Cited by 408Genomics and Chromatin DynamicsRNA Research and SplicingCancer-related molecular mechanisms research

The functional consequences of alternative promoter use in mammalian genomes

Davuluri, Ramana V., Suzuki, Yutaka, Sugano, Sumio, Plass, Christoph, Huang, Tim H.-M.·2008·Trends in Genetics

Abstract

We are beginning to appreciate the increasing complexity of mammalian gene structure. A phenomenon that adds an important dimension to this complexity is the use of alternative gene promoters that drive widespread cell type, tissue type or developmental gene regulation. Recent annotations of the human genome suggest that almost one half of the protein-coding genes contain alternative promoters, including those of many disease-associated genes. Aberrant use of one promoter over another has been found to be associated with various diseases, including cancer. Here we discuss the functional consequences of use and misuse of alternative promoters in normal and disease genomes and review the molecular mechanisms regulating alternative promoter use in mammalian genomes.

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Crossref · 10.1016/j.tig.2008.01.008

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  • Almost half of the known protein-coding genes in humans utilize alternative promoters.

    “In addition to alternative splicing, almost half of the known protein-coding genes in humans utilize alternative promoters.”

    From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Davuluri et al., 2008

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Authors
Davuluri, R. V., Suzuki, Y., Sugano, S., Plass, C., & Huang, T. H.-M.
Affiliations
  • The Wistar Institute (US)
  • The University of Tokyo (JP)
  • German Cancer Research Center (DE)
  • The Ohio State University (US)
Corresponding author
Davuluri, Ramana V.
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2008-04
Volume
24
Issue
4
Pages
167-177
ISSN
0168-9525 (ISSN-L)
OpenAlex
W2094074349
Cited by
408
References
114
Citations by year
2026: 18 · 2025: 17 · 2024: 19 · 2023: 31 · 2022: 15 · 2021: 32 · 2020: 33 · 2019: 24 · 2018: 20 · 2017: 25 · 2016: 18 · 2015: 18 · 2014: 12 · 2013: 25 · 2012: 22
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Leukemia and Lymphoma Society
  • National Human Genome Research Institute (R01HG003362)
  • National Cancer Institute (P01CA101956, CA 101956, U54CA113001)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
alternative splicing, gene expression regulation, disease-associated genes, cancer, tissue-specific gene regulation, developmental gene regulation, human genome annotation
MeSH terms
Animals, Humans, Promoter Regions, Genetic, Transcription, Genetic, Genome, Genomic Imprinting, Protein Isoforms, 5' Untranslated Regions

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