The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
LINE-1 retrotransposons: Modulators of quantity and quality of mammalian gene expression?
Abstract
LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2, an endonuclease/reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious function of self-replication, it is not clear what other roles, if any, L1 plays within its host. The sheer magnitude of L1 sequences in our genome has fueled speculation that over evolutionary time L1 insertions may structurally modify endogenous genes and regulate gene expression. Here we provide a review of L1 replication and its potential functional consequences.
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Cites
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Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
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Self-citationHuman L1 element target‐primed reverse transcription in vitro
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Self-citationTranscriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes
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Self-citationMobile elements and mammalian genome evolution
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“However, protein-coding sequences are a small target (only 1% of the genome((3))) and thus most new L1 integrations are in introns or intergenic regions.((7)) The consequences of these L1 insertions on gene function have not been thoroughly studied.”
BackgroundSelf-citationTransposition of hAT elements links transposable elements and V(D)J recombination
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Cited by
Volff, J. (2006) · BioEssays · doi:10.1002/bies.20452 · Cited by 419
Alu elements as regulators of gene expression
Häsler, J., & Strub, K. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl706 · Cited by 299
The Repetitive DNA Content of Eukaryotic Genomes
López-Flores, I., & Garrido-Ramos, M. A. (2012) · Genome Dynamics · doi:10.1159/000337118 · Cited by 259
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
Wright, R. O., Schwartz, J., Wright, R. J., Bollati, V., Tarantini, L., Park, S. K., Hu, H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901429 · Cited by 235
Molecular and cellular basis of rheumatoid joint destruction
Karouzakis, E., Neidhart, M., Gay, R. E., & Gay, S. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.04.011 · Cited by 167
Metadata
- Authors
- Han, J. S., & Boeke, J. D.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2005
- Volume
- 27
- Issue
- 8
- Pages
- 775-784
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2054236386
- Cited by
- 205
- References
- 12
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
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