. Strikingly, SERT Ala56 mice display alterations in social function, communication, and repetitive behavior. Our efforts provide strong support for the hypothesis that altered 5-HT homeostasis can impact risk for ASD traits and provide a model with construct and face validity that can support further analysis of ASD mechanisms and potentially novel treatments.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mice expressing a gain-of-function SERT variant that decreases 5-HT levels exhibit altered basal firing of DR 5-HT neurons.
“as well as altered basal firing of DR 5-HT neurons [120,121].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [120]
Mice expressing a gain-of-function SERT variant that decreases 5-HT levels exhibit impaired sociability.
“mice expressing a gain-of-function SERT variant that decreases 5-HT levels exhibit impaired sociability”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [120]
SERT Ala56 mice exhibit whole-blood hyperserotonemia.
“SERT Ala56 mice exhibit whole-blood hyperserotonemia as well as brain and behavioral anomalies”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [55]
SERT Ala56 mice exhibit behavioral anomalies emulating those in ASD, including repetitive behaviors, delayed communication and deficits in social interactions.
“behavioral anomalies emulating those in ASD including repetitive behaviors, delayed communication and deficits in social interactions [55].”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [55]
SERT Ala56 mice exhibit increased 5-HT clearance in the CNS and hypersensitivity of CNS 5-HT1A and 5-HT2A receptors.
“including increased 5-HT clearance in the CNS, hypersensitivity of CNS 5-HT1A and 5-HT2A receptors”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., & Gouaux, E. (2005) · Nature · doi:10.1038/nature03978 · Cited by 1,660 · see citing works
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570 · see citing works
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · see citing works
Self-citationBehavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Self-citationPeñagarikano, O., Abrahams, B. S., Herman, E. I., Winden, K. D., Gdalyahu, A., Dong, H., Sonnenblick, L. I., Gruver, R., Almajano, J., Bragin, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.040 · Cited by 1,075 · see citing works
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997 · see citing works
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works
Extracellular space structure revealed by diffusion analysis
Nicholson, C., & Syková, E. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01261-2 · Cited by 914 · see citing works
Ramamoorthy, S., Bauman, A. L., Moore, K. R., Han, H. J., Yang‐Feng, T. L., Chang, A. S., Ganapathy, V., & Blakely, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2542 · Cited by 880 · see citing works
Self-citationEarly-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works
Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety
Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L. A., & Paylor, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1466-y · Cited by 698 · see citing works
A transient placental source of serotonin for the fetal forebrain
Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., & Levitt, P. (2011) · Nature · doi:10.1038/nature09972 · Cited by 608 · see citing works
Self-citationLanda, R. J., Holman, K. C., & Garrett-Mayer, E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.853 · Cited by 590 · see citing works
Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children
Schain, R. J., & Freedman, D. X. (1961) · The Journal of Pediatrics · doi:10.1016/s0022-3476(61)80261-8 · Cited by 579 · see citing works
Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556 · see citing works
Lucki, I., Dalvi, A., & Mayorga, A. J. (2001) · Psychopharmacology · doi:10.1007/s002130100694 · Cited by 506 · see citing works
A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p
(2001) · The American Journal of Human Genetics · doi:10.1086/323264 · Cited by 453 · see citing works
Etherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910297106 · Cited by 447 · see citing works
Chen, J. C., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., & Gershon, M. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06348.2001 · Cited by 397 · see citing works
Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., McCauley, J. L., Han, Q., Jiang, L., Li, C., Folstein, S. E., & Blakely, R. D. (2005) · The American Journal of Human Genetics · doi:10.1086/432648 · Cited by 392 · see citing works
Self-citationMiyakawa, T., Yamada, M., Duttaroy, A., & Wess, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05239.2001 · Cited by 366 · see citing works
Sensorimotor gating deficits in adults with autism
Perry, W., Minassian, A., Lopez, B., Maron, L., & Lincoln, A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.025 · Cited by 352 · see citing works
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
Moretti, P. M., Bouwknecht, J. A., Teague, R. M., Paylor, R. E., & Zoghbi, H. Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi016 · Cited by 343 · see citing works
Salichon, N., Gaspar, P., Upton, A. L., Picaud, S., Hanoun, N., Hamon, M., Maeyer, E. D., Murphy, D. L., Mößner, R., Lesch, K., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00884.2001 · Cited by 265 · see citing works
Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
Bonnin, A., Torii, M., Wang, L., RAKIC, P. T., & Levitt, P. R. (2007) · Nature Neuroscience · doi:10.1038/nn1896 · Cited by 249 · see citing works
Social approach in genetically engineered mouse lines relevant to autism
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., & Lauder, J. M. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00452.x · Cited by 246 · see citing works
Self-citationWillins, D. L., & Meltzer, H. Y. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36840-5 · Cited by 244 · see citing works
Bauman, A. L., Apparsundaram, S., Ramamoorthy, S., Wadzinski, B. E., Vaughan, R. A., & Blakely, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07571.2000 · Cited by 235 · see citing works
Self-citationA genetic approach to access serotonin neurons for in vivo and in vitro studies
Scott, M. M., Wylie, C. J., Lerch, J. K., Murphy, R., Lobur, K. J., Herlitze, S., Jiang, W., Conlon, R. A., Strowbridge, B. W., & Deneris, E. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504510102 · Cited by 233 · see citing works
Samuvel, D. J., Jayanthi, L. D., Bhat, N. R., & Ramamoorthy, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3754-04.2005 · Cited by 215 · see citing works
Self-citationBoyce‐Rustay, J. M., & Holmes, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301039 · Cited by 209 · see citing works
Mulder, E. J., Anderson, G. M., Kema, I. P., de Bildt, A., van Lang, N. D., den Boer, J. A., & Minderaa, R. B. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200404000-00016 · Cited by 199 · see citing works
Autism and the serotonin transporter: the long and short of it
Devlin, B., Cook, E. H., Coon, H. H., Dawson, G., Grigorenko, E. L., McMahon, W., Minshew, N. J., Pauls, D. L., Smith, M., Spence, M. A., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001724 · Cited by 187 · see citing works
Anderson, G. M., Feibel, F. C., & Cohen, D. J. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90568-6 · Cited by 185 · see citing works
Steele, A. D., Jackson, W. S., King, O. D., & Lindquist, S. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610779104 · Cited by 181 · see citing works
Prasad, H. C., Zhu, C.-B., McCauley, J. L., Samuvel, D. J., Ramamoorthy, S., Shelton, R. C., Hewlett, W. A., Sutcliffe, J. S., & Blakely, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501432102 · Cited by 180 · see citing works
Self-citationCarneiro, A. M. D., Cook, E. H., Murphy, D. L., & Blakely, R. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33374 · Cited by 180 · see citing works
Self-citationA Principal Components Analysis of the Autism Diagnostic Interview-Revised
Tadevosyan-leyfer, O., Dowd, M., Mankoski, R., Winklosky, B., Putnam, S., McGrath, L., Tager-flusberg, H., & Folstein, S. E. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046870.56865.90 · Cited by 173 · see citing works
Zhu, C.-B., Hewlett, W. A., Feoktistov, I., Biaggioni, I., & Blakely, R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1462 · Cited by 168 · see citing works
Self-citationBroad and narrow heritabilities of quantitative traits in a founder population
Abney, M., McPeek, M. S., & Ober, C. (2001) · The American Journal of Human Genetics · doi:10.1086/320112 · Cited by 157 · see citing works
Glatt, C. E., DeYoung, J. A., Delgado, S., Service, S. K., Giacomini, K. M., Edwards, R. H., Risch, N., & Freimer, N. B. (2001) · Nature Genetics · doi:10.1038/86948 · Cited by 154 · see citing works
Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits
Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Bécamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.016 · Cited by 145 · see citing works
Riccio, O., Potter, G., Walzer, C., Vallet, P., Szabó, G., Vutskits, L., Kiss, J. Z., & Dayer, A. G. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.89 · Cited by 138 · see citing works
A Quantitative Trait Locus Analysis of Social Responsiveness in Multiplex Autism Families
Duvall, J. A., Lu, A. T.-H., Cantor, R. M., Todd, R. D., Constantino, J. N., & Geschwind, D. H. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.656 · Cited by 138 · see citing works
Sex-specific genetic architecture of whole blood serotonin levels
Weiss, L. A., Abney, M., Cook, E. H., & Ober, C. (2005) · The American Journal of Human Genetics · doi:10.1086/426697 · Cited by 137 · see citing works
Going with the Flow: Trafficking‐Dependent and ‐Independent Regulation of Serotonin Transport
Steiner, J. A., Carneiro, A. M. D., & Blakely, R. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00757.x · Cited by 127 · see citing works
Self-citationEnhanced activity of human serotonin transporter variants associated with autism
Prasad, H. C., Steiner, J. A., Sutcliffe, J. S., & Blakely, R. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0143 · Cited by 126 · see citing works
Self-citationPostnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117 · see citing works
Self-citationPrincipal pathogenetic components and biological endophenotypes in autism spectrum disorders
Sacco, R., Curatolo, P., Manzi, B., Militerni, R., Bravaccio, C., Frolli, A., Lenti, C., Saccani, M., Elia, M., Reichelt, K.-L., et al. (2010) · Autism Research · doi:10.1002/aur.151 · Cited by 102 · see citing works
Ramamoorthy, S., Samuvel, D. J., Buck, E. R., Rudnick, G., & Jayanthi, L. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611353200 · Cited by 100 · see citing works
Self-citationNunemaker, C. S., DeFazio, R. A., & Moenter, S. M. (2003) · Biological Procedures Online · doi:10.1251/bpo46 · Cited by 99 · see citing works
Subcellular Redistribution of the Serotonin Transporter by Secretory Carrier Membrane Protein 2
Müller, H. K., Wiborg, O., & Haase, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602848200 · Cited by 91 · see citing works
Wischmeyer, E., & Karschin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5819 · Cited by 90 · see citing works
5‐HT1B Receptor‐Mediated Regulation of Serotonin Clearance in Rat Hippocampus In Vivo
Daws, L. C., Gould, G. G., Teicher, S., Gerhardt, G. A., & Frazer, A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752113.x · Cited by 83 · see citing works
Self-citationAdkins, E. M., Barker, E. L., & Blakely, R. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.514 · Cited by 77 · see citing works
Self-citationA pharmacological analysis of mice with a targeted disruption of the serotonin transporter
Fox, M. A., Andrews, A. M., Wendland, J. R., Lesch, K., Holmes, A., & Murphy, D. L. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0910-0 · Cited by 71 · see citing works
Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
Weiss, L. A., Veenstra-VanderWeele, J. M., Newman, D. L., Kim, S., Dytch, H. E., McPeek, M. S., Cheng, S., Ober, C., Cook, E. H., & Abney, M. (2004) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201239 · Cited by 68 · see citing works
Self-citationPrasad, P. D., Hoffmans, B. J., Moe, A. J., Smith, C. H., Leibach, F. H., & Ganapathy, V. (1996) · Placenta · doi:10.1016/s0143-4004(96)90039-9 · Cited by 59 · see citing works
Relationship between whole blood serotonin and repetitive behaviors in autism
Kolevzon, A., Newcorn, J. H., Kryzak, L., Chaplin, W., Watner, D., Hollander, E., Smith, C. J., Cook, E. H., & Silverman, J. M. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.02.008 · Cited by 50 · see citing works
Steiner, J. A., Carneiro, A. M., Wright, J., Matthies, H. J. G., Prasad, H. C., Nicki, C. K., Dostmann, W. R., Buchanan, C. C., Corbin, J. D., Francis, S. H., et al. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-26 · Cited by 48 · see citing works
Self-citationBazalakova, M. H., Wright, J. R., Schneble, E. J., McDonald, M. P., Heilman, C. J., Levey, A. I., & Blakely, R. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00269.x · Cited by 47 · see citing works
Self-citationJennings, K. A., Sheward, W. J., Harmar, A. J., & Sharp, T. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.12.001 · Cited by 47 · see citing works
Evans, A. K., Reinders, N. R., Ashford, K. A., Christie, I. N., Wakerley, J. B., & Lowry, C. A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.014 · Cited by 42 · see citing works
Veenstra-VanderWeele, J. M., Jessen, T. N., Thompson, B. J., Carter, M. D., Prasad, H. C., Steiner, J. A., Sutcliffe, J. S., & Blakely, R. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9020-0 · Cited by 42 · see citing works
Self-citationCiccone, M. A., Timmons, M., Phillips, A., & Quick, M. W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.018 · Cited by 42 · see citing works
Daws, L. C., Toney, G. M., Davis, D. J., Gerhardt, G. A., & Frazer, A. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00144-1 · Cited by 40 · see citing works
Self-citationRusyniak, D. E., Zaretskaia, M. V., Zaretsky, D. V., & DiMicco, J. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.126169 · Cited by 35 · see citing works
A large‐scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders
Sakurai, T., Reichert, J. G., Hoffman, E. J., Cai, G., Jones, H. B., Faham, M., & Buxbaum, J. D. (2008) · Autism Research · doi:10.1002/aur.30 · Cited by 22 · see citing works
Binda, F., Lute, B. J., Dipace, C., Blakely, R., & Galli, A. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.09.012 · Cited by 15 · see citing works
Self-citationVisually Guided Patch-Clamp Recordings in Brain Slices
Moyer, J. R., & Brown, T. H. (2007) · Neuromethods · doi:10.1007/978-1-59745-492-6_6 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The bowel and beyond: The enteric nervous system in neurological disorders
Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629 · see citing works
The serotonin system in autism spectrum disorder: From biomarker to animal models
Muller, C. L., Anacker, A. M. J., & Veenstra-VanderWeele, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.010 · Cited by 531 · see citing works
Self-citationThe Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works
Wang, H., Xu, J., Lazarovici, P., Quirion, R., & Zheng, W. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00255 · Cited by 433 · see citing works
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
Roullet, F., Lai, J., & Foster, J. A. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.01.004 · Cited by 425 · see citing works
Baum, S. H., Stevenson, R. A., & Wallace, M. T. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.007 · Cited by 370 · see citing works
Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis
Gabriele, S., Sacco, R., & Persico, A. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.004 · Cited by 346 · see citing works
Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., Loth, E., McAlonan, G. M., McCracken, J. T., Parr, J. R., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117741766 · Cited by 342 · see citing works
Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321 · see citing works
A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin
Baganz, N. L., & Blakely, R. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300186b · Cited by 308 · see citing works
Self-citationAltered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works
Samsel, A., & Seneff, S. (2013) · Entropy · doi:10.3390/e15041416 · Cited by 293 · see citing works
Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder
Eissa, N., Al‐Houqani, M., Sadeq, A. S., Ojha, S. K., Sasse, A., & Sadek, B. S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00304 · Cited by 263 · see citing works
5-HT release in nucleus accumbens rescues social deficits in mouse autism model
Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., Deisseroth, K., & Malenka, R. C. (2018) · Nature · doi:10.1038/s41586-018-0416-4 · Cited by 256 · see citing works
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works
Gastrointestinal issues in autism spectrum disorder
Hsiao, E. Y. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000029 · Cited by 209 · see citing works
Disorders of the enteric nervous system — a holistic view
Niesler, B., Küerten, S., Demir, İ. E., & Schäfer, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00385-2 · Cited by 198 · see citing works
Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance
Terry, N. A., & Margolis, K. G. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_103 · Cited by 194 · see citing works
Tyszka, J. M., Kennedy, D. P., Paul, L. K., & Adolphs, R. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht040 · Cited by 187 · see citing works
Behavioral phenotypes of genetic mouse models of autism
Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 179 · see citing works
Self-citationTye, C., Runicles, A. K., Whitehouse, A. J. O., & Alvares, G. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00751 · Cited by 177 · see citing works
Rudnick, G., Krämer, R., Blakely, R., Murphy, D. L., & Verrey, F. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1410-1 · Cited by 166 · see citing works
Self-citationAutism-Relevant Social Abnormalities and Cognitive Deficits in Engrailed-2 Knockout Mice
Brielmaier, J. M., Matteson, P. G., Silverman, J. L., Senerth, J. M., Kelly, S., Genestine, M., Millonig, J. H., DiCicco-Bloom, E. M., & Crawley, J. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040914 · Cited by 156 · see citing works
Self-citationDeveloping zebrafish models of autism spectrum disorder (ASD)
Stewart, A., Nguyen, M., Wong, K., Poudel, M. K., & Kalueff, A. V. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.014 · Cited by 151 · see citing works
Pretzsch, C. M., Freyberg, J., Voinescu, B., Lythgoe, D. J., Horder, J., Méndez, M. A., Wichers, R., Ajram, L. A., Ivin, G., Heasman, M., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0333-8 · Cited by 156 · see citing works
Kim, H., Lim, C., & Kaang, B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0087-y · Cited by 146 · see citing works
Kane, M. J., Angoa‐Pérez, M., Briggs, D. I., Sykes, C. E., Francescutti, D. M., Rosenberg, D. R., & Kuhn, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048975 · Cited by 140 · see citing works
Margolis, K. G., Li, Z., Stevanovic, K., Saurman, V., Israelyan, N., Anderson, G. M., Snyder, I., Veenstra-VanderWeele, J., Blakely, R. D., & Gershon, M. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84877 · Cited by 139 · see citing works
Self-citationExploring sleep quality of young children with autism spectrum disorder and disruptive behaviors
Johnson, C. R., Smith, T. H., DeMand, A., Lecavalier, L., Evans, V., Gurka, M. J., Swiezy, N. B., Bearss, K. E., & Scahill, L. D. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.01.008 · Cited by 140 · see citing works
Woodward, N. D., Giraldo‐Chica, M., Rogers, B. P., & Cascio, C. J. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.09.002 · Cited by 136 · see citing works
Yang, C.-J., Tan, H.-P., & Du, Y.-J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.021 · Cited by 132 · see citing works
Malynn, S., Campos‐Torres, A., Moynagh, P. N., & Haase, J. K. (2013) · Neurochemical Research · doi:10.1007/s11064-012-0967-y · Cited by 125 · see citing works
Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
Israelyan, N., & Margolis, K. G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.020 · Cited by 122 · see citing works
Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120 · see citing works
Genetic and non-genetic animal models for autism spectrum disorders (ASD)
Ergaz, Z., Weinstein‐Fudim, L., & Ornoy, A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.04.024 · Cited by 116 · see citing works
Monoamine oxidase A and A/B knockout mice display autistic-like features
Bortolato, M., Godar, S. C., Alzghoul, L., Zhang, J., Darling, R. D., Simpson, K. L., Bini, V., Chen, K., Wellman, C. L., Lin, R. C. S., et al. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000715 · Cited by 118 · see citing works
Sleep in Autism Spectrum Disorders
Veatch, O. J., Maxwell-Horn, A. C., & Malow, B. A. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-015-0012-1 · Cited by 114 · see citing works
Drosophila melanogaster as a genetic model system to study neurotransmitter transporters
Martin, C. A., & Krantz, D. E. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.015 · Cited by 113 · see citing works
Functional significance of rare neuroligin 1 variants found in autism
Nakanishi, M., Nomura, J., Ji, X., Tamada, K., Arai, T., Takahashi, E., Bućan, M., & Takumi, T. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006940 · Cited by 112 · see citing works
Ciranna, L., & Catania, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00250 · Cited by 102 · see citing works
Enteric Neuronal Regulation of Intestinal Inflammation
Margolis, K. G., & Gershon, M. D. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.06.007 · Cited by 110 · see citing works
Tian, J., Gao, X., & Yang, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.780407 · Cited by 125 · see citing works
Pretzsch, C. M., Voinescu, B., Méndez, M. A., Wichers, R., Ajram, L. A., Ivin, G., Heasman, M., Williams, S., Murphy, D., Daly, E., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119858306 · Cited by 107 · see citing works
Serotonin neuron development: shaping molecular and structural identities
Deneris, E. S., & Gaspar, P. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.301 · Cited by 109 · see citing works
Intestinal inflammation in a murine model of autism spectrum disorders
de Theije, C. G. M., Koelink, P. J., Korte-Bouws, G. A. H., da Silva, S. L., Korte, S. M., Olivier, B., Garssen, J., & Kraneveld, A. D. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.004 · Cited by 100 · see citing works
Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters
Bermingham, D. P., & Blakely, R. D. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012260 · Cited by 97 · see citing works
Self-citationGuo, M., Zhu, J., Yang, T., Lai, X., Liu, X., Liu, J., Chen, J., & Li, T. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.11.001 · Cited by 97 · see citing works
Hung, L. Y., & Margolis, K. G. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00857-1 · Cited by 96 · see citing works
Robson, M. J., Quinlan, M. A., & Blakely, R. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00412 · Cited by 95 · see citing works
Self-citationWnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind
Bem, J., Brożko, N., Chakraborty, C., Lipiec, M. A., Koziński, K., Nagalski, A., Szewczyk, Ł. M., & Wisniewska, M. B. (2019) · FEBS Letters · doi:10.1002/1873-3468.13502 · Cited by 94 · see citing works
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 94 · see citing works
Walker, C. K., Anderson, K. W., Milano, K. M., Ye, S., Tancredi, D. J., Pessah, I. N., Hertz‐Picciotto, I., & Kliman, H. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.006 · Cited by 92 · see citing works
Watson, K. K., & Platt, M. L. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-21 · Cited by 90 · see citing works
Dougherty, J. D., Maloney, S. E., Wozniak, D. F., Rieger, M. A., Sonnenblick, L. I., Coppola, G., Mahieu, N. G., Zhang, J., Cai, J., Patti, G. J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4762-12.2013 · Cited by 86 · see citing works
Caruso, A., Ricceri, L., & Scattoni, M. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.011 · Cited by 85 · see citing works
Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
Israelyan, N., & Margolis, K. G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.023 · Cited by 87 · see citing works
Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link
Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M., & Homberg, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165850 · Cited by 86 · see citing works
Lim, J. S., Lim, M. Y., Choi, Y., & Ko, G. (2017) · Molecular Brain · doi:10.1186/s13041-017-0292-0 · Cited by 85 · see citing works
The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder
Chernikova, M. A., Flores, G. D., Kilroy, E., Labus, J. S., Mayer, E. A., & Aziz‐Zadeh, L. (2021) · Nutrients · doi:10.3390/nu13124497 · Cited by 86 · see citing works
Bipolar disorder in adults with Asperger׳s Syndrome: A systematic review
Vannucchi, G., Masi, G., Toni, C., Dell’Osso, L., Erfurth, A., & Perugi, G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.042 · Cited by 89 · see citing works
Garbarino, V. R., Gilman, T. L., Daws, L. C., & Gould, G. G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.07.010 · Cited by 83 · see citing works
Self-citationAutism Biomarkers: Challenges, Pitfalls and Possibilities
Anderson, G. M. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2225-4 · Cited by 82 · see citing works
Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W., Pittman, J. T., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.013 · Cited by 83 · see citing works
The combined role of serotonin and interleukin-6 as biomarker for autism
Yang, C.-J., Liu, C.-L., Sang, B., Zhu, X.-M., & Du, Y.-J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.011 · Cited by 80 · see citing works
Serotonin and serotonin transporter levels in autistic children
Abdulamir, H. A., Abdul‐Rasheed, O. F., & Abdulghani, E. A. (2018) · Saudi Medical Journal · doi:10.15537/smj.2018.5.21751 · Cited by 80 · see citing works
Amodeo, D. A., Jones, J. H., Sweeney, J. A., & Ragozzino, M. E. (2014) · Autism Research · doi:10.1002/aur.1395 · Cited by 79 · see citing works
Ali, E. H. A., & Elgoly, A. H. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.016 · Cited by 79 · see citing works
Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin
Mosienko, V., Beis, D. M., Alenina, N. V., & Wöhr, M. (2015) · Molecular Autism · doi:10.1186/s13229-015-0003-6 · Cited by 79 · see citing works
Chang, J. C., Tomlinson, I. D., Warnement, M. R., Ustione, A., Carneiro, A. M. D., Piston, D. W., Blakely, R., & Rosenthal, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0048-12.2012 · Cited by 78 · see citing works
Self-citationPhotoperiod Programs Dorsal Raphe Serotonergic Neurons and Affective Behaviors
Green, N. H., Jackson, C. R., Iwamoto, H., Tackenberg, M. C., & McMahon, D. G. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.050 · Cited by 73 · see citing works
Self-citationMuller, C. L., Anacker, A. M. J., Rogers, T. D., Goeden, N., Keller, E. H., Forsberg, C. G., Kerr, T. M., Wender, C. L. A., Anderson, G. M., Stanwood, G. D., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.166 · Cited by 76 · see citing works
Self-citationMergy, M. A., Gowrishankar, R., Gresch, P. J., Gantz, S. C., Williams, J. T., Davis, G. L., Wheeler, C. A., Stanwood, G. D., Hahn, M. K., & Blakely, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417294111 · Cited by 69 · see citing works
Self-citationNeural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
Biomarkers for Psychiatric Disorders: Where Are We Standing?
Martins‐de‐Souza, D. (2013) · Disease Markers · doi:10.1155/2013/321071 · Cited by 73 · see citing works
Kim, B. S., Lee, J., Bang, M., Seo, B. A., Khalid, A., Jung, M. W., & Jeon, D. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3581-7 · Cited by 65 · see citing works
Chen, X., Ye, R., Gargus, J. J., Blakely, R., Dobrenis, K., & Sze, J. Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.033 · Cited by 65 · see citing works
Self-citationTargets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions
Lacivita, E., Perrone, R., Margari, L., & Leopoldo, M. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00965 · Cited by 66 · see citing works
Serotonin transporter availability in adults with autism—a positron emission tomography study
Andersson, M., Tangen, Ä., Farde, L., Bölte, S., Halldin, C., Borg, J., & Lundberg, J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00868-3 · Cited by 64 · see citing works
Lorsung, E., Ramanujam, K., & Cao, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.642745 · Cited by 63 · see citing works
Novel aspects of enteric serotonergic signaling in health and brain-gut disease
Colle, A. D., Israelyan, N., & Margolis, K. G. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2019 · Cited by 65 · see citing works
Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test
Arrant, A. E., Filiano, A. J., Warmus, B. A., Hall, A. M., & Roberson, E. D. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12300 · Cited by 60 · see citing works
The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders
Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 63 · see citing works
Moya, P. R., Wendland, J. R., Rubenstein, L. M., Timpano, K. R., Heiman, G. A., Tischfield, J. A., King, R. A., Andrews, A. M., Ramamoorthy, S., McMahon, F. J., et al. (2013) · Movement Disorders · doi:10.1002/mds.25460 · Cited by 57 · see citing works
Self-citationChen, R., Davis, L. K., Guter, S. J., Wei, Q., Jacob, S., Potter, M. H., Cox, N. J., Cook, E. H., Sutcliffe, J. S., & Li, B. (2017) · Molecular Autism · doi:10.1186/s13229-017-0130-3 · Cited by 57 · see citing works
Self-citationEnhanced Aggressive Behaviour in a Mouse Model of Depression
Yang, C., Bai, Y., Ruan, C., Zhou, H., Liu, D., Wang, X., Shen, L., Zheng, H. Y., & Zhou, X. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9498-4 · Cited by 58 · see citing works
Robson, M. J., Quinlan, M. A., Margolis, K. G., Gajewski-Kurdziel, P. A., Veenstra-VanderWeele, J. M., Gershon, M. D., Watterson, D. M., & Blakely, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809137115 · Cited by 57 · see citing works
Self-citationGastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1 +/− mice
Fröhlich, H., Kollmeyer, M. L., Linz, V. C., Stuhlinger, M., Groneberg, D., Reigl, A., Zizer, E., Friebe, A., Niesler, B., & Rappold, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911429116 · Cited by 57 · see citing works
Walsh, J. J., Llorach, P., Cardozo Pinto, D. F., Wenderski, W., Christoffel, D. J., Salgado, J. S., Heifets, B. D., Crabtree, G. R., & Malenka, R. C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01091-6 · Cited by 56 · see citing works
Zhang, W. Q., Smolik, C. M., Barba-Escobedo, P. A., Gamez, M., Sanchez, J. J., Javors, M. A., Daws, L. C., & Gould, G. G. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.024 · Cited by 56 · see citing works
Self-citationMechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter
Davis, B. A., Nagarajan, A., Forrest, L. R., & Singh, S. K. (2016) · Scientific Reports · doi:10.1038/srep23789 · Cited by 56 · see citing works
Rose’Meyer, R. B. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-37 · Cited by 56 · see citing works
5HT2A receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice
Amodeo, D. A., Rivera, E., Cook, E. H., Sweeney, J. A., & Ragozzino, M. E. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12343 · Cited by 55 · see citing works
Yang, E.-J., Ahn, S., Lee, K., Mahmood, U., & Kim, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153298 · Cited by 54 · see citing works
Toward manipulating serotonin signaling via the microbiota–gut–brain axis
Everett, B. A., Tran, P., & Prindle, A. B. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102826 · Cited by 52 · see citing works
An autism-associated serotonin transporter variant disrupts multisensory processing
Siemann, J. K., Muller, C. L., Forsberg, C. G., Blakely, R., Veenstra-VanderWeele, J. M., & Wallace, M. T. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.17 · Cited by 52 · see citing works
Self-citationBhat, S., El‐Kasaby, A., Freissmuth, M., & Sučić, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107785 · Cited by 53 · see citing works
Serotonin neuron abnormalities in the BTBR mouse model of autism
Guo, Y., & Commons, K. G. (2017) · Autism Research · doi:10.1002/aur.1665 · Cited by 51 · see citing works
Farook, M. F., DeCuypere, M. G., Hyland, Κ., Takumi, T., LeDoux, M. S., & Reiter, L. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043030 · Cited by 49 · see citing works
Mahmood, U., Ahn, S., Yang, E.-J., Choi, M., Kim, H.-J., Regan, P. L., Cho, K., & Kim, H.-S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.006 · Cited by 52 · see citing works
Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder
Bjørklund, G., Meguid, N. A., El-Ansary, A. K., El‐Bana, M. A., Dadar, M., Aaseth, J., Hemimi, M., Osredkar, J., & Chirumbolo, S. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1192-1 · Cited by 51 · see citing works
- Authors
- Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., Ye, R., Kerr, T. M., Carneiro, A. M., Crawley, J. N., Sanders-Bush, E., McMahon, D. G., Ramamoorthy, S., Daws, L. C., Sutcliffe, J. S., & Blakely, R. D.
- Affiliations
- Vanderbilt University (US)
- The University of Texas at San Antonio Health Science Center (US)
- National Institutes of Health (US)
- Departments of aPsychiatry,
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-03-19
- Volume
- 109
- Issue
- 14
- Pages
- 5469-5474
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3325657
- OpenAlex
- W2104220482
- Cited by
- 333
- References
- 76
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 18 · 2023: 17 · 2022: 21 · 2021: 26 · 2020: 20 · 2019: 25 · 2018: 23 · 2017: 27 · 2016: 33 · 2015: 23 · 2014: 29 · 2013: 33 · 2012: 18
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Autism Speaks (AS2429)
- Vanderbilt University (HD15052)
- Vanderbilt Institute for Clinical and Translational Research (RR024975)
- H. Lundbeck A/S
- National Institutes of Health (HD-15052, RR024975)
- Vanderbilt Kennedy Center, Vanderbilt University Medical Center
- National Institute of Mental Health (R01MH094527, K08MH081066, MH081066, MH078098, R01MH062612, MH094604, MH-62612, R01MH094604, R03MH078098)
- National Institute on Drug Abuse (DA-07390, R01DA007390)
- National Center for Research Resources (RR024975, KL2RR024977, TL1RR024978, UL1RR024975)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052, HD 15052, HD065278, R01HD065278)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- autism spectrum disorder, hyperserotonemia, serotonin transporter, gain-of-function mutations, p38 MAPK, serotonin clearance, raphe neurons, 5-HT1A receptor, 5-HT2A receptor, receptor hypersensitivity, social dysfunction, repetitive behavior, transgenic mouse model
- MeSH terms
- Animals, Autistic Disorder, Disease Models, Animal, Homeostasis, Receptors, Serotonin, Serotonin, Social Behavior, Stereotyped Behavior, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review