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Cited by 441

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

Kerbel, Robert S.·1991·BioEssays
DOI 10.1002/bies.950130106
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Abstract

Cancers have a formidable capacity to develop resistance to a large and diverse array of chemical, biologic, and physical anti‐neoplastic agents. This can be largely traced to the instability of the tumor cell genome, and the resultant ability of tumor cell populations to generate phenotypic variants rapidly. It is therefore argued that anti‐cancer strategies should be directed at eliminating those genetically stable normal diploid cells that are required for the progressive growth of tumors. Micro‐vascular endothelial cells comprising the tumor vasculature represent such a normal cell target. Moreover, specificity for tumor associated vasculature by anti‐cancer agents may be achieved by virtue of the fact that many of the endothelial cells that comprise these blood vessels are in an immature, cycling, and ‘activated’ state, in contrast to the endothelial cells associated with normal tissue and organ blood vessels.

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Crossref · 10.1002/bies.950130106

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Metadata

Authors
Kerbel, R. S.
Venue
BioEssays
Publisher
Wiley
Published
1991-01
Volume
13
Issue
1
Pages
31-36
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.950130106
OpenAlex
W2155056678
Cited by
441
References
47
FWCI
0.57
Type
journal article
Language
en
Open access
closed

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