Cited by 133RNA Research and SplicingRNA and protein synthesis mechanismsCancer-related molecular mechanisms research

Introns in UTRs: why we should stop ignoring them

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Bicknell, Alicia A., Cenik, Can, Chua, Hon N., Roth, Frederick P., Moore, Melissa J.·2012·BioEssays

Abstract

Although introns in 5′‐ and 3′‐untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3′‐UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense‐mediated decay (NMD). Nonetheless, recent findings indicate that 5′‐ and 3′‐UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.

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Authors
Bicknell, A. A., Cenik, C., Chua, H. N., Roth, F. P., & Moore, M. J.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • University of Toronto (CA)
  • Howard Hughes Medical Institute (US)
Corresponding author
Moore, Melissa J.
Venue
BioEssays
Publisher
Wiley
Published
2012-10-26
Volume
34
Issue
12
Pages
1025-1034
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2134586803
Cited by
133
References
85
Citations by year
2026: 6 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 14 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 9
FWCI
0.90
Type
journal article
Language
en
Open access
Locations
  • BioEssays (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
introns, untranslated regions, nonsense-mediated mRNA decay, gene expression regulation, transcript splicing, non-coding RNA
MeSH terms
Animals, Gene Expression Regulation, Humans, Introns, Organ Specificity, Ribonucleoproteins, RNA, Messenger, 5' Untranslated Regions, 3' Untranslated Regions, Nonsense Mediated mRNA Decay

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