Introns in UTRs: why we should stop ignoring them
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Although introns in 5′‐ and 3′‐untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3′‐UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense‐mediated decay (NMD). Nonetheless, recent findings indicate that 5′‐ and 3′‐UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.
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IR has been overlooked as a means of normal gene regulation.
“As a result, IR has been overlooked as a means of normal gene regulation (Bicknell et al., 2012; Hillman et al., 2004”
From Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation (2013) · cites this paper as Bicknell et al., 2012
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- Authors
- Bicknell, A. A., Cenik, C., Chua, H. N., Roth, F. P., & Moore, M. J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- University of Toronto (CA)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Moore, Melissa J.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2012-10-26
- Volume
- 34
- Issue
- 12
- Pages
- 1025-1034
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2134586803
- Cited by
- 133
- References
- 85
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 14 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 9
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BioEssays (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- introns, untranslated regions, nonsense-mediated mRNA decay, gene expression regulation, transcript splicing, non-coding RNA
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Introns, Organ Specificity, Ribonucleoproteins, RNA, Messenger, 5' Untranslated Regions, 3' Untranslated Regions, Nonsense Mediated mRNA Decay
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